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Studien an einem Burkitt-Lymphom

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Zusammenfassung

Wir berichten über den ersten uns bekannten Fall eines serologisch gesicherten Burkitt-Lymphoms in Deutschland. Die Histologie ergab das typische Bild eines „Sternenhimmels“. Das Serum des Patienten enthielt präcipitierende Antikörper gegen das aus Burkitt-Gewebe-Kulturzellen gewonnene Antigen. Der Antikörpertiter im indirekten Fluorescenztest war 1:640. Stoffwechseluntersuchung der Zellen ergab eine signifikante Glutaminmangelempfindlichkeit ohne gleichzeitige Asparaginabhängigkeit. Die klinischen Befunde, das typische histologische Bild und das initial eindrucksvolle Ansprechen auf die Chemotherapie zusammen mit dem hohen Antikörpertiter gegen das Epstein-Barr-Virus lassen die Diagnose Burkitt-Lymphom gesichert erscheinen. Epidemiologie, Klinik, Histologie und Immunologie werden im Lichte der heute bekannten Tatsachen über das Burkitt-Lymphom diskutiert.

Summary

We here report the first case of Burkitt-Lymphoma in Germany with positive serology. The serum of the patient showed precipitating antibodies against antigens derived from Burkitt cells, the antibody titer in the indirect fluorescence test with Burkitt tissue culture cells was 1:640. The cells showed a marked inhibition of protein synthesis in the absence of glutamine in the tissue culture medium. There was no inhibition in the absence of asparagine. The clinical features, the typical histology, the initially good response to chemotherapy, and the high anti-EBV antibody titer were consistent with the diagnosis Burkitt-Lymphoma. These findings are discussed, the current literature is reviewed.

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Authors and Affiliations

  1. Innere Klinik und Poliklinik (Tumorforsehung) Kinderklinik der Ruhruniversität Bochum, Klinikum Essen, Germany

    W. M. Gallmeier, F. W. Göbel, W. Hartung & C. G. Schmidt

  2. Pathologisches Institut der Universität Münster, Germany

    W. M. Gallmeier, F. W. Göbel, W. Hartung & C. G. Schmidt

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  1. W. M. Gallmeier
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  2. F. W. Göbel
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  3. W. Hartung
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  4. C. G. Schmidt
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Gallmeier, W.M., Göbel, F.W., Hartung, W. et al. Studien an einem Burkitt-Lymphom. Klin Wochenschr 48, 537–542 (1970). https://doi.org/10.1007/BF01488568

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