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Effect of multiple-stress procedures on monkey gastroduodenal mucosa, serum gastrin, and hydrogen ion kinetics

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Abstract

By arranging a series of psychological contingencies (unpredictability, uncontrollability, conflict), coupled with delivery of a physical stimulus (electric shock), we produced gastroduodenal mucosal lesions in 7 of 8 rhesus monkeys. The most severe conflict paradigm most consistently produced lesions across subjects. Of the 30 lesions observed by endoscopy, 80% occurred near the anatomic junction of gastric body and antrum, in the antrum, or in the duodenum. Lesions varied in severity from discolorations of the mucosa to disruptions of mucosal integrity. Lesions in the stomach generally disappeared in several days despite the continuation of stress; some duodenal lesions were equally evanescent, but in 2 monkeys, lesions lasted over a week. Hydrogen ion kinetics were measured in 2 monkeys that developed gastric lesions and 2 that developed duodenal lesions. The rate at which hydrogen ion entered the duodenum was uniformly suppressed for all 4 monkeys during their first session of shock avoidance; during their last session, the gastric subgroup continued to show suppression while the duodenal subgroup returned towards control levels. Serum gastrin levels were unchanged by the multiple-stress procedures. Our finding of consistently producible, stress-induced gastroduodenal pathology in anatomic areas similar to those involved in man suggests that the subhuman primate is suitable for further efforts to produce an animal model of psychosomatic ulcer disease.

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Author notes

  1. André Dubois MD

    Present address: Department of Internal Medicine, Uniformed Services University of The Health Sciences, NNMC, Bethesda, Maryland

Authors and Affiliations

  1. Veterans Administration Hospital and Department of Neurosciences, New Jersey Medical School, 88 Ross Street, 07018, East Orange, New Jersey

    Benjamin H. Natelson MD, André Dubois MD & Frank J. Spdetz Ph.D.

  2. Digestive Diseases Branch, National Institute of Health, Bethesda, Maryland

    Benjamin H. Natelson MD, André Dubois MD & Frank J. Spdetz Ph.D.

  3. Department of Experimental Psychology, Walter Reed Army Institute of Research, Washington, D.C.

    Benjamin H. Natelson MD, André Dubois MD & Frank J. Spdetz Ph.D.

Authors
  1. Benjamin H. Natelson MD
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  2. André Dubois MD
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  3. Frank J. Spdetz Ph.D.
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Additional information

This research was supported in part by funds to B.H.N. from the Medical Research Service of the Veterans Administration.

In conducting the research described in this paper, the investigators adhered to the “Guide for Laboratory Animal Facilities and Care,” as promulgated by the Committee on the Revision of the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences—National Research Council.

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Natelson, B.H., Dubois, A. & Spdetz, F.J. Effect of multiple-stress procedures on monkey gastroduodenal mucosa, serum gastrin, and hydrogen ion kinetics. Digest Dis Sci 22, 888–897 (1977). https://doi.org/10.1007/BF01076165

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