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Frontiers in inflammatory bowel disease

The proceedings of a conference sponsored by the McReynolds foundation part II

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References: Part II

  1. Jayson MIV, Salmon PR, Harrison WJ: Inflammatory bowel disease in ankylosing spondylitis. Gut 11:506–511, 1970

    Google Scholar 

  2. Ritchie JK, Allan RN, Macartney J, Thompson H, Hawley PR, Cooke WT: Biliary tract carcinoma associated with ulcerative colitis. Q J Med ns 43:263–279, 1974

    Google Scholar 

  3. Eade MN: Liver disease in ulcerative colitis. I. Analysis of operative liver biopsy in 138 consecutive patients having colectomy. Ann Intern Med 72:475–487, 1970

    Google Scholar 

  4. Eade MN, Cooke WT, Brooke BN: Liver disease in ulcerative colitis. II. The long-term effect of colectomy. Ann Intern Med 72:489–497, 1970

    Google Scholar 

  5. Rogers RS III, Sams WM Jr, Shorter RG: Lymphocytotoxicity in recurrent aphthous stomatitis: lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Behcet syndrome. Arch Dermatol 109:361–363, 1974

    Google Scholar 

  6. Mendeloff AI, Monk M, Siegel CI, Lilienfeld A: Some epidemiological features of ulcerative colitis and regional enteritis: a preliminary report. Gastroenterology 51:748–752, 1966

    Google Scholar 

  7. Haslock I, Wright V: Arthritis and intestinal disease. J R Coll Physicians Lond 8:154–162, 1974

    Google Scholar 

  8. Berglöf F-E: Arthritis and intestinal infection. Acta Rheum Scand 9:141–149, 1963

    Google Scholar 

  9. Reiter H: Ueber eine bisher unerkannte Spirochäteninfektion (Spirochaetosis arthritica). Dtsch Med Wochenschr 42:1535–1536, 1916

    Google Scholar 

  10. Paronen I: Reiter's disease: a study of 344 cases observed in Finland. Acta Med Scand [Suppl 212] 131:1–114, 1948

    Google Scholar 

  11. Von Pirquet C, Schick B: Die Serumkrankheiten. Leipzig, F. Deuticke, 1905

    Google Scholar 

  12. Harrison WJ: Autoantibodies against intestinal and gastric mucous cells in ulcerative colitis. Lancet 1:1346–1350, 1965

    Google Scholar 

  13. Lagercrantz R, Hammarström S, Perlmann P, Gustafsson BE: Immunological studies in ulcerative colitis. III. Incidence of antibodies to colon-antigen in ulcerative colitis and other gastro-intestinal diseases. Clin Exp Immunol 1:263–276, 1966

    Google Scholar 

  14. Koffler D, Minkowitz S, Rothman W, Garlock J: Immunocytochemical studies in ulcerative colitis and regional ileitis. Am J Pathol 41:733–745, 1962

    Google Scholar 

  15. Monteiro E, Fossey J, Shiner M, Drasar BS, Allison AC: Antibacterial antibodies in rectal and colonic mucosa in ulcerative colitis. Lancet 1:249–251, 1971

    Google Scholar 

  16. Benacerraf B, Sebestyen M, Cooper NS: The clearance of antigen antibody complexes from the blood by the reticulo-endothelial system. J Immunol 82:131–137, 1959

    Google Scholar 

  17. Cochrane CG: Mechanisms involved in the deposition of immune complexes in tissues. J Exp Med 134 Part 2:75s-89s, 1971

    Google Scholar 

  18. MacLennan ICM: Competition for receptors for immunoglobulin on cytotoxic lymphocytes. Clin Exp Immunol 10:275–283, 1972

    Google Scholar 

  19. Jewell DP, MacLennan ICM: Circulating immune complexes in inflammatory bowel disease. Clin Exp Immunol 14:219–226, 1973

    Google Scholar 

  20. Doe WF, Brown D: Evidence for circulating immune complexes in inflammatory bowel disease and adult coeliac disease (abstract). Gut 14:429, 1973

    Google Scholar 

  21. Phillips-Quagliata JM, Levine BB, Quagliata F, Uhr JW: Mechanisms underlying binding of immune complexes to macrophages. J Exp Med 133:589–601, 1971

    Google Scholar 

  22. Huber H, Polley MJ, Linscott WD, Fudenberg HH, Müller-Eberhard HJ: Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G. Science 162:1281–1283, 1968

    Google Scholar 

  23. Henson PM: Interaction of cells with immune complexes: adherence, release of constituents, and tissue injury. J Exp Med 134 Part 2:114s-135s, 1971

    Google Scholar 

  24. Macrae I, Wright V: A family study of ulcerative colitis: with particular reference to ankylosing spondylitis and sacroiliitis. Ann Rheum Dis 32:16–20, 1973

    Google Scholar 

  25. Haslock I: The arthritis associated with Crohn's disease: a family study (abstract). Rheumatol Rehabil 12:93, 1973

    Google Scholar 

  26. Sherlock P, Bell BM, Steinberg H, Almy TP: Familial occurrence of regional enteritis and ulcerative colitis. Gastroenterology 45:413–420, 1963

    Google Scholar 

  27. Hersh AH, Stecher RM, Solomon WM, Wolpaw R, Hauser H: Heredity in ankylosing spondylitis: a study of fifty families. Am J Hum Genet 2:391–408, 1950

