Abstract
The esterolysis ofm-nitrophenyl acetate (mNPA) andp-nitrophenyl acetate (pNPA), complexed with α-cyclodextrin, was investigated in the solid state. At 117 and 140°C, the initial half-times ofmNPA esterolysis were 30 and 24 h, respectively, whereasp NPA esterolysis was undetectably slow. At 117°C, themNPA reaction proceeded to completion, and cyclodextrin acetate andm-nitrophenol products were identified. At 140°C,the initial rate was followed by a slow phase with a half-time of 130 h, evidently due to a structural change in the complex. Themeta/para selectivity of the solid-state reaction is considerably enhanced over the selectivity reported in aqueous solution.
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Wernick, D.L., Savion, Z. & Levy, J. Selective esterolysis of nitrophenyl acetates in crystalline α-cyclodextrin complexes. Journal of Inclusion Phenomena 6, 483–490 (1988). https://doi.org/10.1007/BF00660746
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DOI: https://doi.org/10.1007/BF00660746