Abstract
It was established, in experiments on isolated spinal ganglia of adult rats in concluons of intracellular recording, that dopamine (1 μM/liter) elicits depolarized responses in 61% of neurons, hyperpolarized in 20% of neurons, and depolarized-hyperpolarized in 19% of neurons. The depolarized responses are associated with the activation of D1 dopamine receptors, and are governed by the shift of cAMP-dependent cation (sodium) channels to the conducting state. The hyperpolarized responses are triggered by the activation of D2 dopamine receptors, which by means of HTP-binding protein convert the potassium channels to the conducting state. The change in the polarization of neurons with the action of dopamine influences their electrical excitability variously.
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Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 76, No. 6, pp. 739–745, June, 1990.
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Abramets, I.I., Samoilovich, I.M. Analysis of two types of dopaminergic responses of neurons of the spinal ganglia of rats. Neurosci Behav Physiol 21, 435–440 (1991). https://doi.org/10.1007/BF01200278
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DOI: https://doi.org/10.1007/BF01200278