Conclusions
-
1.
The combined dehydration of N-acylated α-amino acids with primary aliphatic amines in the presence of POC13 results in the formation of bisoxazolyl-N-alkylamines, dihydropyrazines, tetrahydropyrazines with alkylamino, alkylimino, or keto substituents.
-
2.
The yields of the oxazolylalkylamines and hydropyrazines depend on the relative amounts of the reactants and total from 60 to 70%.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
G. Ya. Kondrat'eva, M. A. Aitzhanova, V. S. Bogdanov, and Z. N. Ivanova, Izv. Akad. Nauk SSSR, Ser. Khim., 894 (1978).
D. Clerin and Y.-P. Fleury, Bull. Soc. Chim. France, 3127 (1973).
Author information
Authors and Affiliations
Additional information
Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1111–1118, May, 1978.
Rights and permissions
About this article
Cite this article
Kondrat'eva, G.Y., Aitzhanova, M.A., Bogdanov, V.S. et al. Reaction of N-acylated α-amino acids with primary amines. Russ Chem Bull 27, 963–969 (1978). https://doi.org/10.1007/BF00929001
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00929001