Abstract
The contribution of sympathetic nerves to the hemodynamic effects of unilateral ureteral obstruction (UUO) was investigated in the neonatal guinea pig. The left ureter was partially constricted (or sham-operated) at birth, and sympathetic innervation was inhibited by guanethidine and compared with saline vehicle-treated animals. At 15–20 days of age, blood presure, cardiac output, total vascular resistance (TVR), renal blood flow, and renal vascular resistance (RVR) were determined before and after infusion of enalapril. UUO reduced cardiac output, increased TVR, and increased RVR of the ipsilateral kidney, whereas guanethidine treatment had no additional effects. Enalapril decreased RVR only in obstructed kidneys and not in intact opposite kidneys of animals with UUO. This was not affected by guanethidine administration. In contrast, enalapril decreased RVR only in guanethidine-treated (but not saline-treated) sham-operated guinea pigs. Therefore, UUO increases angiotensin-dependent vascular tone of the ipsilateral kidney independent of renal innervation. However, UUO decreases angiotensin-mediated vascular tone of the contralateral kidney, an effect unmasked by sympathectomy.
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Chevalier RL, Sturgill BC, Jones CE, Kaiser DL (1987) Morphologic correlates of renal growth arrest in neonatal partial ureteral obstruction. Pediatr Res 21:338–346
Gomez RA, Lynch KR, Sturgill BC, Elwood, JP, Chevalier RL, Carey RM, Peach MJ (1989) Distribution of renin mRNA and its protein in the developing kidney. Am J Physiol 257:F850-F858
Gomez R, Pupilli C, Everett A (1991) Molecular and cellular aspects of renin during kidney ontogeny. Pediatr Nephrol 5:80–87
Chevalier RL, Peach MJ (1985) Hemodyamic effects of enalapril on neonatal chronic partial ureteral obstruction. Kidney Int 28:891–898
Pelayo JC, Blantz RC (1984) Analysis of renal denervation in the hydropenic rat: interactions with angiotensis II. Am J Physiol 246:F87-F95
Chevalier RL, Kaiser DL (1984) Chronic partial ureteral obstruction in the neonatal guinea pig. I. Influence of unine-phrectomy on growth and hemodynamics. Pediatr Res 18:1266–1271
Chevalier RL, Jones CE (1986) Contribution of endogenous vasoactive compounds to renal vascular resistance in neonatal chronic partial ureteral obstruction. J Urol 136:532–535
Chevalier RL (1984) chronic partial ureteral obstruction in the neonatal guinea pig. II. Pressure gradients affecting glomerular filtration rate. Pediatr Res 18:1271–1277
Chevalier RL, Gomez RA (1989) Response of the renin-angiotensin system to relief of neonatal ureteral obstruction. Am J Physiol 255:F1070-F1077
Chevalier RL, Gomez RA, Jones CA (1988) Developmental determinants of recovery after relief of partial ureteral obstruction. Kidney Int 33:775–781
Johnson EM Jr, O'Brien F, Werbitt R (1976) Modification and characterization of the permanent sympathectomy produced by the administration of guanethidine to newborn rats. Eur J Pharmacol 37:45–54
El-Dahr SS, Gomez RA, Gray MS, Peach MJ, Carey RM, Chevalier RL (1991) Renal nerves modulate renin gene expression in the developing rat kidney with ureteral obstruction. J Clin Invest 87:800–810
Sealey JE, Laragh JH (1977) How to do a plasma renin assay. Cardiovasc Med 2:1079–1092
Chevalier RL, Gomez RA, Carey RM, Peach MJ, Linden JM (1988) Renal effects of atrial natriuretic peptide infusion in young and adult rats. Pediatr Res 24:333–337
Wilson DR, Honrath U, Sole MJ (1983) Tissue catecholamines in obstructive nephropathy and acute uremia in the rat. Can J Physiol Pharmacol 61:131–136
Wong PC, Bernard R, Timmermans PBMWM (1992) Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function. Hypertension 19:663–667
Wong PC, Hart SD, Timmermans P (1991) Effect of angiotensin II antagonism on canine renal sympathetic nerve function. Hypertension 17:1127–1134
Tucker BJ, Mundy CA, Maciejewski AR, Printz MP, Ziegler MG, Pelayo JC, Blantz RC (1986) Changes in glomerular hemodynamic response to angiotensin II after subscute renal denervation in rats. J Clin Invest 78:680–688
Chevalier RL, Gomez RA (1988) Response of the renin-angiotensin system to relief of neonatal ureteral obstruction. Am J Physiol 255:F1070-F1077
Chevalier RL, Thornhill BA (1995) Ureteral obstruction in the neonatal rat. Renal nerves modulate hemodynamic effects Peditit Nephrol (in press)
Torikai S (1988) A renorenal suppression in response to atrial natriuretic peptide in the unilateral ischaemic rat. Clin Sci 74:519–525
El-Dahr SS, Gomez RA, Gray MS, Peach MJ, Carey RM, Chevalier RL (1990) In situ localization of renin and its mRNA la neonatal ureteral obstruction. Am J Physiol 258:F854-F862
Harris KPG, Yanagisawa H, Schreiner GF, Klahr S (1991) Evidence for two distinct and functionally important sites of enhanced thromboxame production after bilateral ureteral obstruction in the rat. Clin Sci 81:209–213
Reyes AA, Klahr S (1992) Renal function after release of ureteral obstruction: role of endothelin and the renal artery endothelium. Kidney Int 42:632–638
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Chevalier, R.L., Thornhill, B.A. Ureteral obstruction in the neonatal guinea pig: Interaction of sympathetic nerves and angiotensin. Pediatr Nephrol 9, 441–446 (1995). https://doi.org/10.1007/BF00866723
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DOI: https://doi.org/10.1007/BF00866723