Summary
Various parts of the central and peripheral nervous system of the mutant hamster with hind leg paralysis were studied in the electron microscope. A number of alterations involving the myelin sheath, the axon and certain neuronal perikarya were observed. Anterior horn cells were apparently well preserved. This condition represents an inherited form of peripheral neuropathy.
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References
Boquist, L.: Tubular cytoplasmic bodies in pancreatic islet B cells of mice. Z. Zellforsch.106, 69–78 (1970)
Carpenter, S.: Proximal axonal enlargement in motor neuron disease. Neurology (Minneap.)18, 841–851 (1968)
Chou, S.-M., Hartmann, H. H.: Electron microscopy of focal neuroaxonal lesions produced by β-β′-imminodipropionitrile (IDPN) in rats. Acta neuropath. (Berl.)4, 590–603 (1965)
Engel, W. K., Kurland, L. T., Klatzo, I.: An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermittent form? Brain82, 203–220 (1959)
Dick, P. J.: Segmental demyelination secondary to axonal degeneration in uremic neuropathy. Mayo Clin. Proc.46, 400–431 (1971)
Hirano, A.: Some current concepts of ALS. Neurol. Med. (Tokyo)4, 43–52 (1976)
Hirano, A.: Whorl formation in peripheral nerves in hamsters with hindleg paralysis. J. Neuropathol. Exp. Neurol.35, 323 (abstract) (1976)
Hirano, A., Dembitzer, H. M.: Eosinophilic rod-like structures in myelinated fibers of hamster spinal cord. J. Neuropathol. Appl. Neurobiol.2, 225–232 (1976)
Hirano, A., Kurland, L. T., Sayer, G. P.: Familial amyotrophic lateral sclerosis. A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells. Arch. Neurol.16, 232–243 (1967)
Homburger, F., Bajusz, E.: New models of human disease in Syrian hamsters. J.A.M.A.212, 604–610 (1970)
Nixon, C. W., Connelly, M. E.: Hind-leg paralysis: A new sexlinked mutation in the Syrian hamster. J. Heredity59, 276–278 (1968)
Spencer, P. A., Thomas, P. K.: Ultrastructural studies of the dyingback process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons. J. Neurocytol.3, 763–783 (1974)
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Hirano, A. Fine structural changes in the mutant hamster with hind leg paralysis. Acta Neuropathol 39, 225–230 (1977). https://doi.org/10.1007/BF00691701
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DOI: https://doi.org/10.1007/BF00691701