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Proceedings of the American Society of Pediatric Nephrology 1993 Education Symposium, Washington, D. C., 4 May, 1993

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References

  1. International Reflux Study Committee (1981) Medical versus surgical treatment of primary vesicoureteral reflux. Pediatrics 67: 392–400

    Google Scholar 

  2. Olbing H (1987) Vesico-ureteral-renal reflux and the kidney. Pediatr Nephrol 1: 638–646

    PubMed  Google Scholar 

  3. Allen TD, Arant BS Jr, Roberts JA (1992) Commentary: vesicoureteral reflux-1992. J Urol 148: 1758–1760

    PubMed  Google Scholar 

  4. Arant BS Jr (1991) Vesicoureteral reflux and renal injury. Am J Kidney Dis 17: 491–511

    PubMed  Google Scholar 

  5. Birmingham Reflux Study Group (1987) Prospective trial of operative versus non-operative treatment of severe vesicoureteral reflux in children: five years observation. BMJ 295: 237–241

    Google Scholar 

  6. Weiss R, Duckett J, Spitzer A (1992) Results of a randomized clinical trial of medical versus surgical management of infants and children with grades III and IV primary vesicoureteral reflux (United States). J Urol 148: 1667–1673

    PubMed  Google Scholar 

  7. Arant BS Jr (1992) Medical management of mild and moderate vesicoureteral reflux: followup studies of infants and young children. A preliminary report of the southwest pediatric nephrology study group. J Urol 148: 1683–1887

    PubMed  Google Scholar 

  8. Van den Abbeele, Treves ST, Lebowitz RL, et al (1987) Vesicoureteral reflux in asymptomatic siblings of patients with known reflux: radionuclide cystography. Pediatrics 79: 147–153

    PubMed  Google Scholar 

  9. Hutch JA (1961) Theory of maturation of the intravesical ureter. J Urol 86: 534–538

    PubMed  Google Scholar 

  10. Smellie JM, Hodson CJ, Edwards D, et al (1964) Clinical and radiological features of urinary infection in childhood. BMJ 2: 1222–1226

    Google Scholar 

  11. Lebowitz RL, Olbing H, Parkullainen KV, et al (1985) International system of radiographic grading of vesicoureteral reflux. Pediatr Radiol 15: 105–109

    PubMed  Google Scholar 

  12. Mendoza J, Roberts JA (1983) Effects of sterile high pressure vesicoureteral reflux on the monkey. J Urol 130: 602–606

    PubMed  Google Scholar 

  13. Elo J, Tallgren LG, Alfthan O, et al (1983) Character of urinary tract infections and pyelonephritic renal scarring after antireflux surgery. J Urol 129: 343–346

    PubMed  Google Scholar 

  14. Edwards D, Normand ICS, Prescod N, et al (1977) Disappearance of vesicoureteral reflux during long-term prophylaxis of urinary tract infection in children. BMJ 2: 285–288

    PubMed  Google Scholar 

  15. Berger RE, Ansell JS, Shurtleff DB, et al (1981) Vesicoureteral reflux in children with uremia. JAMA 246: 56–59

    PubMed  Google Scholar 

  16. Heptinstall RH, Hodson CJ (1984) Pathology of sterile reflux in the pig. Contrib Nephrol 39: 344–357

    PubMed  Google Scholar 

  17. Ransley PG, Risdon RA (1979) The renal papilla, intrarenal reflux and chronic pyelonephritis. In: Hodson CJ, Kincaid-Smith P (eds) Reflux nephropathy. Masson, New York, pp 126–133

    Google Scholar 

  18. Bernstein J, Arant BS Jr (1992) Morphological characteristics of segmental renal scarring in vesicoureteral reflux. J Urol 148: 1712–1714

    PubMed  Google Scholar 

  19. Ivanyi B, Theones W (1987) Microvascular injury and repair in acute human bacterial pyelonephritis. Virchows Arch [A] 411: 257–265

    Google Scholar 

  20. Nath KA (1992) Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20: 1–17

    PubMed  Google Scholar 

  21. Yee J, Kuncio GS, Neilson EG (1991) Tubulointerstitial injury following glomerulonephritis. Semin Nephrol 11: 361–366

