Abstract
The hepatic clearance of unconjugated bilirubin-14C from the plasma of 5 patients with cholestatic liver disease was normal when compared with values obtained in healthy young adults. In 1 patient with benign recurrent cholestasis, clearance was the same during an attack of cholestasis (serum bilirubin concentration 25.7 mg/100 ml) as when the patient was in remission (serum bilirubin concentration 0.65 mg/100 ml). We conclude that the hepatic clearance of unconjugated bilirubin may not be altered in hepatic disorders where cholestasis is the predominant feature and that other explanations should be considered when patients with these disorders manifest an increased plasma concentration of unconjugated bilirubin.
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the Metabolism Branch, National Cancer Institute, National Institutes of Health.
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Bloomer, J.R., Berk, P.D. & Howe, R.B. Hepatic clearance of unconjugated bilirubin in cholestatic liver diseases. Digest Dis Sci 19, 9–14 (1974). https://doi.org/10.1007/BF01073348
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DOI: https://doi.org/10.1007/BF01073348