Abstract
Effects of dopamine (DA) were examined on the intracellularly recorded potential from horizontal cells in the fish (Eugerres plumieri) retina. DA (100 μM in the perfusate) augmented the center S potential in a response to a spot illumination and attenuated the surrounding S potential to an annular light by approximately 40%. These reciprocal changes in the S potentials were associated with a slight depolarization (2.5 mV) of the horizontal cell, and were reversible in 10–15 min. The results indicate that DA at this concentration does not affect directly the synaptic transmission from photoreceptors to horizontal cells, while it appears to interfere selectively with the lateral propagation of an S potential. The effects of DA observed may represent an aspect of function of DA-containing interplexiform cells in the retina.
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Dowling, J. E., andEhinger, B. 1978. The interplexiform cell system I. Synapses of the dopaminergic neurons of the goldfish retina. Proc. R. Soc. London, Ser. B 201:7–26.
Dowling, J. E., Ehinger, B., andHedden, W. L. 1976. The interplexiform cell: A new type of retinal neuron. Invest. Ophthalmol. 15:916–926.
Drujan, B. D., andSvaetichin, G. 1972. Characterization of different classes of isolated retinal cells. Vision Res 12:1777–1784.
Drujan, B. D., Svaetichin, G., Negishi, K., andBrzin, M. 1971. Biochemical and electrophysiological studies on the functional contacts of the horizontal cells. First Eur. Cong., Baden near Vienna VII B/4:89–96.
Guerrero, R.. 1978. Dependencia ionica de los potenciales de celulas horizontales en la retina deEugerres plumieri. Master's degree thesis, Centro de Estudios Avanzados, IVIC, Caracas, Venezuela.
Hedden, W. L., andDowling, J. E. 1978. The interplexiform cell system II. Effects of dopamine on goldfish retinal neurons. Proc. R. Soc. London, Ser. B. 201:27–55.
Kaneko, A. 1971. Electrical connections between horizontal cells in the dogfish retina. J. Physiol. 213:95–105.
Laufer, M., andMillán, E. 1970. Spectral analysis of L-type S-potentials and their relation to photopigment absorption in a fish (Eugerres plumieri) retina. Vision Res. 10:237–257.
Laufer, M., andNegishi, K. 1978. Enhancement of hyperpolarizing S-potenials by surround illumination in a teleost retina. Vision Res. (in press).
Naka, K.-I., andRushton, W. A. H. 1967. The generation and spread of S-potentials in the fish (Cyprinidae). J. Physiol. 192:437–461.
Negishi, K. 1971. Reduction and enhancement of S-potential, observed with two simultaneous light stimuli in the isolated fish retina. Vision Res. Suppl. 3:65–76.
Negishi, K., Kato, S., Teranishi, T., andLaufer, M. 1978. Dual actions of some amino acids on spike discharges in the carp retina. Brain Res. 148:67–84.
Negishi, K., Kato, S., Teranishi, T., andLaufer, M. 1978. An electrophysiological study on the cholinergic system in the carp retina. Brain Res. 148:85–93.
Negishi, K., Kato, S., andSugawara, K. 1978. Effects of locally applied chemicals on transretinal potential and horizontal cells in the isolated carp retina I. Amino acids. Pflügers Arch. (in press),
Negishi, K., Kato, S., andSugawara, K. 1978. Effects of locally applied chemicals on transeetinal potential and horizontal cells in the isolated carp retina, II. Calciumchelator. Pflügers Arch. (in press).
Sugawara, K., andNegishi, K. 1973. Effects of some amino acids on light-induced responses in the isolated carp retina. Vision Res. 13:2479–2489.
Svaetichin, G. 1967. Celulas horizontales y amacrinas de la retina: Propiedades y mecanismos de control sobre las bipolares y ganglionares. Acta Cient. Venez. Supl. 3:254–276.
Svaetichin, G., Negishi, K., andFatehchand, R. 1965. Cellular mechanisms of the Young-Hering visual systems. Pages 178–203,in De Reuck, A. V. S., andKnight, J. (eds.), Ciba Foundation Symposium on Colour Vision., Churchill, London.
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Negishi, K., Drujan, B.D. Reciprocal changes in center and surrounding S potentials of fish retina in response to dopamine. Neurochem Res 4, 313–318 (1979). https://doi.org/10.1007/BF00963801
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DOI: https://doi.org/10.1007/BF00963801