Abstract
Direct correlation was found in intact rats between the kallikrein activity of the urine, on the one hand, and the diuresis, sodium excretion, and ability of the kidneys to concentrate the urine on the other hand. Small doses of indomethacin (2 mg/kg for 5 days) increased the kallikrein activity of the urine four-fold and, at the same time, increased the diuresis; large doses (5 mg/kg for 5 days) lowered the kallikrein activity of the urine and halved the diuresis, reduced the sodium excretion by two-thirds, and depressed the ability of the kidneys to concentrate the urine. Indomethacin may perhaps modify the synthesis not only of prostaglandins, but also of kallikrein, and this is reflected in the state of the kidney function.
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Nekrasova, A.A., Zharova, E.A. & Sokolova, R.I. Role of the kallikrein-kinin system of the kidneys in sodium and water transport and its modification by indomethacin. Bull Exp Biol Med 83, 456–458 (1977). https://doi.org/10.1007/BF00807474
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DOI: https://doi.org/10.1007/BF00807474