Skip to main content
Log in

Biomedical applications of complexation agents/solubilizers

  • Published:
Journal of inclusion phenomena Aims and scope Submit manuscript

Abstract

Non-toxic complexation agents/solubilizers have numerous applications in the biomedical field. Results obtained in the author's laboratory are reviewed here. This work resulted in: (a) the development of a system enabling more efficient therapeutic use of retinoids, (b) the development of an agent eliminating mycoplasma infections in cell cultures, (c) the development of a detoxification process for hypervitaminosis A, and (d) the development of a system for effective sublingual administration of sex hormones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Pitha, J., Kociolek, K., and Caron, M. G.: ‘Detergents linked to polysaccharides: preparation and effects on membranes and cells.’Eur. J. Biochem. 94, 11–18 (1979).

    Google Scholar 

  2. Pitha, J. and Szente, L.: ‘Digitonin derivatives of low toxicity: potential solubilizers for lipophilic compounds.’J. Pharm. Sci. 73, 240–243 (1984).

    Google Scholar 

  3. Pitha, J., Szente, L., and Greenberg, J.: ‘Poly-L-methionine sulfoxide: a biologically inert analogue of dimethyl sulfoxide with solubilizing potency.’J. Pharm. Sci. 72, 665–668 (1983).

    Google Scholar 

  4. Pitha, J., Zawadzki, S., Chytil, F., Lotan, D., and Lotan, R.: ‘Water-soluble, dextran-linked retinal: preparation, vitamin A-like activity in rats, and effects on melanoma cells.’J. Natl. Cancer Inst. 65, 1011–1015 (1980).

    Google Scholar 

  5. Pitha, J.: ‘Enhanced water solubility of vitamins A, D, E, and K by substituted cycloamyloses.’Life Sci. 29, 307–311 (1981).

    Google Scholar 

  6. Pitha, J. and Szente, L.: ‘Rescue from hypervitaminosis A or potentiation of retinoid toxicity by different modes of cyclodextrin administration.’Life Sci. 32, 719–723 (1983).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pitha, J. Biomedical applications of complexation agents/solubilizers. Journal of Inclusion Phenomena 2, 477–485 (1984). https://doi.org/10.1007/BF00662214

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00662214

Keywords

Navigation