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Influence ofin situ neural isolation of jejunoileum on postprandial pancreatobiliary secretion and gastric emptying

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Abstract

Our aims were to examine the influence of neural isolation of the jejunoileum on opstprandial pancreatobiliary secretion. In four dogs, duodenal perfusion and aspiration catheters were implanted, and serosal electrodes were placed along the proximal small bowel. Control studies of gastric emptying output of bile acids and amylase, and plasma concentrations of peptide YY and neurotensin were performed on three occasions following ingestion of a 340-kcal mixed-nutrient liquid meal. The dogs then underwent our model ofin situ jejunoileal neural isolation, and the meal studies were repeated. Neural isolation, when compared to control, did not affect either postprandial conversion of intestinal myoelectric activity to the “fed” pattern, gastric emptying (T1/2,X±se of the liquid meal (74±6 vs 79±7 min;P>0.05), or cumulative amylase output (373±59 vs 305±66 kU;P>0.05). Neural isolation decreased cumulative postprandial bile acid output from 6.6±0.9 mM to 3.4±1.1 mM (P<0.05) and increased postprandial plasma concentrations of peptide YY and neurotensin. Our findings suggest that the jejunoileal denervation that accompanies thein situ neural isolation of the jejunoileum is not associated with changes in postprandial motility patterns, gastric emptying, or pancreatic amylase secretion. Loss of this innervation, however, may decrease postprandial output of bile acids and lead to a compensatory increase in the postprandial release of neurotensin and peptide YY.

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References

  1. Watson AJM, Lear PA: Current status of intestinal transplantation. Gut 30:1771–1782, 1989

    Google Scholar 

  2. Sarr MG, Duenes JA: Autotransplantation of the entire jejunoileum in dogs: Effects on jejunal and ileal absorptive functions. Gastroenterology 96:A441, 1990

    Google Scholar 

  3. Sarr MG, Duenes JA, Tanaka M: A model of jejunoileal in vivo neural isolation of the entire jejunoileum: Transplantation and the effects on intestinal motility. J Surg Res 47:266–272, 1989

    Google Scholar 

  4. Sarr MG, Tanaka M, Duenes JA: Jejunoileal autotransplantation: effects on small intestinal motility. Surg Forum 38:160–162, 1987

    Google Scholar 

  5. Solomon TE: Control of exocrine pancreatic secretion.In Physiology of the Gastrointestinal Tract, 2nd ed. LR Johnson (ed). New York, Raven Press, 1987, pp 1173–1207

    Google Scholar 

  6. Code CF, Marlett JA: The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol (London) 246:289–309, 1975

    Google Scholar 

  7. Tanaka M, Sarr MG: The role of the duodenum in the control of canine gastrointestinal motility. Gastroenterology 94:622–629, 1988

    Google Scholar 

  8. Zinterhoffer L, Wardlaw S, Jatlow P, Seligson D: Nephelometric determination of pancreatic enzymes. I. Amylase. Clin Chim Acta, 43:5–12, 1973

    Google Scholar 

  9. Talalay P: Enzymatic analysis of steroid hormones. Methods Biochem Anal 8:119–143, 1960

    Google Scholar 

  10. Koch TR, Roddy DR, Reilly WA, Carney JA, Go VLW: Distribution and quantitation of peptide YY in normal colon, Crohn's colitis, and ulcerative colitis. Can J Physiol Pharmacol 64(suppl):17–18, 1985

    Google Scholar 

  11. Micevych PE, Yaksh TL, Go VLW: Opiate-mediated inhibition of the release of cholecystokinin and substance P, but not neurotensin from cat hypothalamic slices. Brain Res 250:283–289, 1982

    Google Scholar 

  12. Sarr MG, Duenes JA, Zinsmeister AR: Factors in the control of interdigestive and postprandial myoelectric patterns of canine jejunoileum: Role of extrinsic and intrinsic nerves. J Gastrointest Motil 2:247–257, 1990

    Google Scholar 

  13. Miller LJ, Clain JE, Malagelada J-R, Go VLW: Control of human postprandial pancreatic exocrine secretion: A function of the gastroduodenal region. Dig Dis Sci 24:150–154, 1979

    Google Scholar 

  14. Singer MV, Solomon TE, Wood J, Grossman MI: Latency of pancreatic enzyme response to intraduodenal stimulants. Am J Physiol 238:G23-G29, 1980

    Google Scholar 

  15. Watanabe S, Shiratori K, Takeuchi T, Chey WY, You CH, Chang TM: Release of cholecystokinin and exocrine pancreatic secretion in response to an elemental diet in human subjects. Dig Dis Sci 31:919–924, 1986

    Google Scholar 

  16. Ertan A, Brooks FP, Ostrow JD, Arvan DA, Williams CN, Cerda JJ: Effect of jejunal amino acid perfusion and exogenous cholecystokinin on the exocrine pancreatic and biliary secretions in man. Gastroenterology 61:686–692, 1971

