Summary
The relative bioavailability and pharmacokinetics of two orally administered aqueous suspensions of noscapine hydrogen embonate were compared with those of noscapine hydrochloride solution. Noscapine hydrochloride showed faster absorption and gave a higher peak concentration than the embonate. The average bioavailability of the embonates was 71% of that of the noscapine solution (p<0.05). No significant difference was observed when the embonate was administered with water, polyvidone and flavouring agents.
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References
Haikala V, Marvola M, Sothmann A (1986) Formulation studies of a new noscapine embonate preparation. Drug Devel Ind Pharm (in press)
Haikala V (1985) New sensitive method to determine noscapine in serum by reversed-phase liquid chromatography. J Chromatogr 337: 429–443
Vedsö S (1961) Absorption and excretion of noscapine. Acta Pharmacol Toxicol 18: 157–164
Nayak KP, Brochmann-Hanssen E, Leong Way E (1965) Biological disposition of noscapine. Pharm Sci 54: 191–194
Gibaldi M, Weiner N (1966) Biphasic elimination of noscapine. J Pharm Sci 55: 761–771
Dahström B, Mellstrand T, Löfdahl C-G, Johansson M (1982) Pharmacokinetic properties of noscapine. Eur J Clin Pharmacol 22: 532–539
Johansson M, Eksborg S, Arbin A (1983) Determination of noscapine in plasma by liquid chromatography. J Chromatogr 275: 355–366
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Haikala, V., Sothmann, A. & Marvola, M. Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride. Eur J Clin Pharmacol 31, 367–369 (1986). https://doi.org/10.1007/BF00981140
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DOI: https://doi.org/10.1007/BF00981140