Summary
In the present study, the diameters of afferent and efferent arterioles of kidneys from spontaneously hypertensive rats (SHR) were evaluated and compared with those from Wistar Kyoto rats (WKY) using a vascular cast model. At 4 weeks of age, the blood pressure was slightly higher in SHR than in WKY (124±1 vs 116±7 mmHg, ns). The diameters of afferent arterioles in SHR were smaller than those in WKY (10.3±0.6 vs 12.3±0.7 µm,P<0.001), whereas the diameters of efferent arterioles were comparable in the two strains. At 20 weeks of age, the blood pressure was markedly elevated in SHR than in WKY (192±5 vs 140±4 mmHg,P<0.001). The diameters of afferent arterioles in SHR at this age were much smaller than those in WKY (14.3±0.5 vs 17.1±0.6 µm,P<0.01). The diameters of efferent arterioles in SHR were, however, larger than those in WKY (15.4±l.2 vs 12.9±0.4 µm,P< 0.05). The net effect of these changes in arteriolar size helps to maintain normal intraglomerular pressure and to protect glomeruli from damage due to hypertension.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bank N, Alterman L, Aynedjian HS (1983) Selective deep nephron hyperfiltration in uninephrectomized spontaneously hypertensive rats. Kidney Int 24:185–191
Brenner BM (1985) Nephron adaptation to renal injury or ablation. Am J Physiol 249:F324-F337
Brenner BM, Dworkin LD, Ichikawa I (1986) Glomerular filtration. In: Brenner BM, Rector FC (eds) The kidney. Volume I. Saunders, Philadelphia, pp 124–144
Dilley JR, Stier CT, Arendshorst WJ (1984) Abnormalities in glomerular function in rats developing spontaneous hypertension. Am J Physiol 246:FI2-F20
Dworkin LD, Hostetter TH, Rennke HG, Brenner BM (1984) Hemodynamic basis for glomerular injury in rats withdeoxycorticosterone-salt hypertension. J Clin Invest 73:1448–1461
Dworkin LD, Feiner HD (1986) Glomerular injury in uninephrectomized spontaneously hypertensive rats. A consequence of glomerular capillary hypertension. J Clin Invest 77:797–809
Gattone VH, Evan AP, Willis LR, Luft FC (1983) Renal afferent arteriole in the spontaneously hypertensive rat. Hypertension 5:8–16
Gattone VH, Shattuck M, Luft FC, Overhage JM, Willis LR,Evan AP (1984) Effect of denervation on the afferent arteriole in the SHR. Jpn Heart J 25:745–753
Gattone VH, Evan AP (1986) Quantitative renal vascular casting in nephrology research. Scan Electron Microsc I:253–262
Hostetter TH, Olsen JL, Rennke HG, Venkatachalam MA, Brenner BM (1981) Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. Am J Physiol 241:F85-F93
Hsu CH, Slavicek JM (1982) The effect of renal perfusion pressure on renal vascular resistance in the spontaneously hypertensive rat. Pflügers Arch 393:340–343
Wilson SK (1986) The effects of angiotensin II and norepinephrine on afferent arterioles in the rat. Kidney Int 30:895–905
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kimura, K., Nanba, S., Tojo, A. et al. Variations in arterioles in spontaneously hypertensive rats. Vichows Archiv A Pathol Anat 415, 565–569 (1989). https://doi.org/10.1007/BF00718651
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00718651