Summary
Two virus strains, F and Ortlieb, which were presumably isolated from patients in Western Germany suffering from illnesses with varying symptomatology, including encephalomyelitis and myocarditis, produced paralysis in rhesus and cynomolgus monkeys. On histological examination of intracerebrally inoculated monkeys, a disseminated encephalomyelitis and myocarditis were found, the anterior horn lesions in the spinal cord closely resembling those in experimental poliomyelitis. On peripheral inoculation, the pathological picture resembled more that of poliomyelitis. The viruses were also pathogenic for mice and guinea pigs, they agglutinated sheep red cells and human 0 cells, and they appeared to be immunologically closely related to Columbia SK virus as shown in cross-neutrali-zation and haemagglutination-inhibition tests. The fact, that the strains differed from Columbia SK virus in their pathogenicity for rhesus monkeys, and failed to grow in the chick-embryo, is circumstantial evidence against their being derived from laboratory contamination with Columbia SK virus.
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Aided by a grant from the Dr.Simon Baruch Foundation, New York, USA and from the National Health Research Council T. N. O., The Hague, Netherlands.
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Verlinde, J.D., Hofman, B. Pathogenic and immunologic properties of two new members of the Columbia SK group of viruses. Archiv f Virusforschung 5, 14–26 (1952). https://doi.org/10.1007/BF01245136
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DOI: https://doi.org/10.1007/BF01245136