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Increased platelet serotonin in bipolar depression and hypomania

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Summary

Platelet serotonin (5-HT) was higher at 8 a.m. in untreated bipolar depressives than in controls. This high 5-HT was different from unipolar depressives where 5-HT levels were similar to controls but showed altered diurnal rhythmicity. Further differences between unipolar and bipolar patients were found. 5-HT levels and 5-HT uptake into platelets were not correlated in bipolar depressives as found in both unipolar depressives and controls; and 5-HT levels and platelet monoamineoxidase activity tended to be negatively correlated in bipolar but not in unipolar depressives and controls. A longitudinal study of a bipolar II patient throughout three hospitalizations for depression followed by the switch into hypomania, indicated that 5-HT was state independent, remaining constantly high in all clinical conditions and upon remission, reduced only during and after treatment with clomipramine, a 5-HT uptake inhibitor. These observations add further support to the concept of a state independent dysfunction of indoleamines underlying bipolar illness.

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Author notes

  1. Anna Wirz-Justice

    Present address: Psychiatrische Universitätsklinik Basel, Switzerland

  2. W. Pühringer

    Present address: Wagner-Jauregg-Krankenhaus, Linz, Austria

Authors and Affiliations

  1. Psychiatrische Universitätsklinik Basel, Switzerland

    W. Pühringer

Authors
  1. Anna Wirz-Justice
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  2. W. Pühringer
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Wirz-Justice, A., Pühringer, W. Increased platelet serotonin in bipolar depression and hypomania. J. Neural Transmission 42, 55–62 (1978). https://doi.org/10.1007/BF01262729

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  • DOI: https://doi.org/10.1007/BF01262729

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