Summary
The effect of total asphyxia on dendritic development of the pyramidal cells in the mouse cerebrum was investigated using the Golgi-Cox method. Although neonatal asphyxia did not alter the number of basal dendrites arising from the cell bodies, the dendrites in the 20-day-old treated animals were significantly shorter than those in the controls. Even at 60 days, the number of longer dendrites in the treated mice was significantly less than that in the controls.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Balázs R, Lewis PD, Patel AJ (1975) Effects of metabolic factors on brain development. In: Brazier MAB (ed) Growth and development of the brain: nutritional, genetic and environmental factors. Raven Press, New York, pp 83–115
Caviness VS Jr (1975) Architectonic map of neocortex of the normal mouse. J Comp Neurol 164:247–264
Cragg BG (1970) Synapses and membranous bodies in experimental hypothyroidism. Brain Res 18:297–307
Dunn A, Giuditta A, Pagliuca N (1971) The effect of electroconvulsive shock on protein synthesis in mouse brain. J Neurochem 18:2093–2099
Earys JT (1955) The cerebral cortex of normal and hypothyroid rats. Acta Anat (Basel) 25:160–183
Faivre C, Legrand Ch, Rabié A (1983) Effects of thyroid deficiency and corrective effects of thyroxine on microtubules and mitochondria in cerebellar Purkinje cell dendrites of developing rats. Dev Brain Res 8:21–30
Freytag E, Lindenberg R (1967) Neuropathologic findings in patients of a hospital for the mentally deficient. A survey of 359 cases. Johns Hopkins Med J 121:379–392
Hammer RP Jr (1981) The influence of pre-and postnatal undernutrition on the developing brain stem reticular core: a quantitative Golgi study. Dev Brain Res 1:191–201
Huttenlocher PR (1974) Dendritic development in neocortex of children with mental defect and infantile spasms. Neurology 24:203–210
Komatsu S, Naruse H, Nagayama M (1979) Effect of experimental neonatal asphyxia on protein metabolism in rat brain (in Japanese). No to Hattatsu 11:285–294
Leuba G, Rabinowicz Th (1979) Long-term effects of postnatal undernutrition and maternal malnutrition on mouse cerebral cortex. II. Evolution of dendritic branchings and spines in the visual region. Exp Brain Res 37:299–308
Morikawa Y (1978) Effects of early malnutrition on brain development. II. Effects of early malnutrition on cortical dendritic growth in mice (in Japanese). No to Hattatsu 10:218–224
Myers RE (1972) Two patterns of perinatal brain damage and their conditions of occurrence. Am J Obstet Gynecol 112:246–276
Purpura DP (1974) Dendritic spine “dysgenesis” and mental retardation. Science 186:1126–1128
Sholl DA (1953) Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 87:387–407
Volpe JJ (1981) Neurology of the newborn. Saunders. Philadelphia, pp 180–238
Wasterlain CG (1974) Inhibition of cerebral protein synthesis by epileptic seizures without motor manifestations. Neurology 24:175–180
Windle WF (1963) Neuropathology of certain forms of mental retardation. Science 140:1186–1189
Wise SP, Fleshman JW Jr, Jones EG (1979) Maturation of pyramidal cell form in relation to developing afferent and efferent connections of rat somatic sensory cortex. Neuroscience 4:1275–1297
Yoshida A, Yoshioka H, Kasubuchi Y, Kusunoki T (1984) Effects of early malnutrition and rehabilitation on brain development. Golgi-Cox study. Brain Dev 6:149
Yoshioka Y, Ochi M, Yoshida A, Iinos, Fujiwara K, Ishimura K, Nishimura O, Kusunoki T (1984) Effects of neonatal hypoxia on brain development. 5. Behavioral changes due to total asphyxia. Brain Dev 6:153
Yoshioka Y, Mino M, Morikawa Y, Kasubuchi Y, Kusunoki T (1985) Changes in cell proliferation kinetics in the mouse cerebellum after total asphyxia. Pediatrics 76:965–969
Author information
Authors and Affiliations
Additional information
Supported in part by Grant No. 85-15 from the National Center for Nervous, Mental and Muscular Disorders (NCNMMD) of the Ministry of Health and Welfare, Japan
Rights and permissions
About this article
Cite this article
Yoshioka, H., Yoshida, A., Ochi, M. et al. Dendritic development of cortical neurons of mice subjected to total asphyxia: A Golgi-Cox study. Acta Neuropathol 70, 185–189 (1986). https://doi.org/10.1007/BF00686070
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00686070