Summary
We had previously showed that following intracerebral inoculation of newborn mice, the 910 N and M strains of bovine parainfluenza 3 virus induce a non-lethal hydrocephalus and a lethal diesease with marked thymic and splenic atrophy, respectively. Moreover, only the M virus was lethal for 2-week-old mice.
In the present study, we demonstrate that the M virus multiplies and spreads in the mouse brain invading the thalamus, hypothalamus and brain stem beyond the ependyma whereas the 910 N virus causes only slight ependymitis. This growth and spread of M virus was blocked by passive immunization 3 days after infection. Mouse embryo brain cell cultures were infected with M and 910 N viruses, about 50 per cent became antigenpositive for M whereas only a small proportion of cells were positive for the 910 N virus. However, the latter did produce higher yields of infectious virus than M.
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Shibuta, H., Kanda, T., Nozawa, A. et al. Experimental parainfluenza virus infection in mice: Growth and spread of a highly pathogenic variant of parainfluenza 3 virus in the mouse brain. Archives of Virology 83, 43–52 (1985). https://doi.org/10.1007/BF01310963
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DOI: https://doi.org/10.1007/BF01310963