Abstract
Plasma growth hormone-binding protein (GH-BP) activity was evaluated in two groups of prepubertal children with chronic renal failure (CRF) who had been treated with recombinant human GH (rhGH). Group 1 consisted of eight children (mean chronological age 10.8 years) with advanced renal failure; group 2 consisted of nine children (mean chronological age 6 years) presenting with end-stage renal disease, who were on dialysis. Before treatment the specific binding of (125I)hGH to highaffinity GH-BP was low in the two groups (group 1, 17.3±1.6% of radioactivity; group 2, 14.2±1.4%) compared with the mean value obtained in normal prepubertal children (24.8±1.7%). No significant changes in GH-BP activity were found during the 1st year of GH therapy, although growth velocity and plasma levels of insulin-like growth factor-I increased significantly in both groups. The low GH-binding activity found in children with CRF supports the state of GH resistance. The reason for the absence of a GH-BP response to GH therapy has to be clarified.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
El-Bishi MM, Counahan R, Bloom SS, Chantler C (1978) Hormonal and metabolic responses to intravenous glucose in children on regular hemodialysis. Am J Clin Nutr 31: 1865–1869
Ramirez G, O'Neill WN, Bloomer HA, Jubiz W (1978) Abnormalities in the regulation of growth hormone in chronic renal failure. Arch Intern Med 138: 267–271
Goldberg A, Trivedi B, Delmez J, Harter H, Daughaday W (1982) Uremia reduces insulin-like growth factor I, increases insulin-like growth factor II, and modifies their serum protein binding. J Clin Endocrinol Metab 55: 1040–1045
Powell D, Rosenfeld R, Baker B, Liu F, Hintz R (1986) Serum somatomedin levels in adults with chronic renal failure: the importance of measuring insulin-like growth factor I (IGF-I) and IGF-II in acid-chromatographed uremic serum. J Clin Endocrinol Metab 63: 1186–1192
Mehls O, Ritz E, Hunziker EB, Eggli P, Heinrich U, Zapf J (1988) Improvement of growth and food utilization by human recombinant growth hormone in uraemia. Kidney Int 33: 45–52
Koch V, Lippe BM, Nelson PA, Boechat MI, Sherman BM, Fine RN (1989) Accelerated growth after recombinant human growth hormone treatment of children with chronic renal failure. J Pediatr 115: 365–371
Tönshoff B, Mehls O, Heinrich U, Bloom WU, Ranke MB, Schauer A (1990) Growth-stimulating effects of recombinant human growth hormone in children with end-stage renal disease. J Pediatr 116: 561–566
Baumann G, Stolar MW, Amburn K, Barsano CP, Devries BC (1986) A specific growth hormone-binding protein in human plasma: initial characterization. J Clin Endocrinol Metab 62: 134–141
Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI (1987) Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 330: 537–543
Tar A, Hocquette JF, Souberbielle JC, Clot JP, Brauner R, Postel-Vinay MC (1990) Evaluation of the growth hormone-binding proteins in human plasma using HPLC-gel filtration. J Clin Endocrinol Metab 71: 1202–1207
Postel-Vinay MC, Tar A, Hocquette JF, Brauner R, Rappaport R (1990) Growth hormone increases and testosterone decreases the GH-binding activity in human plasma (abstract). Abstracts of the 72nd Annual Meeting of the Endocrine Society, June 1990, Atlanta, p 248
Finidori J, Postel-Vinay MC, Kleinknecht C (1980) Lactogenic and somatotropic binding sites in liver membranes of rats with renal insufficiency. Endocrinology 106: 1960–1965
Baxter RC, Zalstman Z, Turtle JR (1984) Rat growth hormone but not prolactin induces both GH and PRL receptors in female rat liver. Endocrinology 114: 1893–1901
Hattori N, Kato Y, Murakami Y, Hashida S, Mohri Z, Imura H (1988) Urinary growth hormone levels measured by ultrasensitive enzyme immunoassay in patients with renal insufficiency. J Clin Endocrinol Metab 66: 727–732
Hattori N, Shimatsu A, Kato Y, Imura H (1990) Growth hormone and growth hormone binding protein in human urine. Kidney Int 37: 951–954
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Postel-Vinay, M.C., Tar, A., Crosnier, H. et al. Plasma growth hormone-binding activity is low in uraemic children. Pediatr Nephrol 5, 545–547 (1991). https://doi.org/10.1007/BF01453698
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01453698