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Etude morphologique et physiologique du foie adipeux des diabetiques

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Riassunto

Gli AA. studiano, con l'aiuto del microscopio ottico ed elettronico, la seatosi epatica del diabetico. Si insiste sulle modificazioni di struttura della cellula epatica già sovraccaricata di glicogeno, che caratterizzano in qualche modo il diabete mellito. Commentando le modalità fisiopatologiche del sovraccarico grasso del fegato diabetico, gli AA. attribuiscono il ruolo principale se non esclusivo al meccanismo di mobilizzazione dei grassi periferici verso il fegato.

Resume

Les AA. étudient, à l'aide du microscope optique et électronique, le foie adipeux du diabétique. On insiste sur les modifications de structure de la cellule hépatique déjà surchargée en glycogène, qui caractérise en quelque sorte le diabète sucré. En commentant les modalités physiopathologiques de la surcharge graisseuse du foie diabétique, les AA. accordent le rôle principal sinon exclusif au mécanisme par mobilisation des graisses périphériques vers le foie.

Resumen

Los AA. estudian, sirviéndose del microscopio óptico y del electrónico, la degeneración grasosa del hígado en el paciente diabético. Se subrayan las modificaciones de estructura de la célula hepática, que está sobrecargada de glucógeno, lo cual es característico de la diábetes sacarina. Comentando las modalidades fisiopatológicas de la sobrecarga adiposa del hígado diabético, los AA. confieren un papel principal — o mejor dicho exclusivo — al mecanismo de movilización de las grasas periféricas hacia el hígado.

Zusammenfassung

Die AA. untersuchen mittels der optischen und der Elektronenmikroskopie die Lebersteatose des Diabetikers. Es werden insbesondere die strukturellen Veraenderungen der bereits durch Glykogen ueberlasteten Leberzelle hervorgehoben, die in irgendeiner Weise den Diabetes mellitus kennzeichnen. Bei der Besprechung der patho-physiologischen Modalitaeten der Fettmehrbelastung der diabetischen Leber schreiben die AA. die Haupt- wenn nicht die ausschliessliche Rolle dem Mobilisierungsmechanismus der peripheren Fette in Richtung Leber zu.

Summary

The AA. studied, with the aid of light and electron microscopy, the fatty liver in diabetic patients. Emphasis is placed on the structural changes in the liver cell, already loaded with glycogen, which in some degree characterizes diabetes mellitus. The AA. discuss the physiopathological modalities of the fat deposition in diabetic liver and ascribe the main if not the exclusive role to the mechanism of mobilization of peripheral fats directed toward the liver.

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Authors and Affiliations

  1. Clinique des Maladies de la Nutrition et Diététique, Hôpital Cantacuzino, Bucarest, Roumanie

    Ion Pavel, Herman Bonaparte, Dan Sdrobici & Alex Petrovici

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  1. Ion Pavel
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  2. Herman Bonaparte
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  3. Dan Sdrobici
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  4. Alex Petrovici
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Pavel, I., Bonaparte, H., Sdrobici, D. et al. Etude morphologique et physiologique du foie adipeux des diabetiques. Acta diabet. lat 5, 16–30 (1968). https://doi.org/10.1007/BF01548363

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