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Biosynthesis of hexamannophosphoinositides inMycobacterium smegmatis ATCC 607

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Abstract

The biosynthesis of hexamannophosphoinositides inMycobacterium smegmatis ATCC 607 was examined using labelled tri- and tetraacylated dimannophosphoinositides (PIM2-3F and PIM2-4F) as precursors, byin vivo andin vitro incorporation. Tetraacylated dimannoside was metabolically more active as compared to triacylated dimannoside and seems to be the precursor for the synthesis of hexamannophosphoinositides.

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Abbreviations

M. 607 :

Mycobacterium smegmatis ATCC 607

PIMs:

Mannophosphoinositides

PIM2-2F:

diacylated dimannoside

PIM2-3F:

triacylated dimannoside

PIM2-4F:

tetraacylated dimannoside

PIM3-3F:

triacylated trimannoside

PIM6-3F:

triacylated hexamannoside

PIM6-4F:

tetraacylated hexamannoside

GDP-mannose:

Guanosine diphosphomannose

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Authors and Affiliations

  1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India

    P. Nalini & G. K. Khuller

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  1. P. Nalini
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  2. G. K. Khuller
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Nalini, P., Khuller, G.K. Biosynthesis of hexamannophosphoinositides inMycobacterium smegmatis ATCC 607. Arch. Microbiol. 132, 87–90 (1982). https://doi.org/10.1007/BF00690824

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  • DOI: https://doi.org/10.1007/BF00690824

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