    PubMed  Google Scholar 

  22. Rubin-Kelley VE, Jevnikar AM (1991) Antigen presentation by renal tubular epithelial cells. J Am Soc Nephrol 2: 13–26

    PubMed  Google Scholar 

  23. Jones CL, Eddy AA (1992) Tubulointerstitial nephritis. Pediatr Nephrol 6: 572–586

    PubMed  Google Scholar 

  24. Eddy AA, McCulloch L, Liu E, et al (1991) A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome. Am J Pathol 138: 1111–1123

    PubMed  Google Scholar 

  25. Kees-Foults D, Schreiner GF (1991) A lipid chemotactic factor associated with proteinuria and interstitial nephritis induced by protein overload (abstract). J Am Soc Nephrol 2: 548

    Google Scholar 

  26. Wuthrich RP, Jevnikar AM, Takei F, et al (1990) Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune lupus nephritis. Am J Pathol 136: 441–450

    PubMed  Google Scholar 

  27. Okuda S, Languino LR, Ruoslahti E, et al (1990) Elevated expression of transforming growth factor-b and proteoglycan production in experimental glomerulonephritis. J Clin Invest 86: 453–462

    PubMed  Google Scholar 

  28. Jones CL, Buch S, Post, et al (1992) Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats. Am J Pathol 141: 1381–1396

    PubMed  Google Scholar 

  29. Skinner R, Pearson ADJ, Price L, Coulthard MG, Croft AW (1992) The influence of age on nephrotoxicity following chemotherapy in children. Br J Cancer 66 [Suppl 8]: 530–535

    Google Scholar 

  30. Brock PR, Koliouskas DE, Barratt TM, Yeomans E, Pritchard J (1991) Partial reversibility of cisplatin nephrotoxicity in children. J Pediatr 118: 531–534

    PubMed  Google Scholar 

  31. Koren G, Klein J, MacLeod SM (1988) Dissociation between serum concentrations and nephrotoxicity of aminoglycosides. Life Sci 3: 1817–1823

    Google Scholar 

  32. Jongerjan HTM, Provoost AP, Molemar JC (1989) Potentiated nephrotoxicity of cisplatin when combined with amikacin comparing young and adult animals. Pediatr Nephrol 3: 290–295

    PubMed  Google Scholar 

  33. Shore R, Greenberg M, Geary D, Koren G (1992) Ifosphamide-induced nephrotoxicity in children. Pediatr Nephrol 6: 162–165

    PubMed  Google Scholar 

  34. Kumin GD (1980) Clinical nephrotoxicity of tobramycin and gentamicin. JAMA 244: 1808–1810

    PubMed  Google Scholar 

  35. Bennett WM (1989) Editorial review: mechanisms of aminoglycoside nephrotoxicity. Clin Exp Pharmacol Physiol 16: 1–6

    PubMed  Google Scholar 

  36. Moore RD, Smith CR, Lietman PS (1986) Increased risk of renal dysfunction due to interaction of liver disease and aminoglycosides. Am J Med 80: 1093–1097

    PubMed  Google Scholar 

  37. Laurent G, Toubeau G, Heuson-Stiennon JA, Tulkens P, Maldaugue P (1988) Kidney tissue repair after nephrotoxic injury: biochemical and morphological characterization. CRC Crit Rev Toxicol 19: 147–183

    Google Scholar 

  38. Humes HD (1988) Aminoglycoside nephrotoxicity. Kidney Int 33: 900–911

    PubMed  Google Scholar 

  39. Brasseur R, Laurent G, Ruysschaert JM, Tulkens P (1984) Interactions of aminoglycoside antibiotics with negatively charged lipid layers: biochemical and conformational studies. Biochem Pharmacol 33: 629–637

    PubMed  Google Scholar 

  40. Silverblatt FJ, Kuehn C (1979) Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney Int 15: 335–345

    PubMed  Google Scholar 

  41. Laurent G, Kishore BK, Tulkens PM (1990) Commentary: aminoglycoside-induced renal phospholipidosis and nephrotoxicity. Biochem Pharmacol 40: 2382–2392

