Summary
Age is known to be associated with the development of glucose intolerance. In this review an effort has been made to differentiate between the effects of age per se on glucose tolerance, as distinguished from those of such age-related variables as obesity, diet, development of frank diabetes, etc. At the same time, an attempt was made to evaluate the evidence implicating abnormalities of insulin secretaion and/or insulin action in the development of glucose intolerance with age. It is concluded that the questions being asked are far from simple, and that available data do not provide unequivocal answers.
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References
Andres, R. and Tobin, J. D., 1977.In Handbook of Biology of Aging (Finch and Hayflick, Editors), p. 357–377.
Reaven, G., 1977. Geriatrics, 35, 51–54.
Davidson, M., 1979. Metabolism 28, 688–705.
Wingerd, J. and Duffy, T. J., 1977. Diabetes 26, 1024–1033.
Nolan, S., Thorsten, S., Chae, C., Vidalon, C., Gegick, C., Khurana, R., and Donawski, T. S., 1973. J. Amer. Geriatric Soc. 21, 106–111.
Bohns, D. R., Crossley, J. N., Abrams, M. E., Jarrett, R. J., and Keen, H., 1969. Brit. Med. J. March 8, 595–602.
Kimmerling, G., Javorski, W. C., and Reaven, G. M., 1977. J. Amer. Geriatric Soc. 25, 349–353.
Rehfeld, J. R. and Stadil, F., 1975. Europ. J. Clin. Invest. 5, 273–283.
Berger, D., Crowther, R. C., Floyd, J. C., Pek, S., and Fajans, S. S., 1978. J. Clin. Endocrin. Metab. 47, 1183–1189.
O'Sullivan, J. B., Mahan, C. M., Freedlender, A. E., and Willians, R. F., 1971. J. Clin. Endocrin. Metab. 33, 619–623.
Nilsson, S. E., Lindholm, H., Bulow, S., Frostberg, N., Emilsson, T., and Stenkula, G., 1964. Acta Med. Scand. (Suppl) 428, 1–42.
Vecchio, T. J., Oster, H. L., and Smith, D. L., 1965. Arch. Int. Med. 115, 161–166.
Franckson, J. R. M., Malaise, W., Arnould, Y., Rasio, E., Corns, H. A., Balasse, E., Conard, V., and Bastenie, P. A., 1966. Diabetologia 2, 96–103.
Dyck, D. R. and Moorhouse, J. A., 1966. H. Clin. Endocrin. Metab. 26, 1032–1038.
Swerdloff, R. S., Pozefsky, T., Tobin, J. D., and Andres, R., 1967. Diabetes 16, 161–170.
Klimas, J. E., 1968. J. Gerontology 23, 31–34.
Gommers, A. and DeGasparo, M., 1972. Gerontologia 18, 176–184.
Vranic, M. and Pokrajac, N., 1961 J. gerontology 16, 110–113.
Hoffmen, C. C., Carroll, K. F., and Goldrick, R. B., 1972. Austr. J. Exp. Biol. Med. Sci. 50, 267–287.
Brancho-Romero, E. and Reaven, G. M., 1977. J. Amer. Geriatrics Soc. 25, 299–302.
Lavine, J. L., Chick, W. L., Like, A. A., and Makdisi, T. W., 1971. Diabetes 20, 134–139.
Berdanier, C. D., Marshall, M. W., and Moser, P., 1971. Life Sci. 10, 105–109.
O'Sullivan, J. B., 1974. Diabetes 23, 713–715.
Rushforth, N. B., Bennett, P. H., Steinberg, A. G., Burch, T. A., and Miller, M., 1971. Diabetes 20. 756–765.
Zimmet, P. and Whitehouse, S., 1979. Diabetes 28, 617–623.
Kaufmann, B. J., Grant, D. R., and Moorhouse, J. A., 1969. Canad. Med. Assoc. J. 100, 692–698.
Duckworth, W. C. and Kitabchi, A. E., 1976. J. Lab. Clin. Med. 88, 359–367.
Peterson, D. T. and Reaven, G. M., 1971. Diabetes 20, 729–733.
Olefsky, J. M., Batchelder, T., Farquhar, J. W., and Reaven, G. M., 1973. Metabolism 22, 1277–1286.
Reaven, E. P., Gold, G., and Reaven, G. M., 1979. J. Clin. Invest. 64, 591–599.
Silverstone, F. A., Brandfonbrener, M., Shock, N. W., and Yiengst, M. J., 1957. J. Clin. Invest. 36, 504–514.
Martin, F. I. R., Pearson, M. J., and Stocks, A. E., 1968. Lancet 1, 1285–1286.
Kalk, W. J., Vinik, A. I., Pimstone, B. L., and Jackson, W. P. U., 1973. J. Gerontology 28, 431–433.
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Reaven, G.M., Reaven, E.P. Effects of age on various aspects of glucose and insulin metabolism. Mol Cell Biochem 31, 37–47 (1980). https://doi.org/10.1007/BF00817889
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DOI: https://doi.org/10.1007/BF00817889