Skip to main content
Log in

Experimental genital infection of cebus monkeys with oral and genital isolates of herpesvirus hominis types 1 and 2

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

Experimental infection of the cebus monkey genital tract was demonstrated following the intravaginal inoculation of oral and genital strains ofHerpesvirus hominis. This was determined by the appearance of clinical lesions, isolation of virus and production of neutralizing antibody.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Nahmias, A. J., andW. R. Dowdle: Antigenic and biologic differences in herpesvirus hominis. Progr. med. Virol.10, 110–159 (1968).

    Google Scholar 

  2. Rawls, W. B., D. Laurel, J. L. Melnick, J. J. Glocksman, andR. H. Kaufman: A search for viruses in smegma, premalignant and early malignant cervical tissues. The isolation of herpesviruses with distinct antigenic properties. Amer. J. Epidem.87, 647–655 (1968).

    Google Scholar 

  3. Schneweis, K. E.: Die Typen 1 und 2 des Herpes-simplex-Virus bei verschiedenen Krankheitsbildern. Dtsch. med. Wschr.92, 2313–1314 (1967).

    PubMed  Google Scholar 

  4. Naib, Z. M., A. J. Nahmias, W. E. Josey, andJ. H. Wheeler: Association of maternal genital herpetic infection with spontaneous abortion. Obstet. and Gynec.35, 260–263 (1970).

    Google Scholar 

  5. Nahmias, A. J., C. A. Alford, andS. B. Korones: Infection of the newborn withherpesvirus hominis. Advanc. Pediat.17, 185–226 (1970).

    Google Scholar 

  6. Aurelian, L., I. Royston, andH. J. Davis: Antibody to genital herpes simplex virus: Association with cervical atypia and carcinomain situ. J. nat. Cancer Inst.45, 455–464 (1970).

    PubMed  Google Scholar 

  7. Josey, W. E., A. J. Nahmias, andZ. M. Naib: Genital infection with type 2 herpesvirus hominis: Present knowledge and possible relation to cervical cancer. Amer. J. Obstet. Gynec.101, 718–729 (1968).

    Google Scholar 

  8. Rawls, W. E., W. A. F. Tomkins, M. Figueroa, andJ. L. Melnick: Herpesvirus type 2: Association with carcinoma of the cervix. Science161, 1255–1256 (1968).

    PubMed  Google Scholar 

  9. Aurelian, L., J. D. Standberg, L. V. Melendez, andL. A. Johnson: Herpesvirus type 2 isolated from cervical tumor cells grown in tissue culture. Science174, 704–707 (1971).

    PubMed  Google Scholar 

  10. Nahmias, A. J., W. T. London, L. W. Catalano, D. A. Fuccillo, J. L. Sever, and C. Graham: Genital herpesvirus hominis type 2 infection: An experimental model in cebus monkeys. Science171, 297–298 (1971).

    PubMed  Google Scholar 

  11. London, Wm. T., L. W. Catalano, Jr.,A. J. Nahmias, D. A. Fuccillo, andJ. L. Sever: Genital herpesvirus hominis type 2 infection of monkeys. Obstet. and Gynec.37, 501–509 (1971).

    Google Scholar 

  12. Kalter, S. S., P. J. Felsburg, R. L. Heberling, A. J. Nahmias, andM. Brack: Experimentalherpesvirus hominis type 2 infection in nonhuman primates. Proc. Soc. exp. Biol. (N.Y.)139, 964–968 (1972).

    Google Scholar 

  13. Figueroa, M. C., andW. E. Rawls: Biological markers for differentiation of herpesvirus strains of oral and genital origin. J. gen. Virol.4, 259–267 (1969).

    PubMed  Google Scholar 

  14. Helmke, R. J., R. L. Heberling, andS. S. Kalter: Technique for viral neutralization antibody surveys in primary microcultures. Appl. Microbiol.20, 986–988 (1970).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This study was funded in part by U.S.P.H.S. grants RR 05519, RR 00278, RR 00361, RR 00451 and contracts NTH 69-93 and 71-2348 and WHO grant Z 2/181/27.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Felsburg, P.J., Heberling, R.L. & Kalter, S.S. Experimental genital infection of cebus monkeys with oral and genital isolates of herpesvirus hominis types 1 and 2. Archiv f Virusforschung 39, 223–227 (1972). https://doi.org/10.1007/BF01241544

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01241544

Keywords

Navigation