    Google Scholar 

  42. Ford DM, Dahl RH, Weng CA, Molitoris BA (1991) Simultaneous apical and basolateral membrane aminoglycoside uptake: quantitation and localization within the endosomal compartment of LLC-PK1 cells (abstract). J Am Soc Nephrol 2: 662

    Google Scholar 

  43. Bennett WM, Mela-Riker LM, Houghton DC, Gilbert DN, Buss WC (1988) Microsomal protein synthesis inhibition: an early manifestation of gentamicin nephrotoxicity. Am J Physiol 255: F265-F269

    PubMed  Google Scholar 

  44. Weinberg JM, Humes HD (1980) Mechanisms of gentamicin-induced dysfunction of renal cortical mitochondria. I. Effects of mitochondrial respiration. Arch Biochem Biophys 205: 222–231

    PubMed  Google Scholar 

  45. Williams PD, Holohan PD, Ross CR (1981) Gentamicin nephrotoxicity. II. Plasma membrane changes. Toxicol Appl Pharmacol 61: 243–251

    PubMed  Google Scholar 

  46. Wedeen RP, Batuman B, Cheeks C, Marquet E, Sobel H (1983) Transport of gentamicin in rat proximal tubule. Lab Invest 48: 212–223

    PubMed  Google Scholar 

  47. Smith CR, Moore RD, Lietman PS (1986) Studies of risk factors for aminoglycoside nephrotoxicity. Am J Kidney Dis 8: 308–313

    PubMed  Google Scholar 

  48. Spiegel DM, Shanley PF, Molitoris BA (1990) Mild ischemia predisposes the S3 segment to gentamicin toxicity. Kidney Int 38: 459–464

    PubMed  Google Scholar 

  49. Humes HD, Sastrasinh M, Weinberg JM (1984) Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity. J Clin Invest 73: 134–147

    PubMed  Google Scholar 

  50. Kishore BK, Kallay Z, Lambricht P, Laurent G, Tulkens P (1990) Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. I. Polyaspartic acid binds gentamicin and displaces it from negatively charged phospholipid layers in vitro. J Pharmacol Exp Ther 255: 867–874

    PubMed  Google Scholar 

  51. Cronin RE, Burton ME, Demain SE (1990) Protective effect of pentoxifilline analogue (HWA-448) but not pentoxifylline against gentamicin nephrotoxicity (abstract). J Am Soc Nephrol 1: 595

    Google Scholar 

  52. Thieme RE, Molitoris BA, Lamp CA, Ford DM (1972) The protective mechanism of the pentoxifylline analogue HWA-448 in gentamicin nephrotoxicity (abstract). J Am Soc Nephrol 3: 731

    Google Scholar 

  53. Brajtburg J, Powderly W, Medoff G (1990) Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother 34: 183–188

    PubMed  Google Scholar 

  54. Sabra R, Takahaski R, Branch A, Badr K (1990) Mechanism of amphotericin B-induced reduction of glomerular filtration rate. J Pharmacol Exp Ther 253: 34–37

    PubMed  Google Scholar 

  55. Sawaya B, Weilhprecht H, Campbell W, Briggs J, Schnermann J (1991) Direct vasoconstriction as a possible cause for amphotericin B-induced nephrotoxicity in rats. J Clin Invest 87: 2097–2107

    PubMed  Google Scholar 

  56. Tolins J, Raij L (1988) Adverse effect of amphotericin B administration on renal hemodynamics in the rat. J Pharmacol Exp Ther 245: 594–599

    PubMed  Google Scholar 

  57. Heyman S, Clark B, Kaiser N, Epstein F, Brezis M (1992) Effect of amphotericin B on endothelin release. J Antimicrob Chemother 29: 69–77

    PubMed  Google Scholar 

  58. Hardie W, Ebert J, Frazer M, Badr K (1983) The effect of thromboxane receptor antagonism on amphotericin B-induced renal vasoconstriction in the rat. Prostaglandins 45: 47–56

    Google Scholar 

  59. Bianco J, Almgren J, Kern D, Signer J (1991) Evidence that pentoxifylline reverses acute renal dysfunction in bone marrow transplant recipients receiving amphotericin B and cyclosporine. Transplantation 51: 925–926