    Google Scholar 

  28. Emery AE, Lawrence JS: Genetics of ankylosing spondylitis. J Med Genet 4:239–244, 1967

    Google Scholar 

  29. Caffrey MFP, James DCO: Human lymphocyte antigen association in ankylosing spondylitis (letter to the editor). Nature 242:121, 1973

    Google Scholar 

  30. Schlosstein L, Terasaki PI, Bluestone R, Pearson CM: High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med 288:704–706, 1973

    Google Scholar 

  31. Scott BB, Swinburne ML, Rajah SM, Losowsky MS: HL-A8 and the immune response to gluten. Lancet 2:374–377, 1974

    Google Scholar 

  32. Brewerton DA, Caffrey M, Nicholls A, Walters D, James DCO: HL-A 27 and arthropathies associated with ulcerative colitis and psoriasis. Lancet 1:956–958, 1974

    Google Scholar 

  33. Crohn BB, Rosenberg H. The sigmoidoscopic picture of chronic ulcerative colitis (non-specific). Am J Med Sci 170:220–228, 1925

    Google Scholar 

  34. Yeomans FC: Carcinomatous degeneration of rectal adenomas: report of seven cases. JAMA 89:852–854, 1927

    Google Scholar 

  35. Bargen JA: Chronic ulcerative colitis complicated by malignant neoplasia. Proc Staff Meet Mayo Clin 3:132–134, 1928

    Google Scholar 

  36. Felsen J, Wolarsky W: Chronic ulcerative colitis and carcinoma. Arch Intern Med 84:293–304, 1949

    Google Scholar 

  37. Otani S, Snapper I: On the incidence of carcinoma in chronic ulcerative colitis. J Mt Sinai Hosp 19:275–288, 1952

    Google Scholar 

  38. Sloan WP Jr, Bargen JA, Gage RP: Life histories of patients with chronic ulcerative colitis: review of 2,000 cases. Gastroenterology 16:25–38, 1950

    Google Scholar 

  39. Goldgraber MB, Humphreys EM, Kirsner JB, Palmer WL: Carcinoma and ulcerative colitis: a clinical-pathologic study. I. Cancer deaths. Gastroenterology 34:809–839, 1958

    Google Scholar 

  40. De Dombal FT, Watts JM, Watkinson G, Goligher JC: Local complications of ulcerative colitis: stricture, pseudopolyposis and carcinoma of the colon and rectum. Br Med J 1:1442–1447, 1966

    Google Scholar 

  41. MacDougall IPM: The cancer risk in ulcerative colitis. Lancet 2:655–658, 1964

    Google Scholar 

  42. Hinton JM: Risk of malignant change in ulcerative colitis. Gut 7:427–432, 1966

    Google Scholar 

  43. Devroede GJ, Taylor WF, Sauer WG, Jackman RJ, Stickler GB: Cancer risk and life expectancy of children with ulcerative colitis. N Engl J Med 285:17–21, 1971

    Google Scholar 

  44. Goldgraber MB, Kirsner JB: Carcinoma of the colon in ulcerative colitis. Cancer 17:657–665, 1964

    Google Scholar 

  45. Welch CE, Hedberg SE: Colonic cancer in ulcerative colitis and idiopathic colonic cancer. JAMA 191:815–818, 1965

    Google Scholar 

  46. Lindner AE, Marshak RH, Wolf BS, Janowitz HD: Granulomatous colitis: a clinical study. N Engl J Med 269:379–385, 1963

    Google Scholar 

  47. Farmer RG, Hawk WA, Turnbull RB Jr: Regional enteritis of the colon: a clinical and pathologic comparison with ulcerative colitis. Am J Dig Dis 13:501–514, 1968

    Google Scholar 

  48. Lennard-Jones JE, Lockhart-Mummery HE, Morson BC: Clinical and pathological differentiation of Crohn's disease and proctocolitis. Gastroenterology 54:1162–1170, 1968

    Google Scholar 

  49. Zetzel L: Granulomatous (ileo) colitis. N Engl J Med 282:600–605, 1970

    Google Scholar 

  50. Ginzburg L, Schneider KM, Dreizin DH, Levinson C: Carcinoma of the jejunum occurring in a case of regional enteritis. Surgery 39:347–351, 1956

    Google Scholar 

  51. Sheil FO, Clark CG, Goligher JC: Adenocarcinoma associated with Crohn's disease. Br J Surg 55:53–58, 1968

    Google Scholar 

  52. Cantwell JD, Kettering RF, Carney JA, Ludwig J: Adenocarcinoma complicating regional enteritis: report of a case and review of the literature. Gastroenterology 54:599–604, 1968

    Google Scholar 

  53. Morowitz DA, Block GE, Kirsner JB: Adenocarcinoma of the ileum complicating chronic regional enteritis. Gastroenterology 55:397–402, 1968

    Google Scholar 

  54. Tyers GFO, Steiger E, Dudrick SJ: Adenocarcinoma of the small intestine and other malignant tumors complicating regional enteritis: case report and review of the literature. Ann Surg 169:510–518, 1969

    Google Scholar 

  55. Farmer RG, Hawk WA, Turnbull RB JJr: Carcinoma associated with regional enteritis: report of 2 cases. Am J Dig Dis 15:365–371, 1970

