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Estradiol and testosterone levels in patients undergoing partial hepatectomy

A possible signal for hepatic regeneration?

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Abstract

In five adult male patients undergoing a 40–60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively. Compared to hormone levels found prior to surgery, following major hepatic resection, estradiol levels increase at 24 and 48 hr, while testosterone levels decline, being significantly reduced at 96 and 144 hr. These data demonstrate that adult males who undergo a 40–60% partial hepatectomy experience alterations in their sex hormone levels similar to those observed in male rats following a 70% hepatectomy. These changes in sex hormone levels have been associated in animals with an alteration of the sex hormone receptor status of the liver that is thought to participate in the initiation of the regenerative response. These studies suggest, but do not prove, that in man, as in the case of the rat, sex hormones may participate in the initiation of or at least modulate in part the regenerative response that occurs following a major hepatic resection.

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References

  1. Bucher NLR: Regeneration of mammalian liver. Int Rev Cytol 15:245–300, 1963

    PubMed  Google Scholar 

  2. Bucher NLR, Swaffield MM: Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon. Proc Natl Acad Sci USA 72(3):1157–1160, 1975

    PubMed  Google Scholar 

  3. Caruana JA, Gage AA: Increased uptake of insulin and glucagon by the liver as a signal for regeneration. Surg Gynecol Obstet 150:390–394, 1980

    PubMed  Google Scholar 

  4. Leffert HL, Koch KS, Moran T, Rubalcava R: Hormonal control of rat liver regeneration. Gastroenterology 76:1470–1482, 1979

    PubMed  Google Scholar 

  5. Richman RA, Claus TH, Pilkis SJ, Friedman DL: Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes. Proc Natl Acad Sci USA 73:3589–3593, 1976

    PubMed  Google Scholar 

  6. Fisher B, Fisher ER, Saffer E: Investigations concerning the role of humoral factor in liver regeneration. Cancer Res 23:914–920, 1963

    PubMed  Google Scholar 

  7. Francavilla A, Porter KA, Benichou J: Liver regeneration in dogs: Morphologic and chemical changes. J Surg Res 25:409–419, 1978

    PubMed  Google Scholar 

  8. Francavilla A, DiLeo A, Eagon PK, Wu SQ, Ove P, Van Thiel DH, Starzl TE: Regenerating rat liver: Correlations between estrogen receptor localization and deoxyribonucleic acid synthesis. Gastroenterology 86:552–557, 1984

    Google Scholar 

  9. Francavilla A, Eagon P, DiLeo, Polimeno L, Panella C, Aquilino AM, Ingrosso M, Van Thiel DH, Starzl TE: Sex hormone-related functions in regenerating male rat liver. Gastroenterology 91:1263–1270, 1986

    PubMed  Google Scholar 

  10. Marshall DH, Crilly R, Nordin BEC: The relationship between plasma androstenedione and oestrone levels in untreated and corticosteroid-treated post-menopausal women. Clin Endocrinol 9:407–412, 1978

    Google Scholar 

  11. Porter LE, Elm MS, Van Thiel DH, Dugas MC, Eagon PK: Characterization and quantitation of human hepatic estrogen receptor. Gastroenterology 84:704–712, 1983

    PubMed  Google Scholar 

  12. Aten RF, Dickson RB, Eisenfeld AJ: Estrogen receptor in adult male rat liver. Endocrinology 131:1629–1635, 1978

    Google Scholar 

  13. Eagon PK, Porter LE, Francavilla A, Di Leo A, Van Thiel DH: Estrogen and androgen receptors in liver: Their role in liver disease and regeneration. Semin Liver Dis 5:59–69, 1985

    PubMed  Google Scholar 

  14. Francavilla A, Eagon PK, DiLeo A, Van Thiel DH, Panella C, Polimeno L, Amoruso A, Ingrosso M, Aquilino AM, Starzl TE: Circardian rhythm of hepatic cytosolic and nuclear estrogen and androgen receptors. Gastroenterology 91:182–188, 1986

    PubMed  Google Scholar 

  15. Duffy MJ, Duffy GJ: Estradiol receptors in human liver. J Steroid Biochem 9:233–235, 1978

    PubMed  Google Scholar 

  16. Powell-Jones W, Thompson C, Nayfeh SN, Lucier GW: Sex differences in estrogen binding by cytosolic and nuclear components of rat liver. J Steroid Biochem 13:219–229, 1980

    PubMed  Google Scholar 

  17. Bannister P, Sheridan P, Losowsky MS: Identification and characterization of the human hepatic androgen receptor. Clin Endocrinol 23:294–502, 1985

    Google Scholar 

  18. Turocy IF, Chiang AN, Seeley DH, Eagon PK: Effect of H-2 antagonists on androgen imprinting of male hepatic functions. Endocrinology 117:1953–1961, 1985

    PubMed  Google Scholar 

  19. Eagon PK, Fisher SE, Imhoff AF, Porter LE, Stewart RR, Van Thiel DH, Lester DH: Estrogen binding proteins of male rat livers: Influences of hormonal changes. Arch Biochem Biophys 201:486–499, 1980

    PubMed  Google Scholar 

  20. Corvol PL, Chrambach A, Rodbard D, Bardin CW: Physical properties and binding capacity of testosterone-binding globulin in human plasma determined by polyacrylamide electrophoresis. J Biol Chem 246:3435–3443, 1971

    PubMed  Google Scholar 

  21. Laragh JH, Baer L, Brunner HR, Bumler F, Sealey BS, Darragot Vaughan E: Renin angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am J Med 52:633–652, 1972

