Summary
The areas of molecular and granular layers in four large cerebellar cortical dysplasias were measured with the planimeter and the Purkinje cells were counted. There was a relative deficit of molecular layer and a still greater deficit of Purkinje cells in three of the four dysplasias. The fourth one had normal numbers of Purkinje cells per molecular layer and a relative deficit of granular layer. These abnormal proportions in the composition of a dysplasia may relate to the timing of its origin.
Similar content being viewed by others
References
Altmann, J., Bayer, S. A.: Prenatal development of the cerebellar system in the rat. I. Cytogenesis and histogenesis of the deep nuclei and the cortex of the cerebellum. J. Comp. Neurol.179, 23–46 (1978)
Altman, J., Bayer, S. A.: Prenatal development of the cerebellar system in the rat. II. Cytogenesis and histogenesis of the inferior olive, pontine gray and the precerebellar reticular nuclei. J. Comp. Neurol.179, 49–76 (1978)
Altman, J., Das, G. D.: Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions. J. Comp. Neurol.126, 337–389 (1966)
Bellamy, J. C., D'Amato, N. A., Szakacs, J. E.: Diffuse cerebellar hypertrophy: Report of a case. Am. J. Clin. Pathol.40, 395–404 (1963)
Braitenberg, V., Atwood, R. P.: Morphological observations on the cerebellar cortex. J. Comp. Neurol.109, 1–27 (1958)
Das, G. D., Nornes, H. O.: Neurogenesis in the cerebellum of the rat: An autoradiographic study. Z. Anat. Entwickl. Gesch.138, 155–165 (1972)
Ebels, E. J.: Studies on ectopic granule cells in the cerebellar cortex-with a hypothesis as to their aetiology and pathogenesis. Acta Neuropathol. (Berl.)21, 117–127 (1972)
Ebels, E. J., Peters, I.: Studies on ectopic granule cells in the cerebellar cortex. II. The “data of birth” of the ectopic and normal granule cells after low-level X-irradiation. Acta Neuropathol. (Berl.)27, 271–275 (1974)
Friede, R. L.: Quantitative Verschiebungen der Schichten innerhalb des Windungsverlaufes der Kleinhirnrinde und ihre biologische Bedeutung. Acta Anat. (Basel)25, 65–72 (1955)
Friede, R. L.: Cerebellar edema: A metabolic and cellstatistical analysis. Arch. Neurol.8, 67–81 (1963)
Friede, R. L., Mikolasek, J.: Postencephalitic porencephaly, hydranencephaly or polymicrogyria. A review. Acta Neuropathol. (Berl.)43, 161–168 (1978)
Fujita, S., Shimada, M., Nakamura, T.: H3-thymidine autoradiographic studies on the cell proliferation and differentiation in the external and the internal granular layers of the mouse cerebellum. J. Comp. Neurol.128, 191–208 (1966)
Miale, I. L., Sidman, R. L.: An autoradiographic analysis of histogenesis in the mouse cerebellum. Exp. Neurol.4, 277–296 (1961)
Rakic, P.: Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. J. Comp. Neurol.141, 283–312 (1971)
Rorke, L. B., Fogelson, M. H., Riggs, H. E.: Cerebellar heterotopia in infancy. Dev. Med. Child Neurol.10, 644–650 (1968)
Sarnat, H. B., Netsky, M. G.: Evolution of the nervous system. pp. 113–148. New York, London, Toronto: Oxford University Press 1974
Sosa, J. M., Palacios, E., De Sosa, H. M. S.: Heterotopic cerebellar granule cells inside the plexiform layer. Acta Anat. (Basel)80, 91–98 (1971)
Uzman, L. L.: The histogenesis of the mouse cerebellum as studied by its tritiated thymidine uptake. J. Comp. Neurol.114, 137–159 (1960)
Woodard, J. S.: Origin of the external granular layer of the cerebellar cortex. J. Comp. Neurol.115, 65–73 (1960)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schalch, E., Friede, R.L. A quantitative study of the composition of cerebellar cortical dysplasias. Acta Neuropathol 47, 67–70 (1979). https://doi.org/10.1007/BF00698275
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00698275