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Gangliosides in meningiomas: Correlation of Glac 2 to intermediary filament

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Summary

Human meninges and 29 meningiomas were analyzed as to their glycosphingolipid composition. In the neutral fraction GSL, a mostly even distribution of mono-, di-, tri-and tetrahexoside was demonstrated. In the group of the gangliosides, Glac 1 in one broad band in chromatogramms occurred in almost all meningiomas; Glac 2 was present in 84% of tumours. Members of the Gtri-family were only found in a small minority of tumours while various Gtet-gangliosides were detectable in nearly half of them. No constant pattern or patterns emerged and no correlation to either morphological subtype or malignancy grade could be established. Immunohistochemistry revealed focal presence of Glac 2 in a pattern similar to that of vimentin expression. Semiquantitative evaluation showed good correlation between both parameters.

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Abbreviations

WHO:

World Health Organization

GSL:

Glycosphingolipids

aGSL:

acidic GSL

nGSL:

neutral GSL

For Gangliosides:

G stands for ganglioside, the index denominates the sugar complex (lac=lactose, tri=triaose, tet=tetraose) and the following cipher denotes the number of sialic acids. The Svennerholm notation (1963) is sometimes given in brackets. Glac1=GM3, Glac2=GD3, Gtri1=GM2, Gtri2=GD2, Gtet1=GM1, Gtet2a=GD1 a and so on.

CMH:

Ceramid monohexoside

CDH:

Ceramid dihexoside

CTH:

Ceramid trihexoside

CTetH:

Ceramid tetrahexoside

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Authors and Affiliations

  1. Physiologisch-chemisches Institut, Philipps Universität Marburg, Federal Republic of Germany

    G. Pausch, R. Jennemann & H. Wiegandt

  2. Abteilung Neuropathologie, Zentrum Pathologie, Philipps Universität Marburg, Federal Republic of Germany

    H. D. Mennel

  3. Abteilung für Neurochirurgie, Zentrum für operative Medizin, Philipps Universität Marburg, Federal Republic of Germany

    B. L. Bauer & A. F. Rodden

Authors
  1. G. Pausch
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  2. R. Jennemann
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  3. H. D. Mennel
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  4. B. L. Bauer
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  5. A. F. Rodden
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  6. H. Wiegandt
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Pausch, G., Jennemann, R., Mennel, H.D. et al. Gangliosides in meningiomas: Correlation of Glac 2 to intermediary filament. Acta neurochir 117, 166–171 (1992). https://doi.org/10.1007/BF01400615

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