Abstract
The properties and reactivities of 4-hydroxy- and 2,4-dihydroxy-5-(β-hydroxyethyl)pyrimidines and of the products of their transformations have been studied. 4-Chloro- and 2,4-dichloro-5-(β-chloroethyl)pyrimidines have been obtained. A number of 4-alkyl(aryl)amino-5-(β-chloroethyl)pyrimidines have been synthesized, and they have been converted into derivatives of 5,6-dihydropyrrolo[2,3-d]pyrimidine.
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References
K. A. Chkhikvadze and O. Yu. Magidson, ZhOKh,34, 2577, 1964.
R. A. West, J. Org. Chem.,26, 4959, 1961.
A. Schrage and H. Hitchings, J. Org. Chem.,16, 1153, 1951.
R. F. Evans and J. S. Shannon, J. Chem. Soc., 1406, 1965.
K. Kitani and H. Sodeoka, J. Chem. Soc. Japan,74, 624, 1953; C. A.,48, 13393, 1954.
H. G. Koppel, R. H. Springer, R. K. Robins, and C. C. Cheng, J. Org. Chem.,27, 181, 1962; H. Ballweg, Ann., 673, 151, 1964.
C. K. Banks, J. Am. Chem. Soc.,66, 1127, 1944; A. Magiolo and A. P. Phillips, J. Org. Chem.,16, 376, 1951.
L. N. Yakhontov and M. V. Rubtsov, ZhOKh,30, 3300, 1960.
Y. Mizuno, M. Ikehara, K. Watanabe, and S. Suzaki, Chem. Pharm. Bull.,11, 1091, 1963; C. Taylor and R. Hendess, J. Am. Chem. Soc.,86, 95, 1964; P. H. Hammer, J. Pharm. Sci.,54, 1826, 1965.
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For part I, see [1].
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Chkhikvadze, K.A., Koretskaya, N.I., Rodnyanskaya, N.S. et al. 5-Substituted pyrimidine derivatives. Chem Heterocycl Compd 5, 108–111 (1969). https://doi.org/10.1007/BF01031784
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DOI: https://doi.org/10.1007/BF01031784