    PubMed  Google Scholar 

  22. Menard J, Corvol P, Foliot A, Raynaud JP: Effects of estrogens on renin substrate and uterine weights in rats. Endocrinology 93:747–751, 1973

    PubMed  Google Scholar 

  23. Song CS, Rifkind AB, Gillette PN, Kappas A: Hormones and the liver: The effect of estrogens, progestines and pregnancy on hepatic function. Am J Obstet Gynecol 105:813–847, 1969

    PubMed  Google Scholar 

  24. Saint Aubert B, Vic P, Brissac C: Regeneration hepatique chez le rat apres hepatectomie subtotale (90%) traite a la testosterone. CR Acad Sci Paris 291:653–655, 1980

    Google Scholar 

  25. Bengmark S, Olson R: The effect of testosterone on liver healing after partial hepatectomy. Acta Chir Scand 127:93–100, 1964

    PubMed  Google Scholar 

  26. Vic P, Saint-Aubert B, Astre C, Bories P, Bonardet A, Descomps B, Humeau C, Joyeaux H: Complete liver regeneration of one-state 90% hepatectomized rats treated with testosterone. Hepatology 2:247–248, 1982

    PubMed  Google Scholar 

  27. Bengmark S, Olson R, Rehnstrom B: Effect of testosterone in partially hepatectomized female rats. Scand J Gastroenterol 2:90–94, 1967

    Google Scholar 

  28. Simck J, Husakova A, Erbenova Z, Kanta J: Role of adrenals in changes of liver triglycérides content after partial hepatectomy in rats of different ages. Physiol Bohemoslov 17:563–567, 1968

    PubMed  Google Scholar 

  29. Seidman I, Teebor GW, Becker FF: Hormonal and substrate induction of tryptophan pyrrolase in regenerating rat liver. Cancer Res 27:1620–1625, 1967

    PubMed  Google Scholar 

  30. Raab KH, Webb TH: Inhibition of DNA synthesis in regenerating rat liver by hydrocortisone. Experentia 25:1240–1242, 1969

    Google Scholar 

  31. Sakuma K, Terayama H: Effects of adrenal hormones upon DNA synthesis in regenerating rat liver and tumors. J Biochem 61:504–511, 1967

    PubMed  Google Scholar 

  32. Davis JC, Hyde TA: Effect of corticosteroids and altered adrenal function on liver regeneration following chemical necrosis and partial hepatectomy. Cancer Res 26:217–220, 1966

    PubMed  Google Scholar 

  33. Majumdar C, Tsukada K, Lieberman I: Liver protein synthesis after partial hepatectomy and acute stress. J Biol Chem 242:700–704, 1967

    PubMed  Google Scholar 

  34. Simck J, Erbenova Z, Deml F, Dvorackova I: Liver regeneration after partial hepatectomy in rats exposed before operation to stress stimulus. Experientia 24:1166–1167, 1968

    PubMed  Google Scholar 

  35. Moolten FL, Oakman NJ, Bucker NLR: Accelerated response of hepatic DNA synthesis to partial hepatectomy in rats pre-treated with growth hormone or surgical stress. Cancer Res 30:2353–2357, 1970

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Gastroenterology and Surgery, University of Bari, Bari, Italy

    A. Francavilla MD, J. S. Gavaler PhD, L. Makowka MD, PhD, M. Barone MD, V. Mazzaferro MD, G. Ambrosino MD, S. Iwatsuki MD, F. W. Guglielmi MD, A. Dileo MD, A. Balestrazzi MD, D. H. Van Thiel MD & T. E. Starzl MD, PhD

  2. Departments of Surgery and Gastroenterology, University of Pittsburgh Health Center, University of Pittsburgh, USA

    A. Francavilla MD, J. S. Gavaler PhD, L. Makowka MD, PhD, M. Barone MD, V. Mazzaferro MD, G. Ambrosino MD, S. Iwatsuki MD, F. W. Guglielmi MD, A. Dileo MD, A. Balestrazzi MD, D. H. Van Thiel MD & T. E. Starzl MD, PhD

  3. Veterans Administration Medical Center, Pittsburgh, Pennsylvania

    A. Francavilla MD, J. S. Gavaler PhD, L. Makowka MD, PhD, M. Barone MD, V. Mazzaferro MD, G. Ambrosino MD, S. Iwatsuki MD, F. W. Guglielmi MD, A. Dileo MD, A. Balestrazzi MD, D. H. Van Thiel MD & T. E. Starzl MD, PhD

Authors
  1. A. Francavilla MD
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  2. J. S. Gavaler PhD
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  3. L. Makowka MD, PhD
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  4. M. Barone MD
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  5. V. Mazzaferro MD
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  6. G. Ambrosino MD
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  7. S. Iwatsuki MD
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  8. F. W. Guglielmi MD
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  9. A. Dileo MD
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  10. A. Balestrazzi MD
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  11. D. H. Van Thiel MD
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  12. T. E. Starzl MD, PhD
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Additional information

Supported by research grants from the Veterans Administration; project grant DK29961 from the National Institutes of Health, Bethesda, Maryland; by grant 87/0129144 from the Consiglio Nazionale dell Ricerche, Italy; and by grant AA04425 from NIH.

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Francavilla, A., Gavaler, J.S., Makowka, L. et al. Estradiol and testosterone levels in patients undergoing partial hepatectomy. Digest Dis Sci 34, 818–822 (1989). https://doi.org/10.1007/BF01540264

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  • DOI: https://doi.org/10.1007/BF01540264

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