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Differences in the mechanism of induction of interferon-alpha by Herpes simplex virus and Herpes simplex virus-infected cells

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Summary

The cellular source of IFN alpha after induction with Herpes simplex virus type-1 (HSV) and HSV-infected fibroblasts was investigated by using human peripheral blood mononuclear cell (PBMC) populations, purified according to conventional procedures, and which included T- and B-lymphocytes as well as monocytes. It appears that the cells responding to HSV virions are monocytes, whereas the PBMC population induced by HSV-infected cells is represented by B-lymphocytes. Furthermore, by using monoclonal antibody (MoAb) to HLA class I and class II products, it appears that different membrane structures are involved in the induction of IFN by HSV virions, as opposed to HSV-infected cells. In fact, most anti-HLA class II MoAbs inhibit IFN induction by HSV-infected cells, and not IFN induction by HSV virions.

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Authors and Affiliations

  1. Institute of Virology, University of Rome, Rome, Italy

    M. R. Capobianchi, P. Di Marco & F. Dianzani

  2. Laboratory of Cell Biology, Department of Genetics, Biology, and Medical Chemistry, University of Turin, Turin, Italy

    F. Malavasi

Authors
  1. M. R. Capobianchi
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  2. F. Malavasi
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  3. P. Di Marco
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  4. F. Dianzani
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Capobianchi, M.R., Malavasi, F., Di Marco, P. et al. Differences in the mechanism of induction of interferon-alpha by Herpes simplex virus and Herpes simplex virus-infected cells. Archives of Virology 103, 219–229 (1988). https://doi.org/10.1007/BF01311094

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  • DOI: https://doi.org/10.1007/BF01311094

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