    Google Scholar 

  56. Goldman LI, Bralow, SP, Cox W, Peale AR: Adenocarcinoma of the small bowel complicating Crohn's disease. Cancer 26:1119–1125, 1970

    Google Scholar 

  57. Schuman BM: Adenocarcinoma arising in an excluded loop of ileum. N Engl J Med 283:136–137, 1970

    Google Scholar 

  58. Dikman SH, Toker, C.: Enteroblastoma complicating regional enteritis. Gastroenterology 65:462–466, 1973

    Google Scholar 

  59. Good CA: Tumors of the small intestine. Am J Roentgenol Radium Ther Nucl Med 89:685–705, 1963

    Google Scholar 

  60. Eckel JH: Primary tumors of the jejunum and ileum. Surgery 23:467–475, 1948

    Google Scholar 

  61. Bargen JA, Sauer WG, Sloan WP, Gage RP: The development of cancer in chronic ulcerative colitis. Gastroenterology 26:32–37, 1954

    Google Scholar 

  62. MacDougall IPM: Ulcerative colitis and carcinoma of the large intestine. Br Med J 1:852–854, 1954

    Google Scholar 

  63. Fielding JF, Prior P, Waterhouse JA, Cooke WT: Malignancy in Crohn's disease. Scand J Gastroenterol 7:3–7, 1972

    Google Scholar 

  64. Weedon DD, Shorter RG, Ilstrup DM, Huizenga KA, Taylor WF: Crohn's disease and cancer. N Engl J Med 289:1099–1103, 1973

    Google Scholar 

  65. Perrett AD, Truelove SC, Massarella GR: Crohn's disease and carcinoma of colon. Br Med J 2:466–468, 1968

    Google Scholar 

  66. Brill CB, Klein SF, Kark AE: Regional enteritis and entero-colitis: a study of 74 patients over 15 years. Ann Surg 170:766–774, 1969

    Google Scholar 

  67. Edwards FC, Truelove SC: The course and prognosis of ulcerative colitis. III. Complications. Gut 5:1–22, 1964

    Google Scholar 

  68. Sparberg M, Fennessy J, Kirsner JB: Ulcerative proctitis and mild ulcerative colitis: a study of 220 patients. Medicine (Baltimore) 45:391–412, 1966

    Google Scholar 

  69. Mayo CW, Fly OA Jr, Connelly ME: Fate of the remaining rectal segment after subtotal colectomy for ulcerative colitis. Ann Surg 144:753–757, 1856

    Google Scholar 

  70. Localio SA: Spontaneous disappearance of rectal polyps following subtotal colectomy and ileoproctostomy for polyposis of the colon. Am J Surg 103:81–82, 1962

    Google Scholar 

  71. Williams RD, Fish JC: Multiple polyposis, polyp regression, and carcinoma of the colon. Am J Surg 112:846–849, 1966

    Google Scholar 

  72. Aylett S: Cancer and ulcerative colitis. Br Med J 2:203–205, 1971

    Google Scholar 

  73. Svartz N, Ernberg T: Cancer coli in cases of colitis ulcerosa. Acta Med Scand 135:444–447, 1949

    Google Scholar 

  74. Bonnevie O, Riis P, Anthonisen P: An epidemiological study of ulcerative colitis in Copenhagen County. Scand J Gastroenterol 3:432–438, 1968

    Google Scholar 

  75. Maratka Z: Ulcerative colitis and carcinoma of the colon. Gastroenterology 40:854–855, 1961

    Google Scholar 

  76. Fahrländer H: Colitis ulcerosa: Übersicht anhand von 172 Fällen. Dtsch Med Wochenschr 91:1953–1959, 1966

    Google Scholar 

  77. Henning N: Carcinoma of the colon in ulcerative colitis: what is the risk? Ger Med Mon 12:402–403, 1967

    Google Scholar 

  78. Hillemand P, Verne J-M, Lebouc, Faivre: Recto-colite hémorragique et cancer. Arch Mal Appar Dig 44:577–581, 1955

    Google Scholar 

  79. Aktan H, Paykoç Z, Ertan A: Ulcerative colitis in Turkey: clinical review of sixty cases. Dis Colon Rectum 13:62–65, 1970

    Google Scholar 

  80. Matsunaga F, Yoshida Y, Okamoto K, Kawamura S: [Ulcerative colitis and cancer.] Naika 16:1077–1081, 1965

    Google Scholar 

  81. Doll R.: The geographical distribution of cancer. Br J Cancer 23:1–8, 1969

    Google Scholar 

  82. Burkitt DP: Epidemiology of cancer of the colon and rectum. Cancer 28:3–13, 1971

    Google Scholar 

  83. Zirkin RM, McCord DL: Squamous cell carcinoma of the rectum: report of a case complicating chronic ulcerative colitis. Dis Colon Rectum 6:370–373, 1963

    Google Scholar 

  84. Hohm WH, Jackman RJ: Squamous cell carcinoma of the rectum complicating ulcerative colitis: report of two cases. Mayo Clin Proc 39:249–251, 1964

    Google Scholar 

  85. Cornes JS, Smith JC, Southwood WFW: Lymphosarcoma in chronic ulcerative colitis: with report of two cases. Br J Surg 49:50–53, 1961

