Skip to main content
SpringerLink
Log in

Participation of nucleic acids in conditioning; An ontogenetic investigation

  • Published:
Neuroscience Translations Aims and scope Submit manuscript

Conclusions

  1. 1.

    Subdural injection of ribonuclease, desoxyribonuclease and actinomycin C impedes formation of new conditioned reflexes. This effect is most marked in the early stages of postnatal ontogenesis.

  2. 2.

    After ribonuclease injection the RNA content of cortical neurons is reduced, but inborn reflexes are not thereby affected.

  3. 3.

    Subdural injection of desoxyribonuclease affects neither innate nor acquired (conditioned) reflexes.

  4. 4.

    Injection of control preparations (inactivated ribonuclease, trypsin, serum albumin and physiological salt solution) does not affect the studied parameters of conditioned-reflex activity.

  5. 5.

    Injection of ribonuclease, like injection of yeast RNA and serum albumin, does not affect the respiratory exchange of mice, but injection of chlorpromazine or thyroidectomy lowers the respiratory exchange by more than 50% compared with normal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. BYKOV, V. D. Zh. Vyssh. Nerv. Deyatelnosti im. I. P. Pavlova 10:101, 1960.

    Google Scholar 

  2. KRYLOV, O. A. Proc. 10th Congr. All-Union Physiol. Soc. Erevan, 1964, Vol. 2. p. 432; Proc. 7th Sci. Conf. Probl. Age Morphol. Physiol. Biochem., Moscow, 1965, p. 356.

    Google Scholar 

  3. KRYLOV, O. A., R. A. DANILOVA and V. S. TONGUR. Zh. Vyssh. Nerv. Deyatelnosti im. I. P. Pavlova 15:79, 1965.

    Google Scholar 

  4. KRYLOV, O. A., R. A. DANILOVA and V. S. TONGUR. Abstracts of Proceedings of the 4th Scientific Conference on Evolutionary Physiology, in memory of L. A. Orbeli. Leningrad, 1965, p. 161.

  5. KRYLOV, O. A., V. S. TONGUR and R. A. DANILOVA. Usp. Sovrem. Biol. 60:337, 1965.

    Google Scholar 

  6. LINKOVSKII, G. B. Biofizika 5:655, 1960.

    Google Scholar 

  7. MAGOUN, H. W. The Waking Brain. Springfield, 1958.

  8. SZENT-GYÖRGYI, A. Bioenergetics. Moscow, 1960.

  9. ASHBY, W. R. Design for a Brain. London, 1960.

  10. APPEL, S. H. Nature 207:1163, 1965.

    Google Scholar 

  11. BABICH, F. R., A. L. JACOBSON and S. BUBASH Proc. Nat. Acad. Sci. U.S.A. 54:1299, 1965.

    Google Scholar 

  12. CAMERON, D. E. and Z. SOLYOM. Geriatrics 16:74, 1961.

    Google Scholar 

  13. HYDÉN, H. Sci. Amer. 205:62, 1961; Angew. Chem. 76:720, 1964.

    Google Scholar 

  14. HYDÉN, H. and E. EGYHAZI. Proc. Nat. Acad. Sci. U.S.A. 52:1030, 1964.

    Google Scholar 

  15. JACOBSON, A. L., F. R. BABICH, S. BUBASH, and A. JACOBSON. Science 150: 636, 1965.

    Google Scholar 

  16. KRYLOV, O. A., R. A. DANILOVA and V. S. TONGUR, Life Sci. 4:1313, 1965.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Brain Institute and Institute of Biological and Medical Chemistry, USSR Academy of Medical Sciences, USSR

    O. A. Krylov, R. A. Danilova & V. S. Tongur

Authors
  1. O. A. Krylov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. Danilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. S. Tongur
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krylov, O.A., Danilova, R.A. & Tongur, V.S. Participation of nucleic acids in conditioning; An ontogenetic investigation. Neurosci Behav Physiol 2, 523–528 (1968). https://doi.org/10.1007/BF01125443

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01125443

Keywords

Search

Navigation