    PubMed  Google Scholar 

  60. Cutaia M, Bullard S, Rudio K, Rounds S (1993) Characteristics of amphotericin B-induced endothelial cell injury. J Lab Clin Med 121: 244–256

    PubMed  Google Scholar 

  61. Tolins J, Raij L (1991) Amphotericin B nephrotoxicity in the rat: protective effect of calcium channel blockade. J Am Soc Nephrol 2: 98–102

    PubMed  Google Scholar 

  62. Joly V, Saint-Julien L, Carbon C, Yeni P (1990) Interactions of free and liposomal amphotericin B with renal proximal tubular cells. J Pharmacol Exp Ther 255: 17–22

    PubMed  Google Scholar 

  63. Zager R, Bredl C, Schimpf B (1992) Direct amphotericin B-mediated tubular toxicity: assessments of selected cytoprotective agents. Kidney Int 41: 1588–1594

    PubMed  Google Scholar 

  64. Frindt G, Windhager E (1990) Ca-dependent inhibition of sodium transport in rabbit cortical collecting tubules. Am J Physiol 258: F568-F582

    PubMed  Google Scholar 

  65. Braden G, Singer I, Cox M (1985) Nephrogenic diabetes insipidus. In: Gonick H, Buckalew V (eds) Renal tubular disorders, Dekker, New York, pp 419–421

    Google Scholar 

  66. DuBose T, Caflisch C (1985) Validation of the difference in urine and blood carbon dioxide tension during bicarbonate loading as an index of distal nephron acidification in experimental models of distal renal tubular acidosis. J Clin Invest 75: 1116–1123

    PubMed  Google Scholar 

  67. Skinner R, Sharkey IM, Pearson ADJ, Craft AW (1993) Ifosfamide, MESNA, and nephrotoxicity in children. J Clin Oncol 11: 173–190

    PubMed  Google Scholar 

  68. Carlisle EJ, Donnelly SM, Halperin ML (1991) Renal tubular acidosis (RTA): recognize the ammonium defect and pHorget the urine pH. Pediatr Nephrol 5: 242–248

    PubMed  Google Scholar 

  69. Alon U, Hellerstein S, Warady BA (1991) Oral acetazolamide in the assessment of (urine-blood)PCO2. Pediatr Nephrol 5: 307–311

    PubMed  Google Scholar 

  70. Strife CF, Clardy CW, Varade WS, Prada AL, Waldo FB (1993) Urine-to-blood carbon dioxide tension gradient and maximal depression of urinary pH to distinguish rate-dependent from classic distal renal tubular acidosis in children. J Pediatr 122: 60–65

    PubMed  Google Scholar 

  71. Alon U, Hellerstein S (1994) Assessment and interpretation of the tubular threshold for phosphate in infants and children. Pediatr Nephrol (in press)

  72. Womer RB, Pritchard J, Barratt TM (1985) Renal toxicity of cisplatin in children. J Pediatr 106: 659–663

    PubMed  Google Scholar 

  73. Jaffe N, Keifer R, Robertson R, Cangir A, Wang A (1987) Renal toxicity with cumulative doses ofcis-diamminedichloroplainium-II in pediatric patients with osteosarcoma. Effect of creatinine clearance and methotrexate excretion. Cancer 59: 1577–1581

    PubMed  Google Scholar 

  74. Mavischak V, Wong NLM, Quamma GA, Magil AB, Sutton RAL, Dirks JH (1985) Studies on the pathogenesis of cisplatin-induced hypomagnesemia in rats. Kidney Int 28: 914–921

    PubMed  Google Scholar 

  75. Daugaard G, Abildgaard U, Holstein-Rathlou N-H, Bruunshuus I, Bucher D, Leyssac PP (1988) Renal tubular function in patients treated with high-dose cisplatin. Clin Pharmacol Ther 44: 164–172

    PubMed  Google Scholar 

  76. Jongerjan HTM, Provoost AP, Wolff ED, Molenaar JC (1986) Nephrotoxicity of cisplatin comparing young and adult rats. Pediatr Res 20: 9–14

    PubMed  Google Scholar 

  77. Bianchetti MG, Kanaka C, Ridolfi-Luthi A, Hirt A, Wagner HP, Oetliker OH (1991) Persisting renotubular sequelae after cisplatin in children and adolescents. Am J Nephrol 11: 127–130