    Google Scholar 

  86. Sataline LR, Mobley EM, Kirkham W: Ulcerative colitis complicated by colonic lymphoma. Gastroenterology 44:342–347, 1963

    Google Scholar 

  87. Nugent FW, Zuberi S, Bulan MB, Legg MA: Colonic lymphoma in ulcerative colitis: report of four cases. Lahey Clin Found Bull 21:104–111, 1972

    Google Scholar 

  88. Hughes RK: Reticulum cell sarcoma: a case possibly originating in regional enteritis. Am Surg 21:770–773, 1955

    Google Scholar 

  89. Devroede GJ, Dockerty MB, Sauer WG, Jackman RJ, Stickler GB: Cancer of the colon in patients with ulcerative colitis since childhood. Can J Surg 15:369–374, 1972

    Google Scholar 

  90. Wood WJ, Archer R, Schaefer JW, Stephens C, Griffin WO Jr: Coexistence of regional enteritis and carcinoid tumor. Gastroenterology 59:265–269, 1970

    Google Scholar 

  91. Babb RR, Lee RH, Peck OC: Cancer of the bile duct and chronic ulcerative colitis. Am J Surg 119:337–339, 1970

    Google Scholar 

  92. Converse CF, Reagan JW, DeCosse JJ: Ulcerative colitis and carcinoma of the bile ducts. Am J Surg 121:39–45, 1971

    Google Scholar 

  93. Morowitz DA, Glagov S, Dordal E, Kirsner JB: Carcinoma of the biliary tract complicating chronic ulcerative colitis. Cancer 27:356–361, 1971

    Google Scholar 

  94. Ritchie JK, Hawley PR: Carcinoma of the biliary tract associated with ulcerative colitis (abstract). Gut 13:840–841, 1972

    Google Scholar 

  95. Ross AP, Braasch JW: Ulcerative colitis and carcinoma of the proximal bile ducts. Gut 14:94–97, 1973

    Google Scholar 

  96. Burnet FM: A modern basis for pathology. Lancet 1:1383–1387, 1968

    Google Scholar 

  97. Gatti RA, Good RA: Occurrence of malignancy in immunodeficiency diseases: a literature review. Cancer 28:89–98, 1971

    Google Scholar 

  98. Walker JG, Greaves MF: Delayed hypersensitivity and lymphocyte transformation in Crohn's disease and proctocolitis (abstract). Gut 10:414, 1969

    Google Scholar 

  99. Brown SM, Taub RN, Present DH, Janowitz HD: Short-term lymphocyte cultures in regional enteritis (letter to the editor). Lancet 1:1142, 1970

    Google Scholar 

  100. Parent K, Barrett J, Wilson ID: Investigation of the pathogenic mechanisms in regional enteritis with in vitro lymphocyte cultures. Gastroenterology 61:431–439, 1971

    Google Scholar 

  101. Asquith P, Kraft SC, Rothberg RM: Lymphocyte responses to nonspecific mitogens in inflammatory bowel disease. Gastroenterology 65:1–7, 1973

    Google Scholar 

  102. Jones JV, Housley J, Ashurst PM, Hawkins CF: Development of delayed hypersensitivity to dinitrochlorobenzene in patients with Crohn's disease. Gut 10:52–56, 1969

    Google Scholar 

  103. O'Toole CM, Davies AJS: Pre-emption in immunity. Nature 230:187–189, 1971

    Google Scholar 

  104. Smythe PM, Schonland M, Brereton-Stiles GG, Coovadia HM, Grace HJ, Loening WEK, Mafoyane A, Parent MA, Vos GH: Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet 2:939–944, 1971

    Google Scholar 

  105. Maclaurin BP, Cooke WT, Ling NR: Imparied lymphocyte reactivity against tumour cells in patients with Crohn's disease. Gut 13:614–620, 1972

    Google Scholar 

  106. Hughes LE, Mackay WD: Suppression of the tuberculin response in malignant disease. Br Med J 2:1346–1348, 1965

    Google Scholar 

  107. Whittaker MG, Rees K, Clark CG: Reduced lymphocyte transformation in breast cancer. Lancet 1:892–893, 1971

    Google Scholar 

  108. Chretien PB, Crowder WL, Gertner HR, Sample WF, Catalona WJ: Correlation of preoperative lymphocyte reactivity with the clinical course of cancer patients. Surg Gynecol Obstet 136:380–384, 1973

    Google Scholar 

  109. McIllmurray MB, Gray M, Langman MJS: Phytohaemagglutinin-induced lymphocyte transformation in patients before and after resection of large intestinal cancer. Gut 14:541–544, 1973

    Google Scholar 

  110. Edwards AJ, Rowland GF, Lee MR: Reduction of lymphocyte transformation by a factor produced by gastrointestinal cancer. Lancet 1:687–689, 1973

    Google Scholar 

  111. Klein E: Tumour immunology: escape mechanisms. Ann Inst Pasteur (Paris) 122:593–602, 1972

    Google Scholar 

  112. Bleiberg H, Mainguet P, Galand P, Chretien J, Dupont-Mairesse N: Cell renewal in the human rectum: in vitro autoradiographic study on active ulcerative colitis. Gastroenterology 58:851–855, 1970

