Skip to main content
SpringerLink
Log in

Effect of acetylsalicylic acid on renal function in systemic lupus erythematosus

  • Originals
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

Glomerular filtration rate (GFR;51Cr-EDTA clearance), serum creatinine concentration and urinary excretion of prostaglandins were measured in 8 patients with systemic lupus erythematosus (SLE) before and after 2 weeks of treatment with acetylsalicylic acid (ASA). ASA 65 mg/kg or up to 4 g/daily was given as a sustained release preparation. The serum salicylate concentration ranged from 0.3 to 1.6 mmol/l. Serum creatinine after 1 and 2 weeks and GFR after 2 weeks of ASA treatment showed no significant changes. There was a clearcut decrease in urinary excretion of prostaglandins PGE2 and PGF2α, by 44% and 50%, respectively. It is concluded that therapeutic doses of ASA do not cause deterioration of GFR in patients with SLE and normal or moderately reduced renal function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kimberly RP, Plotz PH (1977) Aspirin-induced depression of renal function. N Engl J Med 296: 418–424

    Google Scholar 

  2. Burry HC, Dieppe PA (1976) Apparent reduction of endogenous creatinine clearance by salicylate treatment. Br Med J 2: 16–17

    Google Scholar 

  3. Kimberly RP, Gill JR, Bowden RE, Keiser HR, Plotz PH (1978) Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus. Ann Intern Med 89: 336–341

    Google Scholar 

  4. Kimberly RP, Bowden RE, Keiser HR, Plotz PH (1978) Reduction of renal function by newer nonsteroidal anti-inflammatory drugs. Am J Med 64: 804–807

    Google Scholar 

  5. Nielsen IL, Rasmussen S, Hilden T (1980) Acetylsalicylic acid and renal function. Br Med J 180: 610

    Google Scholar 

  6. Cohen AS, Reynolds WE, Franklin EC, Kulka JP, Ropes MW, Shulman LE, Wallace SL (1971) Preliminary criteria for the classification of systemic lupus erythematosus. Bull Rheum Dis 21: 643–648

    Google Scholar 

  7. Trinder P (1954) Rapid determination of salicylate in biological fluids. Biochem J 57: 301–303

    Google Scholar 

  8. Bosnes RW, Taussky HH (1945) On the colorimetric determination of creatinine by the Jaffe reaction. J Biol Chem 158: 581–591

    Google Scholar 

  9. Brøchner-Mortensen J (1972) A simple method for the determination of glomerular filtration rate. Scand J Clin Lab Invest 30: 271–274

    Google Scholar 

  10. Christensen P, Leyssac PP (1976) A specific radioimmunoassay for PGE2 using an antibody with high specificity and a Sephadex LH-20 microcolumn for the separation of prostaglandins. Prostaglandins 11: 399–420

    Google Scholar 

  11. Leyssac PP, Christensen P (1982) A study of the effect of stimulated endogenous prostaglandin synthesis on urine flow, osmolar excretion rate, and renin release in hydropenic and saline loaded, anaesthetized rats. Acta Physiol Scand (in press)

  12. Koch-Weser J (1972) Serum drug concentrations as therapeutic guides. N Engl J Med 287: 227–231

    Google Scholar 

  13. Beely L, Kendall MJ (1971) Effect of aspirin on renal clearance of125I-diatrizoate. Br Med J 1: 707–708

    Google Scholar 

  14. Robert M, Fillastre JP, Berger H, Malandain H (1972) Effect of intravenous infusion of acetylsalicylic acid on renal function. Br Med J 1: 466–467

    Google Scholar 

  15. Silverstein ME, Feldman RC, Henderson LW, Engelman K (1975) Acute effects of indomethacin and aspirin on human renal function. Clin Res 23: 374A

  16. Berg KJ (1977) Acute effects of acetylsalicylic acid in patients with chronic renal insufficiency. Eur J Clin Pharmacol 11: 111–116

    Google Scholar 

  17. Berg KJ (1977) Acute effects of acetylsalicylic acid on renal function in normal man. Eur J Clin Pharmacol 11: 117–123

    Google Scholar 

  18. Brooks PM, Cossum P (1978) Salicylates and creatinine clearance re-evaluated. Aust NZ J Med 8: 660–661

    Google Scholar 

  19. Macklon AF, Craft AW, Thompson M, Kerr KNS (1974) Aspirin and analgesic nephropathy. Br Med J 1: 597–600

    Google Scholar 

  20. Dunn MJ, Hood VL (1977) Prostaglandins and the kidney. Am J Physiol 233: F169-F184

    Google Scholar 

  21. McGiff JC (1980) Interactions of prostaglandins with the kallikrein-kinin and renin-angiotensin systems. Clin Sci 59: 105s-116s

    Google Scholar 

  22. Epstein M, Lifschitz MD (1980) Volume status as a determinant of the influence of renal PGE on renal function. Nephron 25: 157–159

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Department C, Diakonissestiftelsen, Medical Department TA, Rigshospitalet and the University Institute for Experimental Medicine, Copenhagen, Denmark

    S. Rasmussen, J. Petersen, I. L. Nielsen, P. Christensen & T. Hilden

  2. Department of Clinical Physiology, Glostrup Hospital, DK-2600, Glostrup, Copenhagen, Denmark

    S. Rasmussen

Authors
  1. S. Rasmussen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Petersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. L. Nielsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Christensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Hilden
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rasmussen, S., Petersen, J., Nielsen, I.L. et al. Effect of acetylsalicylic acid on renal function in systemic lupus erythematosus. Eur J Clin Pharmacol 23, 505–508 (1982). https://doi.org/10.1007/BF00637497

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00637497

Key words

Search

Navigation