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Immuntoleranz gegen Blutgruppenantigene im Tierexperiment

Immune-tolerance to blood-group antigens in animal experiments

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Summary

200 guinea-pigs showed immunizing tendencies against factor “LW” which is closely related to the Rh'-antigen. In case the antigen was transferred to newborn guinea-pigs already within the first 6 hours after birth, these animals were unable to develop the respective specific antibodies later on. In all of 167 cases an immune-tolerance had developed, which possibly can be explained by a special overburdening of the immature immune-system shortly post partum.

The tendency for immunization against human erythrocytes in general was maintained. It is discussed whether application of the Rh-antigens to human rh-negative new-borns may achieve an immune-tolerance to the Rh-antigen.

Zusammenfassung

200 Meerschweinchen zeigten eine Immunisierungsbereitschaft gegen den Faktor „LW“, der dem Rh-Antigen nahe verwandt ist. Wurde das Antigen in den ersten 6 Std nach der Geburt bereits auf neugeborene Meerschweinchen übertragen, waren diese später nicht in der Lage, entsprechende spezifische Antikörper zu entwickeln. Es hatte sich in allen von 167 Fällen eine Immuntoleranz ausgebildet, die man vielleicht auf eine spezielle Überbeanspruchung des post partum noch unreifen Immunsystems zurückführen kann. Die Immunisierungsbereitschaft allgemein gegen menschliche Erythrocyten war erhalten geblieben. —Ob durch Zufuhr des Rh-Antigens bei menschlichen rh-negativen Neugeborenen eine Immuntoleranz gegen das Rh-Antigen erreicht werden kann, wird zur Diskussion gestellt.

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Literatur

  • Billingham, R. E., L. Brent, andP. B. Medawar: “Actively acquired tolerance” of foreign cells. Nature (Lond.)172, 603 (1953).

    Google Scholar 

  • Booth, P. B., G. Plaut, J. D. James, E. W. Ikin, Ph. Moores, R. Sanger, andR. R. Race: Blood chimerism in a pair of twins. Brit. med. J.1957 I, 1456.

    Google Scholar 

  • Brambell, R., andN. A. Mitchinson: Zit. nach R. R.Race, and R.Sanger, Blood groups in man, 3rd edit. Oxford: Blackwell Sci. Publ. 1958.

    Google Scholar 

  • Burnet, F. M., andF. Fenner: The production of antibodies, 2nd edition. Melbourne: Macmillan 1949.

    Google Scholar 

  • Dunsford, I., C. C.Bowley, A. M.Hutchison, J. S.Thompson, R.Sanger, and R. R.Race: A human blood-group chimera. Brit. med. J.1953, 81.

  • Landsteiner, K., andA. S. Wiener: An agglutinable factor in human blood recognizable by immune sera for Rhesus blood. Proc. Soc. exp. Biol. (N.Y.)43, 223 (1940).

    Google Scholar 

  • Levine, P., M. Celano, R. Fenichel, andR. Singher: A “D-like” antigen in Rhesus red blood cells and in Rh-positive and rh-negative red cells. Sci.133, 332 (1961).

    Google Scholar 

  • —: A “D-like” antigen in Rhesus-Monkey, human rh-positive and Rh-negative red blood cells. J. Immunol.87, 747 (1961).

    Google Scholar 

  • Mitchison, N. A.: Tolerance depending on presence of surviving red cells. Biological problems of grafting. Oxford: Blackwell Sci. Publ. 1959.

    Google Scholar 

  • Murray, J., andE. C. Clark: Production of anti-Rh in guinea pigs from human erythrocyte extracts. Nature (Lond.)169, 886 (1952).

    Google Scholar 

  • Nicholas, J. W., W. J. Jenkins, andW. L. Marsh: Human blood chimeras. Brit. med. J.1957 I, 1458.

    Google Scholar 

  • Owen, R. D.: Immunogenetic consequences of vascular anastomoses between bovine twins. Sci.102, 400 (1945).

    Google Scholar 

  • —: Evidence for actively acquired tolerance to Rh-Antigens. Proc. nat. Acad. Sci. (Wash.)44, 420 (1954).

    Google Scholar 

  • —: Erythrocyte antigens and tolerance phenomena. Proc. roy. Soc. B146, 8 (1956).

    Google Scholar 

  • Rendel, J.: Studies of cattle blood groups. III. Blood grouping as a method of diagnosing the zygosity of twins. Acta agric. scand.8, 162, 1958.

    Google Scholar 

  • Spielmann, W.: Versuche zur Gewinnung von Anti-Rh-Serum durch Immunisierung von Meerschweinchen. Arb. Paul Ehrlich-Inst.48, 104 (1950).

    Google Scholar 

  • Steffen, C.: Allgemeine und experimentelle Pathologie, S. 448. Stuttgart: Georg Thieme 1968.

    Google Scholar 

  • Woodroff: Mitteilung vonWestphal auf der 105. Verslg. d. Ges. Dtsch. Naturforscher und Ärzte. Heidelberg 1968.

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Authors and Affiliations

  1. Universitäts-Frauenklinik Erlangen-Nürnberg, Erlangen-Nürnberg

    P. Dördelmann, J. Jilo & H. Saalmüller

Authors
  1. P. Dördelmann
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  2. J. Jilo
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  3. H. Saalmüller
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In Kurzfassung vorgetragen auf dem „II. Deutschen Kongreß für Perinatale Medizin“ — Berlin 1966

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Dördelmann, P., Jilo, J. & Saalmüller, H. Immuntoleranz gegen Blutgruppenantigene im Tierexperiment. Arch. Gynak. 208, 72–79 (1969). https://doi.org/10.1007/BF00673480

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  • DOI: https://doi.org/10.1007/BF00673480

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