    Google Scholar 

  113. Diaz RJ, Farmer RG, Brown CH: Carcinoma of the colon and ulcerative colitis. Am J Dig Dis 10:643–656, 1965

    Google Scholar 

  114. Kaliss N: Immunological enhancement of tumor homografts in mice: a review. Cancer Res 18:992–1003, 1958

    Google Scholar 

  115. LeBel JS, Deodhar SD, Brown CH: Evaluation of a radioimmunoassay for carcinoembryonic antigen of the human digestive system. Cleve Clin Q 39:25–31, 1972

    Google Scholar 

  116. Rule AH, Straus E, Vandevoorde J, Janowitz HD: Tumor-associated (CEA-reacting) antigen in patients with inflammatory bowel disease. N Engl J Med 287:24–26, 1972

    Google Scholar 

  117. Turner MD, Kleinman MS, Thayer W: Serum carcinoembryonic antigen (CEA) in patients with chronic inflammatory bowel disease. Digestion 9:116–123, 1973

    Google Scholar 

  118. Gold P: Embryonic origin of human tumor-specific antigens. Prog Exp Tumor Res 14:43–58, 1971

    Google Scholar 

  119. Baldwin RW, Embleton MJ, Price MR: Inhibition of lymphocyte cytotoxicity for human colon carcinoma by treatment with solubilized tumour membrane fractions. Int J Cancer 12:84–92, 1973

    Google Scholar 

  120. Apffel CA, Peters JH: Tumors and serum glycoproteins: the ‘symbodies’. Prog Exp Tumor Res 12:1–54, 1969

    Google Scholar 

  121. Dearing WH, McGuckin WF, Elveback LR: Serum α1-acid glycoprotein in chronic ulcerative colitis. Gastroenterology 56:295–303, 1969

    Google Scholar 

  122. Klein G: Tumor immunology. Transplant Proc 5:31–41, 1973

    Google Scholar 

  123. Middleton WRJ: Small bowel tumours. Aust Ann Med 16:155–160, 1967

    Google Scholar 

  124. Hellström KE, Hellström I: Cellular immunity against tumor antigens. Adv Cancer Res 12:167–223, 1969

    Google Scholar 

  125. Nairn RC, Nind APP, Guli EPG, Davies DJ, Rolland JM, McGiven AR, Hughes ESR. Immunological reactivity in patients with carcinoma of colon. Br Med J 4:706–709, 1971

    Google Scholar 

  126. Baldwin RW, Embleton MJ, Jones JSP, Langman MJS: Cell-mediated and humoral immune reactions to human tumours. Int J Cancer 12:73–83, 1973

    Google Scholar 

  127. Gold P, Freedman SO: Specific carcinoembryonic antigens of the human digestive system. J Exp Med 122:467–481, 1965

    Google Scholar 

  128. Von Kleist S, Burtin P: Isolation of a fetal antigen from human colonic tumors. Cancer Res 29:1961–1964, 1969

    Google Scholar 

  129. Gold P, Krupey J, Ansari H: Position of the carcinoembryonic antigen of the human digestive system in ultrastructure of tumor cell surface. J Natl Cancer Inst 45:219–225, 1970

    Google Scholar 

  130. Lejtenyi MC, Freedman SO, Gold P: Response of lymphocytes from patients with gastrointestinal cancer to the carcinoembryonic antigen of the human digestive system. Cancer 28:115–120, 1971

    Google Scholar 

  131. Stewart THM: The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors. I. The role of tissue antigen, nonspecific reactions of nuclear material, and bacterial antigen as a cause for this phenomenon. Cancer 23:1368–1379, 1969

    Google Scholar 

  132. Helwig FC: Cytoplasmic inclusion bodies in chronic ulcerative colitis: their relationship to polyps and cancer of the colon and rectum. Dis Colon Rectum 1:270–275, 1958

    Google Scholar 

  133. Helwig FC: Epithelial cytoplasmic inclusion bodies of possible viral origin in clinically early ulcerative colitis. Dis Colon Rectum 2:23–26, 1959

    Google Scholar 

  134. Monis B, Mendeloff AI: Observations on inclusion bodies in normal and pathological mucosa of the colon in man. J Natl Cancer Inst 26:1429–1443, 1961

    Google Scholar 

  135. Mendeloff AI: Inclusion bodies, ulcerative colitis, and neoplasia (editorial). Gastroenterology 43:351–352, 1962

    Google Scholar 

  136. Dobbins WO III, Siemers PT: A viral etiology for inflammatory bowel disease? (Abstract.) Gastroenterology 62:742, 1972

    Google Scholar 

  137. Powell RD, Warner NE, Levine RS, Kirsner JB: Cytomegalic inclusion disease and ulcerative colitis: report of a case in a young adult. Am J Med 30:334–340, 1961

    Google Scholar 

  138. Tamura H: Acute ulcerative colitis associated with cytomegalic inclusion virus. Arch Pathol 96:164–167, 1973

    Google Scholar 

  139. Klemola E, Kääriäinen L, von Essen R, Haltia K, Koivaniemi A, von Bonsdorff C-H: Further studies on cytomegalovirus mononucleosis in previously healthy individuals. Acta Med Scand 182:311–322, 1967

    Google Scholar 

  140. Heine U, Kondratick J, Ablashi DV, Armstrong GR, Dalton AJ: Ultrastructural and biological properties of a cytomegalovirus rescued from a human paraganglioma. Cancer Res 31:542–549, 1971

