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Changes in hematopoiesis in rats after destruction of the posterior hypothalamic nuclei

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of bilateral electrical coagulation of the posterior (nuclei of the mammillary body and the posterior hypothalamic nucleus) part of the hypothalamus on hematopoiesis was studied in rats. Inhibition of erythropoiesis was observed for 28 days after destruction of the nuclei of the posterior hypothalamus: a decrease in proliferative activity and a percentage of erythroid cells in the bone marrow, a decrease in the number of erythrocytes and hematocrit index and an increase in the number of reticulocytes in the peripheral blood. Meanwhile stimulation of granulocytopoiesis was observed: a increase in the proliferative activity and percentage of immature granulocytes in the animals'bone marrow.

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Authors
  1. Z. M. Likhovetskaya
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  2. A. I. L'vovich
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Likhovetskaya, Z.M., L'vovich, A.I. Changes in hematopoiesis in rats after destruction of the posterior hypothalamic nuclei. Bull Exp Biol Med 88, 844–847 (1979). https://doi.org/10.1007/BF00869210

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  • DOI: https://doi.org/10.1007/BF00869210

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