Summary
Nearly 69% of nucleus ambiguus neurons in the anesthetized, artificially respired dog responded to nonpharmacological manipulations of arterial pressure (AP). All were active at resting AP, most responded robustly to increased AP, and of these, about half showed activity modulated by the respiratory cycle. Other AP-sensitive neurons fired only during the inspiratory or expiratory phase of the pump-driven respiratory cycle, and were inhibited by increased AP and excited by decreased AP.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ciriello J, Calaresu FR (1980) Distribution of vagal cardioinhibitory neurons in the medulla of the cat. Am J Physiol 238: R58-R64
Delgado-Garcia JM, Lopez-Barneo J, Serra R, Gonzalez-Baron S (1983) Electrophysiological and functional identification of different neuronal types within the nucleus ambiguus in the cat. Brain Res 277: 231–240
Felsten G, Cook JA, Thompson ME, Natelson BH (1987) Recordings from arterial pressuresensitive units in the awake dog. Brain Res Bull 19: 75–80
Hopkins DA, Armour JA (1982) Medullary cells of origin of physiologically identified cardiac nerves in the dog. Brain Res Bull 8: 359–365
Hopkins DA, Armour JA (1984) Localization of sympathetic and parasympathetic preganglionic neurons which innervate different regions of the dog heart. J Comp Neurol 229: 186–198
Jewett JL (1964) Activity of single efferent fibres in the cervical vagus of the dog, with special reference to possible cardioinhibitory fibres. J Physiol 175: 321–357
Kalia M, Mesulam MM (1980) Brain stem projections of sensory and motor components of the vagus complex in the cat. II. Laryngeal, tracheobronchial, pulmonary, cardiac, and gastrointestinal branches. J Comp Neurol 193: 467–508
Katona PG, Poitras JW, Barnett GO, Terry BS (1970) Cardiac vagal efferent activity and heart period in the carotid sinus reflex. Am J Physiol 218: 1030–1037
Lipski J, McAllen RM, Trzebski A (1976) Carotid baroreceptor and chemoreceptor inputs onto single medullary neurones. Brain Res 107: 132–136
McAllen RM, Spyer KM (1976) The location of cardiac vagal preganglionic motoneurones in the medulla of the cat. J Physiol 258: 187–204
McAllen RM, Spyer KM (1978) Two types of vagal preganglionic motoneurones projecting to the heart and lungs. J Physiol 282: 353–364
McAllen RM, Spyer KM (1978) The baroreceptor input to cardiac vagal motoneurones. J Physiol 282: 365–374
Tapp WN, Holaday JW, Natelson BH (1984) Ultradian glucocorticoid rhythms in monkeys and rats during stress. Am J Physiol 247: 66-R871
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Felsten, G., Thompson, M.E., Cook, J.A. et al. Responses of nucleus ambiguus neurons to arterial pressure manipulations. J. Neural Transmission 78, 271–278 (1989). https://doi.org/10.1007/BF01249235
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01249235