Summary
The glycogen content and its topography and the activity of UDPglucose-glycogen glucosyltransferase in the brain of rats after CO intoxication were investigated. A transient increase in glycogen content and in the enzyme activity was noticed. The highest level of glycogen was observed after 4h and the most significant increase of the enzyme activity after 2h, returning to normal values after 120 h.
In the histochemical studies glycogen was deposited in the perivascular astrocytes, in their cytoplasm and astrocytic processes. These changes were localized in the cerebral and cerebellar cortex and in the grey formations of brain stem and were expressed mostly after 4, 6 and 12 h following CO intoxication.
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This work supported under Grant PL 480, Agreement No 05-004-1, sponsored by US Public Health Service.
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Śmiałek, M., Sikorska, M., Korthals, J. et al. The glycogen content and its topography and UDP glucose: Glycogen α-4 glucosyltransferase (EC 2.4.1.11). Activity in rat brain after experimental carbon monoxide intoxication. Acta Neuropathol 24, 222–231 (1973). https://doi.org/10.1007/BF00687592
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DOI: https://doi.org/10.1007/BF00687592