Summary
Two “sporadic” cases of amyloid polyneuropathy are reported. There was no family history or plasma cell dyscrasia. Both showed sensorimotor and autonomic polyneuropathy with onset in the seventh decade. Amyloid deposits in both cases reacted with anti-human prealbumin sera but not with antisera to human AA and anti-human immunoglobulin light-chain amyloids, including Aκ and Aλ. One patient had the abnormal serum prealbumin and abnormal DNA sequence found in type I familial amyloid polyneuropathy (FAP) (Japanese type). Investigations in “sporadic” amyloid polyneuropathy should include immunohistochemistry, using antisera to the different amyloid proteins, and the radioimmunoassay and recombinant DNA techniques for diagnosis of FAP.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Araki S (1985) Amyloidosis and amyloid polyneuropathy. Seiwa Shoten, Tokyo
Araki S, Mawatari S, Ohta M, Nakajima A, Kuroiwa Y (1968) Polyneuritic amyloidosis in a Japanese family. Arch Neurol 18:593–602
Dalakas MC, Cunningham G (1986) Characterization of amyloid deposits in biopsies of 15 patients with “sporadic” (non-familial or plasma cell dyscrasic) amyloid polyneuropathy. Acta Neuropathol (Berl) 69:66–72
Dwulet FE, Benson MD (1986) Characterization of a transthyretin (prealbumin) variant associated with familial amyloidotic polyneuropathy type II (Indiana/Swiss). J Clin Invest 78:880–886
Feurle GE, Linke RP, Kuhn E, Wagner A (1984) Clinical value of immunohistochemistry with AF-antibody in the diagnosis of familial amyloid polyneuropathy. J Neurol 231:237–243
Fujihara S, Balow JE, Costa JC, Glenner GG (1980) Identification and classification of amyloid in formalin-fixed, paraffin-embedded tissue sections by the unlabeled immunoperoidase method. Lab Invest 43:358–365
Glenner GG, Ignaczak TE, Page DL (1978) The inherited systemic amyloidoses and localized amyloid deposits. In: Stanbury JB, Wyngaarden JB, Fredrickson DS (eds) The metabolic basis of inherited disease, 4th edn. McGraw-Hill, New York, pp 1308–1339
Ingenbleek Y, van den Schrieck HG, de Nayer P, de Visscher M (1975) Albumin, transferrin and the thyroxine-binding prealbumin/retinol-binding protein (TBPA-RBP) complex in assessment of malnutrition. Clin Chim Acta 63:61–67
Ikeda S, Koh CS, Miyasaka M, Yanagisawa N, Tsukagoshi H (1981) Familial amyloid neuropathy with late onset and benign course. Clin Neurol (Tokyo) 21:135–142
Kelly JJ, Kyle RA, O'Brien PC, Dyck PJ (1977) The natural history of peripheral neuropathy in primary systemic amyloidosis. Ann Neurol 6:1–7
Kito S, Itoga E, Kamiya K, Kishida T, Yamamura Y (1980) Studies on familial amyloid polyneuropathy in Ogawa village, Japan. Eur Neurol 19:141–151
Kyle RA, Greipp PR (1983) Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc 58:665–683
Libbey CA, Rubinow A, Shirahama T, Deal C, Cohen AS (1984) Familial amyloid polyneuropathy. Demonstration of prealbumin in a kinship of German/English ancestry with onset in the seventh decade. Am J Med 76:18–24
Mita S, Maeda S, Ide M, Tsuzuki T, Shimada K, Araki S (1986) Familial amyloidotic polyneuropathy diagnosed by cloned human prealbumin cDNA. Neurology 36:298–301
Nakazato M, Kangawa K, Minamino N, Tawara S, Matsuo H, Araki S (1984) Identification of a prealbumin variant in the serum of a Japanese patient with familial amyloidotic polyneuropathy. Biochem Biophys Res Commun 122:712–718
Nakazato M, Kangawa K, Minamino N, Tawara S, Matsuo H, Araki S (1984) Radioimmunoassay for detecting abnormal prealbumin in the serum for diagnosis of familial amyloidotic polyneuropathy (Japanese type). Biochem Biophys Res Commun 122:719–725
Nakazato M, Kangawa K, Minamino N, Tawara S, Matsuo H, Araki S (1984) Revised analysis of amino acid replacement in a prealbumin variant (SKO-III) associated with familial amyloidotic polyneuropathy of Jewish origin. Biochem Biophys Res Commun 123:921–928
Ochiai J, Tobimatsu S, Kobayashi T, Kitamoto T, Kitaguchi T, Furuya H, Goto I, Kuroiwa Y (1986) Nonfamilial prealbumin-type amyloid polyneuropathy. Arch Neurol 43:1294–1295
Pitkänen P, Westermark P, Cornwell III GG (1984) Senile systemic amyloidosis. Am J Pathol 117:391–399
Sasaki H, Sakaki Y, Matsuo H, Goto I, Kuroiwa Y, Sahashi I, Takahashi A, Shinoda T, Isobe T, Takagi Y (1984) Diagnosis of familial amyloidotic polyneuropathy by recombinant DNA techniques. Biochem Biophys Res Commun 125:636–642
Sletten K, Westermark P, Natvig JB (1980) Cardiac amyloid is related to prealbumin. Scand J Immunol 12:503–506
Tawara S, Nakazato M, Kangawa K, Matsuo H, Araki S (1983) Identification of amyloid prealbumin variant in familial amyloidotic polyneuropathy (Japanese type). Biochem Biophys Res Commum 116:880–888
Wallace MR, Dwulet FE, Conneally PM, Benson MD (1986) Biochemical and molecular genetic characterization of a new variant of prealbumin associated with hereditary amyloidosis. J Clin Invest 78:6–12
Westermark P, Pitkänen P, Benson L, Vahlquist A, Olofsson BO, Cornwell III GG (1985) Serum prealbumin and retinol-binding protein in the prealbumin-related senile and familial forms of systemic amyloidosis. Lab Invest 52:314–318
Wright JR, Calkins E, Humphrey RL (1977) Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease. Lab Invest 36:274–281
Yamada M, Hatakeyama S, Tsukagoshi H (1984) Peripheral and autonomic nerve lesions in systemic amyloidosis. Three pathological types of amyloid polyneuropathy. Acta Pathol Jpn 34:1251–1266
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamada, M., Tsukagoshi, H., Satoh, J. et al. “Sporadic” prealbumin-related amyloid polyneuropathy: report of two cases. J Neurol 235, 69–73 (1987). https://doi.org/10.1007/BF00718012
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00718012