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Antibodies in the study of multiple drug resistance

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Abstract

Multidrug resistance (MDR) is a major problem in cancer chemotherapy. As P-glycoprotein is the key molecule in MDR, many investigators have constructed anti-P-glycoprotein monoclonal antibodies (MAbs). Those antibodies, including MRK16 and C219, were used for elucidation of the mechanism of MDR and for overcoming of MDR. This article describes the characterization of the antibodies against the P-glycoprotein and other proteins of multidrug-resistant tumor cells, and discusses the therapeutic implication of the antibodies.

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Abbreviations

ADCC:

antibody-dependent cell-mediated cytotoxicity

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  1. Pharmacology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, 104, Chuo-ku, Tokyo, Japan

    Yuji Heike & Takashi Tsuruo

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Heike, Y., Tsuruo, T. Antibodies in the study of multiple drug resistance. Cytotechnology 12, 91–107 (1993). https://doi.org/10.1007/BF00744659

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  • DOI: https://doi.org/10.1007/BF00744659

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