    Google Scholar 

  17. DiMagno EP, Go VLW, and Summerskill WHJ: Intraluminal and postabsorptive effects of amino acids on pancreatic enzyme secretion. J Lab Clin Med 82: 241–248, 1973

    Google Scholar 

  18. Tohno H, Chung JB, Sarr MG, DiMagno EP: Do different mechanisms regulate postprandial pancreatic enzyme secretion by intraileal carbohydrate (CHO), fat, and protein? Gastroenterology 98:A237, 1990 (abstract)

    Google Scholar 

  19. Singer MV, Niebel W, Beglinder C: Pancreatic exocrine secretion in dogs with an autotransplanted entire jejunoileum. Dig Dis Sci 34:987, 1989 (abstract)

    Google Scholar 

  20. Singer MV, Niebel W, Beglinder C: Pancreatic exocrine secretion in dogs with an autotransplanted entire jejunoileum. Gastroenterology 96:A475, 1989 (abstract)

    Google Scholar 

  21. Keane FB, DiMagno EP, Dozois RR, Go VLW: Relationships among canine interdigestive exocrine pancreatic and biliary flow, duodenal motor activity, plasma pancreatic polypeptide, and motilin. Gastroenterology 78:310–316, 1980

    Google Scholar 

  22. Pappas T, Debas, H, Goto Y, Taylor I: Peptide YY inhibits meal-stimulated pancreatic and gastric secretion. Am J Physiol 248:G118-G123 1985

    Google Scholar 

  23. Hosotani R, Inoue K, Kogire M, Tatemoto K, Mutt V, Suzuki T, Rayford PL, Tobe T: Effect of natural peptide YY on pancreatic secretion and cholecystokinin release in conscious dogs. Dig Dis Sci 34:468–473, 1989

    Google Scholar 

  24. Baca I, Feurle GE, Knauf W, Carraway R: Relationships between neurotensin and pancreatic secretion in the dog. Ann NY Acad Sci 400:400–402, 1982

    Google Scholar 

  25. Baca I, Feurle GE, Schwab A, Mittman U, Knauf W, Lehnert T: Effect of neurotensin on exocrine pancreatic secretion in dogs. Digestion 23:174–183, 1982

    Google Scholar 

  26. Liebow C: Nonparallel pancreatic secretion: Its meaning and implications. Pancreas 3:343–351, 1988

    Google Scholar 

  27. Minasi JS, Taylor MS, Nakahara S, Waldhausen JHT, Jones RS, Schirmer BD: Peptide YY: A potent inhibitor of biliary secretion. Surg Forum 40:161–163, 1989

    Google Scholar 

  28. Taylor IL: Distribution and release of peptide YY in dog measured by specific radioimmunoassay. Gastroenterology 88:731–737, 1988

    Google Scholar 

  29. Hakim NS, Walters AM, Dalton RR, Twomey CK, Sarr MG: Canine jejunoileal (auto)transplantation: effect on jejunal absorption of water electrolytes and glucose. Gastroenterology 98:A173, 1990 (abstract)

    Google Scholar 

  30. Allen J, Fitzpatrick M, Yeats J, Darcy K, Adrian T, and Bloom S: Effects on peptide YY and neuropeptide Y on gastric emptying in man. Digestion 30:255–262, 1984

    Google Scholar 

  31. Blackburn AM, Bloom SR, Long RG, Fletcher DR, Christofides ND, Fitzpatrick ML, Baron JH: Effect of neurotensin on gastric function in man. Lancet 1:987–989, 1980

    Google Scholar 

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Author notes

  1. Michael G. Sarr MD

    Present address: Department of Surgery, the Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, 55905, Rochester, Minnesota

  2. Vay Liang W. Go MD

    Present address: Department of Medicine, University of California at Los Angeles, 10833 LeConte Avenue, 90024-1736, Los Angeles, California

Authors and Affiliations

  1. Department of Surgery, the Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, 55905, Rochester, Minnesota

    Nathaniel J. Soper MD, Eugene P. DiMagno MD, Keith A. Kelly MD &  Vay Liang W. Go MD

  2. Digestive Diseases Core Center, Mayo Clinic and Mayo Foundation, 200 First Street S.W., 55905, Rochester, Minnesota

    Nathaniel J. Soper MD,  Michael G. Sarr MD, Eugene P. DiMagno MD, Keith A. Kelly MD &  Vay Liang W. Go MD

Authors
  1. Nathaniel J. Soper MD
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  2. Michael G. Sarr MD
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  3. Eugene P. DiMagno MD
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  4. Keith A. Kelly MD
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  5. Vay Liang W. Go MD
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Additional information

This work was supported by NIH grants DK34988, AM07198, DK39337, and by the U.S. Surgical Corporation.

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Soper, N.J., Sarr, M.G., DiMagno, E.P. et al. Influence ofin situ neural isolation of jejunoileum on postprandial pancreatobiliary secretion and gastric emptying. Digest Dis Sci 36, 880–887 (1991). https://doi.org/10.1007/BF01297135

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  • DOI: https://doi.org/10.1007/BF01297135

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