    Google Scholar 

  141. Wynder EL, Shigematsu T: Environmental factors of cancer of the colon and rectum. Cancer 20:1520–1561, 1967

    Google Scholar 

  142. Gregor O, Toman R, Prušová F: Gastrointestinal cancer and nutrition. Gut 10:1031–1034, 1969

    Google Scholar 

  143. Cummings JH: Dietary fibre. Gut 14:69–81, 1973

    Google Scholar 

  144. Hill MJ, Crowther JS, Drasar BS, Hawksworth G, Aries V, Williams REO: Bacteria and aetiology of cancer of large bowel. Lancet 1:95–100, 1971

    Google Scholar 

  145. Reddy BS, Wynder EL: Large-bowel carcinogenesis: fecal constituents of populations with diverse incidence rates of colon cancer. J Natl Cancer Inst 50:1437–1442, 1973

    Google Scholar 

  146. Cook JW, Kennaway EL, Kennaway NM: Production of tumours in mice by deoxycholic acid (letter to the editor). Nature 145:627, 1940

    Google Scholar 

  147. Lacassagne A, Buu-Hoï NP, Zajdela F: Carcinogenic activity of apocholic acid (letter to the editor). Nature 190:1007–1008, 1961

    Google Scholar 

  148. Lacassagne A, Buu-Hoï NP, Zajdela F: Carcinogenic activityin situ of further steroid compounds (letter to the editor). Nature 209:1026–1027, 1966

    Google Scholar 

  149. Miettinen TA: The role of bile salts in diarrhoea of patients with ulcerative colitis. Gut 12:632–635, 1971

    Google Scholar 

  150. Lemon FR, Walden RT, Woods RW: Cancer of the lung and mouth in Seventh-Day Adventists: preliminary report on a population study. Cancer 17:486–497, 1964

    Google Scholar 

  151. Hollinshead AC, McWright CG, Alford TC, Glew DH, Gold P, Herberman RB: Separation of skin reactive intestinal cancer antigen from the carcinoembryonic antigen of Gold. Science 177:887–889, 1972

    Google Scholar 

  152. Bull DM, Leiback JR, Williams MA, Helms RA: Immunity to colon cancer assessed by antigen-induced inhibition of mixed mononuclear cell migration. Science 181:957–959, 1973

    Google Scholar 

  153. Hellström I, Sjögren HO, Warner G, Hellström HE: Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms. Int J Cancer 7:226–237, 1971

    Google Scholar 

  154. Penn I, Starzl TE: Immunosuppression and cancer. Transplant Proc 5:943–947, 1973

    Google Scholar 

  155. Patterson JF, Norton RA, Schwartz RS: Azathioprine treatment of ulcerative colitis, granulomatous colitis and regional enteritis. Am J Dig Dis 16:327–332, 1971

    Google Scholar 

  156. Katz S, Sherlock P, Winawer SJ: Rectocolonic exfoliative cytology: a new approach. Am J Dig Dis ns 17:1109–1116, 1972

    Google Scholar 

  157. Morson BC, Pang LSC: Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut 8:423–434, 1967

    Google Scholar 

  158. Lewis B, Morson BC, February AW, Jones JH, Misiewicz JJ: Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change. Gut 12:16–19, 1971

    Google Scholar 

  159. Streifler C, Schnitzer N, Harell A: A rare isoenzyme of alkaline phosphatase in 4 patients with ulcerative colitis. Clin Chim Acta 38:244–246, 1972

    Google Scholar 

  160. Muir GG, Valteris G: Vaginal fluid enzyme patterns in benign and malignant lesions of the female genital tract. J Clin Pathol 22:593–597, 1969

    Google Scholar 

  161. Kim YS, Plaut AG: β-Glucuronidase studies in gastric secretions from patients with gastric cancer. Gastroenterology 49:50–57, 1965

    Google Scholar 

  162. Danovitch SH, Gallucci A, Shora W: Colonic mucosal lysosomal enzyme activities in ulcerative colitis. Am J Dig Dis ns 17:977–992, 1972

    Google Scholar 

  163. Lesher T, Dilwari JB, Hawley PR: Comparison between collagenase activity in rectal biopsies and plasma carcinoembryonic antigen (CEA) levels in patients with carcinoma of the colon and rectum (abstract). Gut 14:819, 1973

    Google Scholar 

  164. Wattenberg LW: A histochemical study of five oxidative enzymes in carcinoma of the large intestine in man. Am J Pathol 35:113–137, 1959

    Google Scholar 

  165. Lipkin M: Proliferation and differentiation of gastrointestinal cells. Physiol Rev 53:891–915, 1973

    Google Scholar 

  166. Deschner EE, Long FC, Katz S: Autoradiographic method for an expanded assessment of colonic cytology. Acta Cytol 17:435–438, 1973

    Google Scholar 

  167. Eastwood GL, Trier JS: Epithelial cell renewal in cultured rectal biopsies in ulcerative colitis. Gastroenterology 64:383–390, 1973

    Google Scholar 

  168. Shorter RG, Spencer RJ, Hallenbeck GA: Kinetic studies of the epithelial cells of the rectal mucosa in normal subjects and patients with ulcerative colitis. Gut 7:593–596, 1966

