Summary
A peculiar ultrastructural change of the cytoplasmic membrane is described. It concerns selective destruction of the outer leaflet of the luminal side of the capillary endothelium in the white matter of the rat brain. 30 min and 3h after intracerebral injection of arachidonic acid (AA). The cristae of the mitochondria disappeared in the endothelium of many capillaries. These changes were observed mainly in the central part of brain edema, where the extracellular space was markedly widened.
The possible mechanism whereby these changes developed is discussed.
This is a preview of subscription content, log in via an institution to check access.
References
Demopoulos HB, Flamm ES, Seligman ML, Mitamura JA, Ransohoff J (1979) Membrane perturbations in central nervous system injury: Theroretical basis for free radical damage and a review of the experimental data. In: Popp AJ, Bourke RS, Nelson LR, Kimelberg HK (eds) Neural trauma. Raven Press, New York, pp 63–78
Egan RW, Paxton J, Kuel FA Jr (1976) Mechanism for irreversible self-deactivation of prostaglandin synthetase. J Biol Chem 251:7329–7335
Gaudet RJ, Levine L (1979) Transient cerebral ischemia and brain prostaglandins. Biochem Biophys Res Commun 86:893–901
Klatzo I (1967) Presidental address. Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 26:1–14
König JFR, Klippel RA (1967) The rat brain. A stereotaxic atlas of the forebrain and lower parts of the brain stem. Krieger, New York
Kontos HA, Wei EP, Povlishock JT, Dietrich WD, Magiera CJ, Ellis EF (1980) Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science 209:1242–1244
Moncada S, Vane JR (1979) Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med 300:1142–1147
Palay SL, McGee-Russell SM, Gordon SFr, Grillo MA (1962) Fixation of neural tissues for electron microscopy by perfusion with solutions of osmium tetroxide. J Cell Biol 12:385–410
Palay SL, Chan-Palay V (1974) Cerebellar cortex — Cytology and organization. Springer, Berlin Heidelberg New York
Sasaki T, Wakai S, Asano T, Watanabe T, Kirino T, Sano K (1981) The effect of a lipid hydroperoxide of arachidonic acid on the canine basilar artery. An experimental study on cerebral vasospasm. J Neurosurg 54:357–365
Siesjö BK (1981) Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metab 1:155–185
Tappel AL (1973) Lipid peroxidation damage, to cell components. Fed Proc 32:1870–1874
Yoshida S, Inoh S, Asano T, Sano K, Kubota M, Shimazaki H, Ueta N (1980) Effect of transient ischemia on free fatty acids and phospholipids in the gerbil brain. Lipid peroxidation as a possible cause of postischemic injury. J Neurosurg 53:323–331
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wakai, S., Aritake, K., Asano, T. et al. Selective destruction of the outer leaflet of the capillary endothelial membrane after intracerebral injection of arachidonic acid in the rat. Acta Neuropathol 58, 303–306 (1982). https://doi.org/10.1007/BF00688614
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688614