Abstract
The effect of a tablet containing the antiflatulent, simethicone, on intestinal hydrogen (H2) elimination in breath was studied. In three trials, normal subjects (age 12–52 years) received, on subsequent days, lactulose or lactulose with two tablets of either simethicone or placebo in randomized order. Breath samples were collected over 210 min and analyzed by gas chromatography for H2. The time course of H2 expiration above baseline levels was calculated and compared for the three tests. No significant differences in transit time were found. Cumulative H2 expiration was significantly lower after simethicone compared to placebo. H2 production from stool incubated with simethicone or placebo indicated that the drug had no effect in reducing the fermentative production of H2 in vitro. Interestingly, the vehicle present in the tablets could be fermented by intestinal bacteria. Simethicone reduced the amount of H2 eliminated in breath, but this effect was offset partially by H2 production from the fermentation of unabsorbable substances used in the formulation of the tablets.
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References
Waye JD, Pitman E, Weiss A, Krueger K: The bubble problem in endoscopy. Gastrointest Endosc 14:34–35, 1975
Weiss J: Etiology and management of intestinal gas. Curr Ther Res 16(9):909–920, 1974
Danhof IE, Stavola JJ: Accelerated transit of intestinal gas with simethicone. Obstet Gynecol 44(1):148–154, 1974
Calloway DH, Colasoto DJ, Mathews RD: Gases produced by human intestinal microflora. Nature 212:1238–1239, 1966
Levitt MD: Production and excretion of hydrogen gas in man. N Engl J Med 281:122, 1969
Perman JA, Modler S: Glycoproteins as substrates for production of hydrogen and methane by colonic bacterial flora. Gastroenterology 83:388–393, 1982
Bond JM Jr, Levitt MD: Use of pulmonary hydrogen measurements to quantitate carbohydrate absorption. Study of partially gastrectomized patients. J Clin Invest 51:1219–1225, 1972
Niu HC, Schoeller DA, Klein PD: Improved gas chromatographic quantitation of breath hydrogen by normalization to respiratory carbon dioxide. J Lab Clin Med 94:755–763, 1979
Hall RG Jr, Thompson H, Strother A: Effects of orally administered activated charcoal on intestinal gas. Am J Gastroenterol 75:192–196, 1981
Perman JA, Modler S, Olson A: Role of pH in production of hydrogen from carbohydrates by colonic bacterial flora. J Clin Invest 67:643–650, 1981
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Lifschitz, C.H., Irving, C.S. & Smith, E.O. Effect of a simethicone-containing tablet on colonic gas elimination in breath. Digest Dis Sci 30, 426–430 (1985). https://doi.org/10.1007/BF01318174
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DOI: https://doi.org/10.1007/BF01318174