Skip to main content
SpringerLink
Log in

Diagnosis of Barrett's esophagus by pertechnetate radionuclide

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

In Barrett's esophagus the normal stratified squamous epithelium of esophagus is replaced by columnar epithelium and other chracteristics of gastric mucosa. Barrett's esophagus has an increased tendency to bleed and is more prone to undergo malignant change. There are many procedures used to diagnose this entity, but only by serial and multiple esophageal mucosal biopsies can the diagnosis be confirmed. Harper et al (8) demonstrated an early and intense uptake of 99m Tc pertechnetate by the stomach in animals. Since the Barrett's esophagus is lined by gastric mucosa, pertechnetate scintigraphy was used as a screening procedure. The criteria for a positive scan was an area of increased uptake of technetium extending above the normal dense uptake of stomach configuration. Pertechnetate scintigraphy was performed in 4 patients with Barrett's esophagus and 6 controls with only one false negative result. Thus pertechnetate scintigraphy is a rapid, safe, and atraumatic screening procedure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barrett NR: Chronic peptic ulcer of the oesophagus and oesophagitis. Br J Surg 38:175–182, 1950

    Google Scholar 

  2. Mangla JC, Kim YM, Guarasci G, Schenk EA: Pepsinogens in epithelium of Barrett's oesophagus. Gastroenterology 65:949–955, 1973

    Google Scholar 

  3. Goldman MC, Beckman RC: Barrett syndrome: Case report with discussion about concepts of pathogenesis. Gastroenterology 39:104–110, 1960

    Google Scholar 

  4. Desbaillets LG, Mangla JC: Endoscopic diagnosis of Barrett's esophagus. Endoscopy (to be published)

  5. Adler RH, Rodriguez J: The association of hiatus hernia and gastroesophageal malignancy. J Thorac Surg 37:553, 1959

    Google Scholar 

  6. Smithers DW: Adenocarcinoma of the oesophagus. Thorax 11:257, 1956

    Google Scholar 

  7. Burgess JN, Payne WS, Andersen HA, Weiland LH, Carlson HC: Barrett esophagus: The columnar-epithelial-lined lower esophagus. Mayo Clin Proc 46:728–734, 1971

    Google Scholar 

  8. Harper PV, Andros G, Lathrop KA: Preliminary observations on the use of six-hour Tc99m as a tracer in biology and medicine. Semiannual report to the Atomic Energy Commission, September 1962. LO Jacobson (ed). ACRH-18, pp 76–87

  9. Harden RMcG, Alexander WD, Kennedy I: Isotope uptake and scanning of the stomach in man with99mTc-pertechnetate. Lancet 1:1305–1307, 1967

    Google Scholar 

  10. Jewett TC Jr, Duszynski DO, Allen JE: The visualization of Meckel's diverticulum with99mTc-pertechnetate. Surgery 68:567–570, 1970

    Google Scholar 

  11. Duszynski DO, Jewett TC, Allen JE: Tc99mNa pertechnetate scanning of the abdomen with particular reference to small bowel pathology. Am J Roentgenol Radium Ther Nucl Med 113:250–262, 1971

    Google Scholar 

  12. Berquist TH, Nolan NG, Carlson HC, Stephens DH: Diagnosis of Barrett's esophagus by pertechnetate scintography. Mayo Clin Proc 48:276–279, 1973

    Google Scholar 

  13. Perlman J, Ruben S, Chaikoff IL: Radioactive phosphorus as an indicator of phospholipid metabolism. I. The rate of formation and destruction of phospholipids in the fasting rat. J Biol Chem 122:169–182, 1938

    Google Scholar 

  14. Jones HB, Chaikoff IL, Lawrence JH: Radioactive phosphorus as an indicator of phospholipid metabolism. X. The phospholipid turnover of fraternal tumors. J Biol Chem 133:319–327, 1944

    Google Scholar 

  15. Nakayama K: Diagnostic significance of radioactive isotopes in early cancer of the alimentary tract, especially the esophagus and the cardia. Surgery 39:736–759, 1956

    Google Scholar 

  16. Clode WH, Sobral JMV, Lima Basto E, Baptista AM: Elective uptake of radioiodine by cancer of the stomach. Surgery 50:725, 1961

    Google Scholar 

  17. Czerniak P, Bank H, Sinkower A, Adams R: Usefulness of radionuclides in evaluation of stomach disorders. Semin Nuclear Med 2:288–301, 1972

    Google Scholar 

  18. Marsden DS, Alexander C, Yeung P, Dunn A, Lazarevic B: Autoradiographic explanation for the uses of99mTc in gastric scintophotography. J Nucl Med 14:632, 1973

    Google Scholar 

  19. Gilday DL, Rosenthall L, Duszynski DO, James AE: Abdominal imaging in pediatrics. Pediatric Nuclear Medicine. AE James, HN Wagner, RE Cooke (eds). Philadelphia, W. B. Saunders, 1974, pp. 298–307

    Google Scholar 

  20. Meier-Ruge W, Fridrich R: Die verteilung von technetium99mund Tod-131 in her magenschleinhut. Histochemie 19: 147–154, 1969

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Monroe Community Hospital (affiliated with The University of Rochester School of Medicine and Dentistry), 435 East Henrietta Road, 14603, Rochester, New York

    Jagdish C. Mangla MD, FRCP(C), FACP (Director of Gastroenterology) & Manuel Brown MD

Authors
  1. Jagdish C. Mangla MD, FRCP(C), FACP
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manuel Brown MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mangla, J.C., Brown, M. Diagnosis of Barrett's esophagus by pertechnetate radionuclide. Digest Dis Sci 21, 324–328 (1976). https://doi.org/10.1007/BF01071845

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01071845

Keywords

Search

Navigation