    PubMed  Google Scholar 

  78. Dirks JH (1983) The kidney and magnesium regulation. Kidney Int 23: 771–777

    PubMed  Google Scholar 

  79. Mavichak V, Wong NLM, Quamme GA, Magil AB, Sutton RAL, Dirks JH (1985) Studies on the pathogenesis of cisplatin-induced hypomagnesemia in rats. Kidney Int 28: 914–921

    PubMed  Google Scholar 

  80. Chazali S, Barratt TM (1974) Urinary excretion of calcium and magnesium in children. Arch Dis Child 49: 97–101

    PubMed  Google Scholar 

  81. Massry SG, Seelig MS (1977) Hypomagnesemia and hypermagnesemia. Clin Nephrol 7: 147–153

    PubMed  Google Scholar 

  82. Koren G (1989) The nephrotoxic potential of drugs and chemicals: pharmacological basis and clinical relevance. Med Toxicol 4: 59–72

    Google Scholar 

  83. Sabra R, Branch RA (1990) Amphotericin B nephrotoxicity. Drug Safety 5: 94–108

    PubMed  Google Scholar 

  84. Fisher MA, Talbot GH, McKeon BP, Tynan K, Strom BL (1989) Risk factors for amphotericin B-associated nephrotoxicity. Am J Med 87: 547–552

    PubMed  Google Scholar 

  85. Branch RA (1988) Prevention of amphotericin B — induced renal impairment — a review of the use of sodium supplementation. Arch Intern Med 148: 2389–2394

    PubMed  Google Scholar 

  86. Koren G, Lau A, Klein J, Golas C, Bologa-Campeanu M, Soldin S, MacLeod S, Prober C (1988) Pharmacokinetics and adverse effects of amphotericin B in infants and children. J Pediatr 113: 559–563

    PubMed  Google Scholar 

  87. Ohnishi A, Ohnishi T, Stevenhead W, Robinson RD, Glick A, O'Day DM, Sabra R, Jackson EK, Branch RA (1989) Sodium status influences chronic amphotericin B nephrotoxicity in rats. Am Soc Microbiol 33: 1222–1227

    Google Scholar 

  88. Bullock WE, Luke RG, Nattall CE, Bhathena D (1976) Can mannitol reduce amphotericin B nephrotoxicity: double-blind study and description of a new vascular lesion in kidneys. Am Soc Microbiol 10: 555–563

    Google Scholar 

  89. Gallis HA, Drew RH, Pickard WW (1990) Amphotericin B: 30 years of clinical experience. Rev Infect Dis 12: 308–329

    PubMed  Google Scholar 

  90. Butler WT, Bennett JE, Alling DW, Wertlake PT, Utz JP, Hill GJ II (1964) Nephrotoxicity of amphotericin B — early and late effects in 81 patients. Ann Intern Med 61: 175–187

    PubMed  Google Scholar 

  91. Barton CH, Pahl M, Vaziri ND, Cesario T (1984) Renal magnesium wasting associated with amphotericin B therapy. Am J Med 77: 471–474

    PubMed  Google Scholar 

  92. Miller RP, Bates JH (1969) Amphotericin B toxicity — a follow-up report of 53 patients. Ann Intern Med 71: 1089–1095

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Chief of Pediatric Nephrology, Professor of Pediatrics, University of Wisconsin Childrens Hospital, 600 Highland Avenue, 53792-4108, Madison, WI, USA

    Aaron Friedman (Editor)

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  1. Aaron Friedman
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  2. John Mahan
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  3. Uri Alon
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The American Society of Pediatric Nephrology (ASPN) is comprised of nephrologists in North America interested in the care of children and adolescents with kidney and urological diseases. The ASPN sponsors an annual educational symposium which is the major forum for the educational mission of the society. The following is a synopsis of the 1993 ASPN Educational Symposium

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Friedman, A., Mahan, J. & Alon, U. Proceedings of the American Society of Pediatric Nephrology 1993 Education Symposium, Washington, D. C., 4 May, 1993. Pediatr Nephrol 8, 632–640 (1994). https://doi.org/10.1007/BF00858151

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