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7,8-Disubstituted [1,3]-thiazino-[2,3-f]-purine derivatives

7,8-Disubstituierte [1,3]-Thiazino-[2,3-f]-purinderivate

  • Organische Chemie Und Biochemie
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Summary

7-Cyanomethyl-8-ethoxycarbonylmethylthio- (3a), 7-cyanomethyl-8-cyanomethylthio- (3b) and 7-ethoxycarbonylmethyl-8-ethoxycarbonylmethylthio-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (3c) afforded 7-amino-8-ethyoxycarbonyl-(5), 7-amino-8-cyano- (6), and 8-ethoxycarbonyl-7-hydroxy-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-6H-[1,3]-thiazino-[2,3-f]-purine (7), respectively, on intramolecular Claisen-type condensation.

Zusammenfassung

7-Cyanomethyl-8-ethoxycarbonylmethylthio- (3a), 7-Cyanomethyl-8-cyanomethylthio- (3b) und 7-Ethoxycarbonylmethyl-8-ethoxycarbonylmethylthio-1,3-dimethyl-3,7-dihydro-1H-purin-2,6-dion (3c) liefern bei einer intramolekularen Claisen-Kondensation die 7-Amino-8-ethoxy-carbonyl-(5), 7-Amino-8-cyano- (6), und 8-Ethoxycarbonyl-7-hydroxy-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-6H-[1,3]-thiazino-[2,3-f]-purine (7).

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Authors and Affiliations

  1. Drug Research Institute, 900 01, Modra, Slovakia

    Dušan Hesek

  2. Institute of Chemistry, Slovak Academy of Sciences, 842 38, Bratislava, Slovakia

    Alfonz Rybár

Authors
  1. Dušan Hesek
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  2. Alfonz Rybár
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Hesek, D., Rybár, A. 7,8-Disubstituted [1,3]-thiazino-[2,3-f]-purine derivatives. Monatsh Chem 124, 1143–1148 (1993). https://doi.org/10.1007/BF00810022

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  • DOI: https://doi.org/10.1007/BF00810022

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