Summary
In a previous study the occurrence of nerve fibre degeneration with a distribution as in dying-back neuropathies was described in young rats subjected to severe protein deprivation (Oldfors 1981). In this study the ultrastructural appearance of the degeneration of the nerve fibres at different levels of the longitudinal tail nerves in severely protein-deprived rats has been investigated. Various structural changes were noted, the most common being bands of Büngner indistinguishable from those seen in Wallerian degeneration. In nerve fibres which were less severely affected the most common finding was shrinkage of the axon with concomitant folding of the myelin sheath. Other structural changes included axonal accumulation of 10 nm filaments or mitochondria and other cell organelles, areas of demyelination, and projections of axolemma and Schwann cell membrane into the axon. Signs of axonal regeneration occurred but were infrequent. The degenerative changes seen at various levels of the nerves support the view that the neuropathy is of distal axonal type, but the structural appearance differs from several of the toxic dying-back neuropathies.
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References
Banay-Schwartz M, Giuffrida AM, de Guzman T, Sershen H, Lajtha A (1979) Effect of undernutrition on cerebral protein metabolism. Exp Neurol 65:157–168
Bouldin TW, Cavanagh JB (1979) Organophosphorous neuropathy. II. A fine-structural study of the early stages of axonal degeneration. Am J Pathol 94:253–271
Bradley WG, Williams MH (1973) Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies. Brain 96:235–246
Collins GH, Webster HdeF, Victor M (1964) The ultrastructure of myelin and axonal alterations in sciatic nerves of thiamine-deficient and chronically starved rats. Acta Neuropathol (Berl) 3:511–523
Cravioto H (1969) Wallerian degeneration: Ultrastructural and histochemical studies. Bull Los Angeles Neurol Soc 4:233–253
Engsner G, Woldemariam T (1974) Motor nerve conduction velocity in marasmus and in kwashiorkor. Neuropädiatrie 5:34–48
Griffin JW, Price DL, Drachman DB (1977) Impaired axonal regeneration in acrylamide intoxication. J Neurobiol 8:355–370
Hamberger A, Sourander P (1978) The influence of early proteincalorie malnutrition on neuronal and glial protein synthesis. An experimental study on rats. Neurochem Res 3:535–547
Hughes AFW (1968) Aspects of neural ontogeny. Logos Press, London
Jacobs JM, Miller RH, Whittle A, Cavanagh JB (1979) Studies on the early changes in acute isoniazed neuropathy in the rat. Acta Neuropathol (Berl) 47:85–92
Mendell JR, Sahenk Z (1980) Interference of neuronal processing and axoplasmic transport by toxic chemicals. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology. Williams & Wilkins, Baltimore London, pp 139–160
Oldfors A (1981) Nerve fibre degeneration of the central and peripheral nervous systems in severe protein deprivation in rats. Acta Neuropathol (Berl) 54:121–127
Osuntokun BO (1971) Motor nerve conduction in kwashiorkor (protein-calorie deficiency) before and after treatment. Afr J Med Sci 2:109–119
Pawlik F, Bischoff A, Bitsch I (1977) Peripheral nerve changes in thiamine deficiency and starvation. An electron-microscopic study. Acta Neuropathol (Berl) 39:211–218
Prineas J (1969) The pathogenesis of dying-back polyneuropathies. Part II. An ultrastructural study of experimental acrylamide intoxication in the cat. J Neuropathol Exp Neurol 28:598–621
Rasool CG, Bradley WG (1978) Studies on axoplasmic transport of individual proteins. I. Acetyl cholinesterase (AChE) in acrylamide neuropathy. J Neurochem 31:419–425
Roy S, Singh N, Deo MG, Ramalingaswami V (1972) Ultrastructure of skeletal muscle and peripheral nerve in experimental protein deficiency and its correlation with nerve conduction studies. J Neurol Sci 17:399–409
Sabri MI, Spencer PS (1980) Toxic distal axonopathy: Biochemical studies and hypothetical mechanisms. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology. Williams & Wilkins, Baltimore London, pp 206–219
Sachdev KK, Taori GM, Pereira SM (1971) Neuromuscular status in protein-calorie malnutrition. Clinical, nerve conduction, and electromyographic studies. Neurology 21:801–805
Seppäläinen AM, Haltia M (1980) Carbon disulphide. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology. Williams & Wilkins, Baltimore London, pp 356–373
Spencer PS, Schaumburg HH (1978) Pathobiology of neurotoxic axonal degeneration. In: Waxman SG (ed) Physiology and pathobiology of axons. Raven Press, New York, pp 265–282
Spencer PS, Couri D, Schaumburg HH (1980) n-Hexane and methyl n-butyl ketone. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology. Williams & Wilkins, Baltimore London, pp 456–475
Spencer PS, Schaumburg HH (1980) Experimental and clinical neurotoxicology. Williams & Wilkins, Baltimore London
Suzuki K, Pfaff LD (1973) Acrylamide neuropathy in rats. An electron-microscopic study of degeneration and regeneration. Acta Neuropathol (Berl) 24:197–213
Udani PM (1962) Kwashiorkor myelopathy. Indian J Child Health 11:498–501
Viteri F, Bèhar M, Arroyave G, Scrimshaw NS (1964) Clinical aspects of protein malnutrition. In: Munro HN, Allison JB (eds) Mammalian protein metabolism. Academic Press, New York London, pp 523–568
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Supported by grants from the Swedish Medical Research Council (to Prof. P. Sourander, Head of the Division), project no. B81-12X-03488-10A and by grants from the University of Göteborg
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Oldfors, A., Persson, M. Peripheral nerve fibre degeneration in protein-deprived young rats. Acta Neuropathol 57, 1–6 (1982). https://doi.org/10.1007/BF00688871
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DOI: https://doi.org/10.1007/BF00688871