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Einfluβ von zytostatischer Langzeitchemotherapie auf hämatopoetische Stammzellen

The influence of long term cytotoxic chemotherapy on hematopoietic stem cells

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Summary

CFU-C and diffusion chamber studies were performed in patients with teratocarcinoma, who underwent long term chemotherapy. No significant decline of bone marrow CFU-C or diffusion chamber cell recovery was found during twelve months of cytotoxic treatment. In contrast to the results in these patients the CFU-C-content of the remission marrow in leukemic patients showed a significant decrease in relation to the duration of remission and chemotherapy.

Zusammenfassung

Knochenmarksproben von Patienten mit Teratokarzinom unter zytostatischer Langzeitchemotherapie wurden mit der Agarkultur (CFU-C) und in der Diffusionskammer (DK) untersucht. Während einer zwölfmonatigen Beobachtungsperiode zeigte sich keine signifikante Abnahme der CFU-C-Zahl oder der DK-Proliferationskapazität. Im Unterschied hierzu wurde bei Patienten mit akuter Leukämie in Vollremission ein signifikanter Abfall der CFU-C im Knochenmark im Verhältnis zur Dauer der Remission und der zytostatischen Behandlung gefunden.

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Literatur

  1. Marsh, J.C.: The effects of cancer chemotherapeutic agents on normal hematopoietic precursor cells: A review. Cancer Res.36, 1853–1882 (1976)

    CAS  PubMed  Google Scholar 

  2. Cudkowicz, G., Upton, A.C., Shearer, G.M.: Lymphocyte content and proliferative capacity of serially transplanted mouse bone marrow. Nature201, 165–167 (1964)

    Article  CAS  PubMed  Google Scholar 

  3. Botnick, L.E., Hannon, E.G., Hellman, S.: Multisystem stem cell failure after apparent recovery from alkylating agents. Cancer Res.38, 1942–1947 (1978)

    CAS  PubMed  Google Scholar 

  4. Pike, B.L., Robinson, W.A.: Human bone marrow culture in agar gel. J. Cell. Physiol.76, 77 (1970)

    Article  CAS  PubMed  Google Scholar 

  5. Cronkite, E.P., Carsten, A.L., Chikkappa, G., Laissue, J.A., Öhl, S.: Culture of normal and leukemic cells in diffusion chambers. Advanc. Biosci.14, 273 (1975)

    Google Scholar 

  6. Schaefer, U.W., Nowrousian, M.R., Öhl, S., Schmidt, C.G.: Cryopreservation of bone marrow. In: Cell-separation and cryobiology. Selected papers of an international symposium in Vienna, November 9–12, 1977. Rainer, H., Borberg, H., Mishler, J.M., Schaefer, U.W. (eds.), pp. 243–254. Stuttgart, New York: Schattauer 1978.

    Google Scholar 

  7. Nowrousian, M.R., Schaefer, U.W., Öhl, S., Boecker, W.R., Scheulen, M.E., Schilcher, R.B., Schmidt, C.G.: Effects of long term chemotherapy on the stem cell potential of human bone marrow, (in preparation)

  8. Hossfeld, D.K., Faltermaier, M.T., Schmidt, C.G.: Therapieergebnisse der akuten nichtlymphoblastischen Leukämie bei Erwachsenen. Verh. Dtsch. Ges. Inn. Med.84, 155–156 (1978)

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Westdeutsches Tumorzentrum, Innere Klinik und Poliklinik (Tumorforschung), Universitätsklinikum der GHS, Hufelandstra\e 55, D-4300, Essen 1, Bundesrepublik Deutschland

    M. R. Nowrousian, U. W. Schaefer, S. Öhl, W. R. Boecker, M. E. Scheulen, R. B. Schilcher & C. G. Schmidt

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  1. M. R. Nowrousian
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  2. U. W. Schaefer
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  3. S. Öhl
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  4. W. R. Boecker
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  5. M. E. Scheulen
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  6. R. B. Schilcher
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  7. C. G. Schmidt
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Additional information

Unterstützt vom Landesamt für Forschung in Düsseldorf und Bundesministerium für Jugend, Familie und Gesundheit in Bonn

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Nowrousian, M.R., Schaefer, U.W., Öhl, S. et al. Einfluβ von zytostatischer Langzeitchemotherapie auf hämatopoetische Stammzellen. Blut 38, 479–482 (1979). https://doi.org/10.1007/BF01013509

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  • DOI: https://doi.org/10.1007/BF01013509

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