Abstract
Beside the rare cases of translocation mongolism, Down syndrom is caused by meiotic malsegregation of chromosomes No. 21. The meiotic error can take place in both sexes and was found twice as frequently in the female as in the male. The same 2∶1 ratio was found concerning nondisjunction in the first and in the second meiotic division. The rate of meiotic errors, which occur at random, is largely dependent on age; this tendency is more pronounced in oogenesis than in spermatogenesis. The results of prenatal chromosomal diagnosis indicate that the recurrence risk of trisomy 21 is not above the age-dependent average.
Similar content being viewed by others
References
Back, E., Zang, K.D.: Humangenetik8, 47 (1969)
Boue, A., Boue, J., in: Physiology and Genetics of Reproduction, B, p. 317 (Coutinho, E.M., Fuchs, F., eds.). New York-London: Plenum Press 1974
Cannings, C., Cannings, M.R.: Nature218, 481 (1968)
Carter, C.O., Evans, K.A.: Lancet1961-II, 785
Caspersson, T., Zech, L., Johansson, C.: Exp. Cell Res.60, 315 (1970)
Caspersson, T., et al.: Chromosoma30, 215 (1970)
Caspersson, T., Lomakka, G., Zech, L.: Hereditas67, 89 (1971)
Collmann, R.D., Stoller, A.: Am. J. Publ. Hlth.52, 813 (1962)
Cooke, P., Curtis, D.J.: Humangenetik23, 279 (1974)
Curtis, D.J.: ibid.22, 17 (1973)
Erickson, J.D.: Am. J. Hum. Genet.31, 489 (1979)
Ferguson-Smith, M.A., et al.: Cytogenetics1, 325 (1963)
German, J.L.: Nature217, 516 (1968)
Henderson, S.A., Edwards, R.G.: ibid.218, 22 (1968)
14. Informationsblatt der Deutschen Forschungsgemeinschaft über „Pränatale Diagnostik genetisch bedingter Defekte” (Murken, J.D., Stengel-Rutkowski, S., Hrsg.). München 1979
James, W.H.: Nature219, 279 (1968)
Jenkins, R.L.: Am. J. Dis. Childh.45, 506 (1933)
Koch, G.: Down-Syndrom. Bihliographica genetica medica des Instituts für Humangenetik der Universität Erlangen No. 1, 1973
Langdon-Down, J.: Clin. Lect. Rep., London Hosp.3, 259 (1866)
Lejeune, J., Gautier, M., Turpin, R.: C.R. Acad. Sci. (Paris)248, 1721 (1959)
Lejeune, J., Turpin, R., Gautier, M.: Ann. Genet.1, 41 (1959)
Mattei, J.F., et al.: Humangenetik25, 29 (1974)
Matsunaga, E., Maruyama, T.: Nature221, 642 (1969)
Mikkelsen, M., Stene, J.: Hum. Hered.20, 457 (1970)
Mikkelsen, M.: Humangenetik12, 1 (1971)
Passarge, E., in: Methoden in der medizinischen Cytogenetik (Schwarzacher, H.G., Wolf, U., Hrsg.). Berlin-Heidelberg-New York: Springer 1970
Penrose, L.S.: J. Genet.27, 219 (1933)
Penrose, L.S.: J. Ment. Sci.85, 1141 (1939)
Penrose, L.S.: ibid.97, 783 (1951)
Penrose, L.S.: Lancet1954-I, 505
Polani, P.E., et al.: ibid.1960-I, 721
Race, R.R., Sanger, R.: Brit. Med. Bull.25, 99 (1969)
Rett, A., Schnedl, W., Wagenbichler, P.: Wien. med. Wschr.127, 510 (1977)
Rosenkranz, W., Holzer, S.: Humangenetik16, 147 (1972)
Seguin, E.: Le traitment moral, l'hygiene et l'education des idiots. Paris: Bailliere 1846
Schnedl, W.: Humangenetik12, 59 (1971)
Schnedl, W.: Z. Rechtsmed.74, 17 (1974)
Taysi, K.: Clin. Genet.8, 319 (1975)
Tijo, J.H., Levan, A.: Hereditas (Lund)42, 1 (1956)
Wagenbichler, P., Golob, E.: Gynäk. Rdsch.15, 225 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wagenbichler, P. Zur Ätiologie des Mongolismus. Naturwissenschaften 68, 76–81 (1981). https://doi.org/10.1007/BF01047225
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01047225