Abstract
Previous studies in man and preliminary experiments in the pig suggested an exponential healing rate for both gastric ulcers and induced mucosal defects. This was further investigated in six pigs with histamine-induced hyperacidity and in six controls. Healing of simple surgical defects measuring ∼1.5 cm was endoscopically monitored at 2- to 3-day intervals through a Thomas cannula. In the control animals the healing rate was not strictly exponential but conformed to an organic decay curve with maximum healing phase around the fifth day and a slow initial and late healing velocity. In the six histamine-treated animals the healing rate was significantly delayed (P<0.02) in the first four days but thereafter resembled that of the control animals. This suggests that acid secretion may be a determinant factor, especially within the early healing phase.
Similar content being viewed by others
References
Scheurer U, Witzel L, Halter F, Keller HM, Huber R, Galeazzi R: Gastric and duodenal ulcer healing under placebo treatment. Gastroenterology 72:838–841, 1977
Hay LJ, Varco RL, Code ChF: The experimental production of gastric and duodenal ulcers in laboratory animals by intramuscular injection of histamine in beeswax. Surg Gynecol Obstet 75:170–182, 1942
Halter F, Barbezat GO, van Hoorn-Hickman R, Bank S: Eine einfache Methode zur wiederholten Gastroskopie des nicht anästhesierten Schweins. Z Gastroenterol 15:617–618, 1977
Dixon WJ (ed). Biomedical Computer Program, University of California Press, Berkeley 1977
Peacock EE: Wound healing and wound care.In Principles of Surgery, SJ Schwartz (ed). McGraw-Hill, New York, 1969, pp 226–248
Flood ChA, Howes EL: Experimental study of the effect of histamine on the healing of gastric defect-artificial gastric ulcer. Surg Gynecol Obstet 58:136–144, 1934
Price PhB: Repair in the normal and hyperacid stomach. Surg Gynecol Obstet 86:59–63, 1948
Sugawa Ch, Lucas ChE, Walt AJ: Effect of histamine and aspirin on healing of standardized gastric ulcers in dogs. Surgery 70:590–594, 1971
Silvis SE, Blackwood WD: Observations on the healing of gastric lesions produced by gastroscopy. Gastroenterology 64:370–374, 1973
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Halter, F., Barbezat, G.O., Van Hoorn-Hickman, R. et al. Healing dynamics of traumatic gastric mucosal defects in the normal and hyperacid stomach. Digest Dis Sci 25, 916–920 (1980). https://doi.org/10.1007/BF01308041
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01308041