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Arylamides of substituted thioacetic acids

IV. Reaction of arylamides of monoacetylthioacetic acid with nucleophilic reagents

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of arylamides of monoacetylthioacetic acid with arylhydrazines and hydrazine hydrate has given, respectively, 1-aryl-5-arylamino-3-methylpyrazoles and 5-arylamino-3-methylpyrazoles, the structures of which have been confirmed by independent synthesis and by their IR and UV spectra. It has been shown that, on reacting with arylamides of monoacetylthioacetic acid, nitrogen bases attack first the carbonyl and then the thiocarbonyl group of these compounds, forming substituted pyrazoles.

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Authors and Affiliations

  1. Institute of Organic Chemistry AS UkrSSR, Kiev

    A. N. Borisevich & P. S. Pel'kis

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  1. A. N. Borisevich
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  2. P. S. Pel'kis
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Additional information

For part III, see [3].

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Borisevich, A.N., Pel'kis, P.S. Arylamides of substituted thioacetic acids. Chem Heterocycl Compd 5, 237–239 (1969). https://doi.org/10.1007/BF00943927

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  • DOI: https://doi.org/10.1007/BF00943927

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