Summary
Large dense core vesicles (LDCV) were found frequently enough in normal guinea pig central white matter, basis pontis and spinal cord posterior columns to be regarded as a normal organelle. A review of studies of LDCV and dense core particles (DCP), which have a different cytological localization and appear to be associated with a variety of diseases, suggests that they are the same, and hence remarkably ubiquitous. LDCV should no longer be regarded as a type of synaptic vesicle, but as an incompletely defined organelle common to many cell types.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andrews, J. M.: The ultrastructural neuropathology of multiple sclerosis, 23–52. In: Multiple sclerosis immunology, virology and ultrastructure, F. Wolfgram, G. W. Ellison, J. G. Stevens and J. M. Andrews, (Eds.). New York: Academic Press 1962
Andrews, J. M., Andrews, M. A.: The significance of dense core particles in subacute demyelinating disease in an adult. Lab. Invest.28, 236–243 (1973)
Andrews, J. M., Vernand, R. L.: Basic concepts of ultrastructural anatomy. Bull. Los Angeles neurol. Soc.36, 131–155 (1971)
Banks, P., Mayor, D., Tomlinson, D. R.: Further evidence for the involvement of microtubules in the intra-axonal movement of noradrenaline storage granules. J. Physiol. (Lond.)219, 755–761 (1971)
Bots, G. T., Man, J. C. de, Verjaal, A.: Virus-like particles in brain tissue from two patients with Creutzfeldt-Jakob disease. Acta neuropath. (Berl.)18, 267–270 (1971)
Bouteille, M., Guazzi, G. C., Martin, J. J., Masselin, S., Houdart, R., Delarue, J.: Un cas d'encéphalite périaxile diffuse de Schilder: II. Etude ultrastructurale. Ann. Anat. path.13, 55–68 (1968)
Bouteille, M., Guazzi, G. C., Masselin, S., Houdart, R., Delarue, J.: Particules d'aspect viral observées au microscope électronique dans une biopsie cérébrale d'encéphalite péri-axile diffuse de Schilder. Presse méd.74, 2353–2354 (1966)
Bouteille, M., Vedrenne, C., Dupuy-Coin, A. M., Delarue, J.: Inclusions intranucléaires particulières observées au microscope électronique dans un cas d'encéphalitee aiguë nécrosante. Ann. Anat. path.12, 403–410 (1967)
Boyazis, R. M., Martin, L., Bouteille, M., Guazzi, G. C., Manacorda, A.: Images histochimiques et ultrastructurales dans un cas de sclérose en plaque associée á un spongioblastome. Riv. Pat. nerv. ment.88, 1–20 (1967)
Duncan, D., Morales, R.: Location of large core synaptic vesicles in the dorsal gray matter of the cat and dog spinal cord. Amer. J. Anat.136, 123–127 (1973)
Elizan, T. S., Schwarty, J., Kott, E., Pedersen, B.: Schilder's Disease: virology studies concerning dense core particles. Neurology (Minneap.)24, 428–430 (1974)
Fuxe, K., Hökfelt, T., Nilsson, O.: A fluorescence and electronmicroscopic study on certain brain regions rich in monoamine terminals. Amer. J. Anat.117, 33–46 (1965)
Gonatas, N. K., Martin, J., Evangelista, I.: The osmophilic particles of astrocytes. Viruses, lipid droplets or products of secretion? J. Neuropath. exp. Neurol.26, 369–376 (1967)
Gonatas, N. K., Shy, G. M.: Virus-like particles in subacute sclerosing encephalitis. Nature (Lond.)208, 1338–1339 (1965)
Grillo, M., Palay, S. L.: Granule-containing vesicles in the autonomic nervous system. In: Electron microscopy, S. S. Breese, Jr. (Ed.) New York: Academic Press 1963
Hökfelt, T.: On the ultrastructural localization of noradrenaline in the central nervous system of the rat. Z. Zellforsch., Abt. Histochem.79, 110–117 (1967)
Hökfelt, T.: The possible ultrastructural identification of tubero-infundibular dopamine containing nerve endings in the median eminence of the rat. Brain Res.5, 121–123 (1967)
Ishii, S., Nakamura, I.: Electron microscopic study on the large granulated vesicles in enlarged axons of the area postrema. J. Electron Mic.21, 85–88 (1972)
McCracken, R. M., Dow, C.: An electron microscopic study of Aujesky's Disease. Acta neuropath. (Berl.)25, 207–219 (1973)
Pellegrino De Iraldi, A., De Robertis, E.: The neurotubular system of the axon and the origin of granulated and nongranulated vesicles in regenerating nerves. Z. Zellforsch., Abt. Histochem.87, 330–344 (1968)
Pellegrino De Iraldi, A., Duggan, H. F., De Robertis, E.: Adrenergic synaptic vesicles in the anterior hypothalamus of the rat. Anat. Rec.145, 521–531 (1963)
Pellegrino De Iraldi, A., Etcheverry, G. J.: Ultrastructural changes in the nerve endings of the median eminence after nialamide-DOPA administration. Brain Res.6, 614–618 (1967)
Peters, A., Palay, S. L., Webster, H. De F.: The fine structure of the nervous system. New York-Evanston-London: Harper and Row 1970
Pick, J.: On the submicroscopic organization of the myelinated sympathetic nerve fiber in the frog (Rana pipiens). Anat. Rec.144, 295–325 (1962)
Powell, H. C., London, G. W., Lampert, P. W.: Neurofibrillary tangles in progressive supranuclear palsy. J. Neuropath. exp. Neurol.33, 98–106 (1974)
Sjöstrand, F. S.: Ultrastructure and function of cellular membranes, 151–210. In: The membranes, A. J. Dalton and F. Haguenau (Eds.) New York-London: Academic Press 1968
Smith, D. S., Jarlfors, U., Beranek, R.: The organization of synaptic axoplasm in the lamprey (Petromyzon marinus) central nervous system. J. Cell Biol.46, 199–219 (1970)
Suzuki, N., Grover, W. D.: Ultrastructural and biochemical studies of Schilder's disease: I. Ultrastructure. J. Neuropath. exp. Neurol.29, 392–404 (1970)
Telez-Nagel, I., Harter, D. H., Johnson, A. B., Carver, D.: Virus-like particles in subacute sclerosing encephalitis: Electron microscopic, neurological and histochemical studies. J. Neuropath. exp. Neurol.26, 121 (abstract) (1967)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Harvey, F.H. The large dense core vesicle: A normal organelle of the central nervous system myelinated axon. Acta Neuropathol 31, 91–96 (1975). https://doi.org/10.1007/BF00688142
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688142