    Google Scholar 

  169. Mukerjee D, Burdette WJ: Transformation of fibroblasts from patients with colonic cancer by oncogenic virusesin vitro. Carcinoma of the Colon and Antecedent Epithelium WJ Burdette (ed.). Springfield, Illinois, Charles C Thomas, 1970, pp 314–318

    Google Scholar 

  170. Dykes PW, King J: Carcinoembryonic antigen (CEA). Gut 13:1000–1013, 1972

    Google Scholar 

  171. Rule AH, Goleski-Reilly C, Sachar DB, Vandevoorde J, Janowitz HD: Circulating carcinoembryonic antigen (CEA): relationship to clinical status of patients with inflammatory bowel disease. Gut 14:880–884, 1973

    Google Scholar 

  172. Booth SN, King JPG, Leonard JC, Dykes PW: Serum carcinoembryonic antigen in clinical disorders. Gut 14:794–799, 1973

    Google Scholar 

  173. Hall RR, Laurence DJR, Darcy D, Stevens U, James R, Roberts S, Neville AM: Carcinoembryonic antigen in the urine of patients with urothelial carcinoma. Br Med J 3:609–611, 1972

    Google Scholar 

  174. Freed DLG, Taylor G: Carcinoembryonic antigen in faeces. Br Med J 1:85–87, 1972

    Google Scholar 

  175. Winawer SJ, Fleisher M, Melamed M, Sherlock P, Deschner E, Schwartz M: Cytological, immunological (CEA), and isotope labeling studies based on gastrointestinal endoscopic lavage (abstract). Gastroenterology 66:800, 1974

    Google Scholar 

  176. Sherlock P: Genetics and gastrointestinal disease (comment). Gastroenterology 53:675–677, 1967

    Google Scholar 

  177. Lynch HT: Hereditary factors in carcinoma. Recent Results Cancer Res 12:125–142, 1967

    Google Scholar 

  178. Enterline HT, Arvan DA: Chromosome constitution of adenoma and adenocarcinoma of the colon. Cancer 20:1746–1759, 1967

    Google Scholar 

  179. Xavier RG, Prolla JC, Bemvenuti GA, Kirsner JB: Further tissue cytogenetic studies in inflammatory bowel disease (abstract). Gastroenterology 64:875, 1973

    Google Scholar 

  180. Nelson RS: The detection of malignant neoplasia of the gastrointestinal tract by the use of radioactive phosphorus (P32) and a miniature Geiger tube. Gastrointest Endose 15:18–23, 1968

    Google Scholar 

  181. Nash AG, Dance DR, McCready VR, Griffiths JD: Uptake of gallium-67 in colonic and rectal tumours. Br Med J 3:508–510, 1972

    Google Scholar 

  182. Goldenberg DM, Preston DF, Primus FJ, Hansen HJ: Photoscan localization of GW-39 tumors in hamsters using radiolabeled anticarcinoembryonic antigen immunoglobulin G. Cancer Res 34:1–9, 1974

    Google Scholar 

  183. Berk JE: Fluorescence techniques in the diagnosis of malignant lesions of the gastrointestinal tract. Gastrointest Endosc 14:102–105, 1967

    Google Scholar 

  184. Yardley JH, Keren DF: “Precancer” lesions in ulcerative colitis: a retrospective study of rectal biopsy and colectomy specimens. Cancer 34 Suppl:835–844, 1974

    Google Scholar 

  185. Lipkin M: Proliferation and differentiation of normal and neoplastic cells in the colon of man. Cancer 28:38–40, 1971

    Google Scholar 

  186. Truelove SC, Witts LJ: Cortisone in ulcerative colitis: preliminary report on a therapeutic trial. Br Med J 2:375–378, 1954

    Google Scholar 

  187. Truelove SC, Witts LJ: Cortisone and corticotrophin in ulcerative colitis. Br Med J 1:387–394, 1959

    Google Scholar 

  188. Baron JH, Connell AM, Kanaghinis TG, Lennard-Jones JE, Jones FA: Out-patient treatment of ulcerative colitis: comparison between three doses of oral prednisone. Br Med J 2:441–443, 1962

    Google Scholar 

  189. Truelove SC: Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium: a report on a controlled therapeutic trial. Br Med J 2:1072–1077, 1958

    Google Scholar 

  190. Dick AP, Grayson MJ, Carpenter RG, Petrie A: Controlled trial of sulphasalazine in the treatment of ulcerative colitis. Gut 5:437–442, 1964

    Google Scholar 

  191. Rosenberg JL, Wall AJ, Settles RH, Binder HJ, Levin B, Kirsner JB: A controlled trial of azathioprine in the treatment of chronic ulcerative colitis (abstract). Gastroenterology 64:793, 1973

    Google Scholar 

  192. Lennard-Jones JE, Baron JH, Connell AM, Jones FA. A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis. Gut 3:207–210, 1962

    Google Scholar 

  193. Heatley RV, Calcraft BJ, Rhodes J, Owen E, Evans B: Treatment of chronic proctitis with disodium cromoglycate (abstract). Gut 15:829, 1974

    Google Scholar 

  194. Lennard-Jones JE, Misiewicz JJ, Connell AM, Baron JH, Jones FA: Prednisone as maintenance treatment for ulcerative colitis in remission. Lancet 1:188–189, 1965

