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The effect of medial forebrain bundle lesion on thyrotropin secretion in the rat

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Abstract

The medial forebrain bundle (MFB) was partially lesioned with 6-hydroxydopamine (6-OHDA) in order to investigate the effect of deficient central noradrenergic regulation on thyrotropin (TSH) secretion in the rat. 6-OHDA injection into the MFB significantly reduced the noradrenaline (NA), dopamine (DA) and serotonin (5-HT) content of the whole hypothalamus. NA and 5-HT concentrations were also significantly decreased in the paraventricular nucleus (PVN). The MFB lesion did not affect the clonidine (250 μg/kg, i.p.) induced stimulation of TSH release or the isoproterenol (1 mg/kg i.p.) induced decrease in TSH levels. Thyrotropin releasing hormone (TRH, 5 μg/kg i.v.) caused a similar significant stimulation of TSH secretion in lesioned and non-lesioned rats. The present results do not support the hypothesis that the blunted TSH response to TRH observed in depressed patients results from a deficiency in noradrenergic neurotransmission.

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Authors and Affiliations

  1. MRC Research Unit for the Neurochemistry of Mental Diseases, Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, P.O. Box 19113, 7505, Tygerberg, (R.S.A.)

    Abdullah Jaffer, William M. U. Daniels, Vivienne A. Russell & Joshua J. F. Taljaard

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  1. Abdullah Jaffer
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  2. William M. U. Daniels
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  3. Vivienne A. Russell
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  4. Joshua J. F. Taljaard
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Jaffer, A., Daniels, W.M.U., Russell, V.A. et al. The effect of medial forebrain bundle lesion on thyrotropin secretion in the rat. Neurochem Res 16, 577–581 (1991). https://doi.org/10.1007/BF00974877

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