Abstract
cDNAs encoding human proteins C and S have been used to screen a panel of mouse-human somatic cell hybrids to determine the chromosomal location of their respective genes. The gene for human protein C is located on chromosome 2, whereas that for protein S is located on chromosome 3. Analysis of human genomic DNA restriction endonuclease fragmentation patterns suggests that the human protein S gene is greater than 40 kb in size and contains a minimum of 11 introns.
Literature cited
Stenflo, J. (1984).Semin. Thromb. Hemostasis 10:109–121.
Clouse, L.H., and Comp, P.C. (1986).N. Engl. J. Med. 314:1298–1304.
Esmon, C.T., and Owen, W.G. (1981).Proc. Natl. Acad. Sci. U.S.A. 78:2249–2252.
Esmon, N.L., Woen, W.G., and Esmon, C.T. (1982).J. Biol. Chem. 257:859–864.
Kisiel, W., Canfield, W.M., Ericsson, L.H., and Davie, E.W. (1977).Biochemistry 16:5824–5831.
Vehar, G.A., and Davie, E.W. (1980).Biochemistry 19:401–410.
Walker, F.J. (1984).Semin. Thromb. Hemostasis 10:131–138.
Walker, F.J. (1981).J. Biol. Chem. 256:11128–11131.
Harris, K.W., and Esmon, C.T. (1985).J. Biol. Chem. 260:2007–2010.
Stern, D.M., Nawroth, P., Harris, K.W., and Esmon, C.T. (1986).J. Biol. Chem. 261:713–718.
Gardiner, J.E., and Griffin, J.H. (1983). InProgress in Hematology, Vol XIII, (ed.) Brown, E.B. (Grune and Stratton, city), pp. 265–278.
Seligson, U., Beyer, A., Abend, M.,et al. (1984).N. Engl. J. Med. 310:559–562.
Brockmans, A.W. (1985).Haemostasis 15:233–240.
Schwarz, H.P., Heeb, M.J., Wencel-Drake, J.D., and Griffin, J.H. (1985).Blood 66:1452–1455.
Bertina, R.M. (1985).Haemostasis 15:241–246.
Gladson, C.L., Griffin, J.H., Hack, V., Beck, K.H., and Schaner, I. (1985).Blood 66:350a.
Beckman, R.J., Schmidt, R.J., Santerre, R.F., Plutzky, J., Crabtree, G.R., and Long, G.L. (1985).Nucleic Acids Res. 13:5233–5247.
Hoskins, J.A., Norman, D.K., Beckmann, R.J., and Long, G.L. (1987).Proc. Natl. Acad. Sci. U.S.A. 84:349–353.
Suttie, J.W. (1985).Annu. Rev. Biochem. 54:459–477.
Fernlung, P., and Stenflo, J. (1983).J. Biol. Chem. 258:12509–12512.
Stenflo, J., Lundwall, A., and Dahlback, B. (1987).Proc. Natl. Acad. Sci. U.S.A. 84:368–372.
Davidson, R.L., and Gerald, P.S. (1976).Somat. Cell Genet. 2:165–176.
Littlefield, J.W. (1964).Science 145:709–710.
Naylor, S.L., Sakaguchi, A.Y., Szoka, P., Hendy, G.N., Kronenberg, H.M., Rich, A., and Shows, T.B. (1983).Somat. Cell Genet. 9:609–616.
Shows, T.B., Sakaguchi, A.Y., and Naylor, S.L. (1982).Adv. Hum. Genet. 12:341–452.
Southern, E.M. (1975).J. Mol. Biol. 98:503–517.
Naylor, S.L., Sakaguchi, A.Y., Shows, T.B., Law, M.L., Goeddel, D.V., and Gray, P.W. (1983).J. Exp. Med. 157:1020–1027.
Young, R.A., and Davis, R.W. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:1194–1198.
Rigby, P.W.J., Dieckman, M., Rhodes, C., and Berg, P. (1977).J. Mol. Biol. 113:237–251.
Rocchi, M., Roncuzzi, L., Santamaria, R., Sbarra, D., Mochi, M., Archrdiacono, N., Covone, A., Corese, R., and Romes, G. (1985).Cytogenet. Cell Genet. 40:734.
Foster, D.C., Yoshitake, S., and Davie, E.W. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:5653–5656.
Plutzky, J., Hoskins, J.A., Long, G.L., and Crabtree, G.R. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:546–550.
Bernardi, G., and Bernardi, G. (1986).Cold Spring Harbor Symp. Quant. Biol. 51:479–487.
O'Hara, P.J., Grant, F.J., Haldeman, B.A., et al. (1987).Proc. Natl. Acad. Sci. U.S.A. 84:(in press).
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Long, G.L., Marshall, A., Gardner, J.C. et al. Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively. Somat Cell Mol Genet 14, 93–98 (1988). https://doi.org/10.1007/BF01535052
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DOI: https://doi.org/10.1007/BF01535052