    Google Scholar 

  195. Misiewicz JJ, Lennard-Jones JE, Connell AM, Baron JH, Jones FA: Controlled trail of sulphasalazine in maintenance therapy for ulcerative colitis. Lancet 1:185–188, 1965

    Google Scholar 

  196. Riis P, Anthonisen P, Wulff HR, Folkenborg O, Bonnevie O, Binder V: The prophylactic effect of salazosulphapyridine in ulcerative colitis during long-term treatment: a double-blind trial on patients asymptomatic for one year. Scand J Gastroenterol 8:71–74, 1973

    Google Scholar 

  197. Dissanayake AS, Truelove SC: A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphasalazine (Salazopyrin). Gut 14:923–926, 1973

    Google Scholar 

  198. Jewell DP, Truelove SC: Azathioprine in ulcerative colitis: an interim report on a controlled therapeutic trial. Br Med J 1:709–712, 1972

    Google Scholar 

  199. Rhodes J, Bainton D, Beck P, Campbell H: Controlled trial of azathioprine in Crohn's disease. Lancet 2:1273–1276, 1971

    Google Scholar 

  200. Anthonisen P, Barany F, Folkenborg O, Holtz A, Jarnum S, Kristensen M, Riis P, Walan A, Worning H: The clinical effect of salazosulphapyridine (Salazopyrin®) in Crohn's disease: a controlled double-blind study. Scand J Gastroenterol 9:549–554, 1974

    Google Scholar 

  201. Klein M, Binder HJ, Mitchell M, Aaronson R, Spiro H: Treatment of Crohn's disease with azathioprine: a controlled evaluation. Gastroenterology 66:916–922, 1974

    Google Scholar 

  202. Willoughby JMT, Kumar PJ, Beckett J, Dawson AM: Controlled trial of azathioprine in Crohn's disease. Lancet 2:944–947, 1971

    Google Scholar 

  203. Watson WC, Bukowsky M: Azathioprine in management of Crohn's disease: a randomized cross-over study (abstract). Gastroenterology 66:796, 1974

    Google Scholar 

  204. Levin B, Rosenberg J, Wall A, Settles R, Kirsner J: A controlled-trial of azathioprine in the treatment of Crohn's disease (abstract). Clin Res 21:868, 1973

    Google Scholar 

  205. Lionel NDW, Herxheimer A: Assessing reports of therapeutic trials. Br Med J 3:637–640, 1970

    Google Scholar 

  206. Glotzer DJ, Gardner RC, Goldman H, Hinrichs HR, Rosen H, Zetzel L: Comparative features and course of ulcerative and granulomatous colitis. N Engl J Med 282:582–587, 1970

    Google Scholar 

  207. Korelitz BI, Present DH, Alpert LI, Marshak PH, Janowitz HD: Recurrent regional ileitis after ileostomy and colectomy for granulomatous colitis. N Engl J Med 287:110–115, 1972

    Google Scholar 

  208. Glotzer DJ: Crohn's disease of the colon-homogeneous or diverse entity? (Editorial.) Gastroenterology 64:1185–1187, 1973

    Google Scholar 

  209. Korelitz BI, Janowitz HD: Controversy on recurrent ileitis after ileostomy: background and speculation (editorial). Gastroenterology 65:498–501, 1973

    Google Scholar 

  210. Nelson JA, Margulis AR, Goldberg HI, Lawson TL: Granulomatous colitis: significance of involvement of the terminal ileum. Gastroenterology 64:1071–1076, 1973

    Google Scholar 

  211. Ritchie JK, Lockhart-Mummery HE: Nonrestorative surgery in the treatment of Crohn's disease of the large bowel. Gut 14:263–269, 1973

    Google Scholar 

  212. Nugent FW, Veidenheimer MC, Meissner WA, Haggitt RC: Prognosis after colonic resection for Crohn's disease of the colon. Gastroenterology 65:398–402, 1973

    Google Scholar 

  213. Kirsner JB: Problems in the differentiation of ulcerative colitis and Crohn's disease of the colon: the need for repeated diagnostic evaluation (editorial). Gastroenterology 68:187–191, 1975

    Google Scholar 

  214. Schachter H, Kirsner JB: Definitions of inflammatory bowel disease of unknown etiology. Gastroenterology 68:591–600, 1975

    Google Scholar 

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Author notes

  1. David A. E. Shephard MD, FRCP(C)

    Present address: Canadian Medical Association, Box 8650, K1G 0G8, Ottawa, Ontario, Canada

Authors and Affiliations

  1. Department of Pathology and Anatomy and Division of Gastroenterology and Internal Medicine the Section of Publications, Mayo Clinic and Mayo Foundation, 55901, Rochester, Minnesota

    Roy G. Shorter MD, FACP &  David A. E. Shephard MD, FRCP(C)

  2. Section of Publications, Mayo Clinic and Mayo Foundation, 55901, Rochester, Minnesota

    Roy G. Shorter MD, FACP &  David A. E. Shephard MD, FRCP(C)

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  1. Roy G. Shorter MD, FACP
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Held at the Houston Oaks Hotel, Houston, Texas, March 25, 26, and 27, 1974.

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Shorter, R.G., Shephard, D.A.E. Frontiers in inflammatory bowel disease. Digest Dis Sci 20, 639–670 (1975). https://doi.org/10.1007/BF01071174

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